Results 301 to 310 of about 1,485,305 (342)
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Cytotoxicity of furoxans: quantitative structure-activity relationships study
Il Farmaco, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Mercedes González +2 more
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Quantitative Structure Activity Relationships (QSAR)
1995The development of new effective chemical substances, such as new drugs, herbicides or insecticides, is essential for the survival of an agro-chemical and pharmaceutical industry. The process of finding biologically active compounds is very research-intensive and time consuming, illustrated by the fact that typically only about 1 of 10’000 synthesized ...
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Quantitative structure-activity relationships for skin permeability
Toxicology in Vitro, 1995In vitro human skin permeability coefficient data collected by Flynn (1990) have been analysed using multiple regression analysis. An improved model for the prediction of permeability coefficients has been derived by the inclusion of the melting point as an independent variable in addition to the octanol-water partition coefficient (as logP) and ...
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Chromatography in studies of quantitative structure-activity relationships
Journal of Chromatography A, 1981The rational bases, experimental techniques and conditions required for the chromatographic determination of the structural data of importance for studies on quantitative relationships between chemical structure and biological activity of drugs (QSAR) are reviewed. Practical applications of the information gathered from various chromatographic modes in
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Quantitative structure?activity relationships of a 1 adrenergic antagonists
Journal of Molecular Modeling, 2004A quantitative structure-activity relationship study with respect to selectivity for alpha1 adrenoreceptor subtypes (alpha1a, alpha1b and alpha1d) of a wide series of structurally heterogeneous alpha1 adrenoreceptor antagonists has been performed. A large variety of molecular descriptors have been calculated and then analyzed by a heuristic method. The
Erić, Slavica +5 more
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Reinvestigation of a nonadditive quantitative structure-activity relation
Journal of Medicinal Chemistry, 1974AbstractToxizitäten an disubstituierten Aromaten werden theoretisch diskutiert.
Arthur Cammarata, Thomas M. Bustard
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Quantitative structure - activity relationships of cardiotonic agents
2000Quantitative structure-activity relationships (QSARs) of different cardiotonic agents are presented. A critical analysis of all QSARs provides a very vivid picture of the mechanisms of varying cardiotonic agents. The cardiotonics can be broadly put into 2 categories: cardiac glycosides and nonglycoside cardiotonics, which include phosphodiesterase of ...
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ChemInform Abstract: Quantitative Structure—Activity Relationships of Antiarrhythmic Drugs
ChemInform, 1998AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Sorption and Quantitative Structure-Activity Relationship (QSAR)
2014The sorption of pesticides to soils or sediments is the major factor determining their mobility, transport and bioavailability in terrestrial and aquatic environments. The organic matter is the primary sorption domain in soils or sediments and sorption is considered to be primarily a partitioning process between soil organic matter and the surrounding ...
Aleksandar Sabljic, Yoshiaki Nakagawa
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Quantitative structure—activity relationships for nicotinanilide molluscicides
Pesticide Science, 1980AbstractStructure‐activity correlations for the toxicity of nicotinanilides to Biomphalaria glabrata have been studied in terms of partitioning, charge transfer and steric properties. Partition coefficients or πNA values (substituent constants for nicotinanilides, reflecting the influence on the partition coefficient of a substituent on the parent ...
Geoffrey Ayrey +2 more
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