Results 101 to 110 of about 3,366,415 (310)

Optimized Cas9‐Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders

Advanced Science, EarlyView.
An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee, Chanju Jung, Minjeong Kim, Narae Kim, Gue‐Ho Hwang, Soon‐Tae Lee, Kon Chu, Sang Kun Lee, Han‐Joon Kim, Jong‐Hee Chae, Sangsu Bae, Jangsup Moon   +11 more
wiley   +1 more source

Tests for the replication of an association between Egfr and natural variation in Drosophila melanogaster wing morphology

BMC Genetics, 2005
Background Quantitative differences between individuals stem from a combination of genetic and environmental factors, with the heritable variation being shaped by evolutionary forces.
Dodgson James, Palsson Arnar, Dworkin Ian, Gibson Greg   +3 more
doaj   +1 more source

Quantitative Traits: Heritability, Linkage & Association

, 2017
Talk given as part of the "Introduction to Imaging Genetics" workshop during the 2010 Organization for Human Brain Mapping (OHBM) conference in Barcelona.
openaire   +1 more source

Heritability and gene effects for yield related quantitative traits in eggplant

Annals of Agricultural Sciences, 2016
AbstractKnowledge of gene actions and their relative contribution in expression of characters is of great importance. Therefore, four crosses were made among the six parents viz., Doli-5×GBL-1 (cross 1), Doli-5×KS-331 (cross 2), Pusa Uttam×KS-331 (cross 3) and AB 07-02×GOB 1 (cross 4) to study gene actions responsible for inheritance of twelve fruit ...
Chintan Mistry, Keshubhai B. Kathiria, Srikanth Sabolu, Sushil Kumar   +3 more
openaire   +2 more sources

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

Host genetics influence the rumen microbiota and heritable rumen microbial features associate with feed efficiency in cattle

Microbiome, 2019
Background The symbiotic rumen microbiota is essential for the digestion of plant fibers and contributes to the variation of production and health traits in ruminants.
Fuyong Li, Changxi Li, Yanhong Chen, Junhong Liu, Chunyan Zhang, Barry Irving, Carolyn Fitzsimmons, Graham Plastow, Le Luo Guan   +8 more
doaj   +1 more source

Admixture mapping of quantitative trait loci for blood lipids in African-Americans [PDF]

, 2009
Blood lipid levels, including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG), are highly heritable traits and major risk factors for atherosclerotic cardiovas-cular disease (CVD).
Analabha Basu, Cora E. Lewis, T. H. Mosley, Eric Boerwinkle, J. D. Curb, Basu, A., E. Boerwinkle, N. J. Risch, Boerwinkle, E., Neil J. Risch, T. Quertermous, J. David Curb, Curb, J. D., North, K., Risch, N. J., Zhu, X., X. Zhu, A. Basu, C. E. Lewis, Lewis, C. E., Xiaofeng Zhu, H. Tang, Hua Tang, Thomas H. Mosley, Quertermous, T., Mosley, T. H., Kari North, Tang, H., K. North   +28 more
core   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Quantitative Genetic Dissection of Shoot Architecture Traits in Maize: Towards a Functional Genomics Approach

The Plant Genome, 2008
Quantitative trait loci (QTL) affecting the total number of leaves made before flowering and the number of leaves below the uppermost ear (NLBE) were mapped and characterized using the intermated B73 × Mo17 recombinant inbred lines (IBMRILs) of maize ( L.
Nick Lauter, Matthew J. Moscou, Josh Habiger, Stephen P. Moose   +3 more
doaj   +1 more source

Complex variation in measures of general intelligence and cognitive change [PDF]

, 2013
Copyright: © 2013 Tenesa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Rowe, Suzanne J, Amy Rowlatt, Harris Sarah E., John M. Starr (107707), McNeill Geraldine, Sarah E Harris, Geraldine McNeill, Porteous, David J, Ian J Deary, Suzanne J. Rowe (496302), Davies Gail, Rowlatt, Amy, Davies, Gail, Gail Davies, Starr, John M, Liewald David C., Suzanne J Rowe, Amy Rowlatt (496303), Albert Tenesa (107674), Deary, Ian J, David J Porteous, Tenesa, Albert, Gail Davies (107670), Rowe Suzanne J., Rowlatt, Amy Elizabeth, McNeill, Geraldine, Starr John M., Liewald, David C, Deary Ian J., Tenesa Albert, John M Starr, David C Liewald, Rowlatt Amy, David C. Liewald (496304), Geraldine McNeill (107695), Porteous David J., Albert Tenesa, David J. Porteous (107720), Ian J. Deary (107724), Sarah E. Harris (107676), Harris, Sarah E   +40 more
core   +1 more source