Results 111 to 120 of about 55,223 (296)

Psychiatric genetics and the structure of psychopathology [PDF]

, 2018
For over a century, psychiatric disorders have been defined by expert opinion and clinical observation. The modern DSM has relied on a consensus of experts to define categorical syndromes based on clusters of symptoms and signs, and, to some extent ...
Andreassen, Ole A., Edenberg, Howard J., Faraone, Stephen V., Glatt, Stephen J., Kendler, Kenneth S., Smoller, Jordan W.   +5 more
core   +1 more source

Quantitative Traits: Heritability, Linkage & Association

, 2017
Talk given as part of the "Introduction to Imaging Genetics" workshop during the 2010 Organization for Human Brain Mapping (OHBM) conference in Barcelona.
openaire   +1 more source

Genomic Structural Variations Provide Insights Into Litter Size and Teat Number Traits in Hu Sheep

Animal Research and One Health, EarlyView.
Here, we conducted whole genome sequencing on 300 Hu sheep with an average depth of 16.51X. Two candidate genes associated with litter size and teat number traits were identified, namely MAST2 and AFDN. ABSTRACT Litter size and the teat number are important economic indicators in sheep production.
Xin Xiang, Wei Dai, Jiqiang Liu, Zhengguang Wang   +3 more
wiley   +1 more source

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, EarlyView.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

Characterization of genome-methylome interactions in 22 nuclear pedigrees.

PLoS ONE, 2014
Genetic polymorphisms can shape the global landscape of DNA methylation, by either changing substrates for DNA methyltransferases or altering the DNA binding affinity of cis-regulatory proteins.
Nongluk Plongthongkum, Kristel R van Eijk, Simone de Jong, Tina Wang, Jae Hoon Sul, Marco P M Boks, René S Kahn, Ho-Lim Fung, Roel A Ophoff, Kun Zhang   +9 more
doaj   +1 more source

Deciphering the catalytic and pharmacological mechanisms of Coptis chinensis herbzymes to renovate intestinal microenvironment for colitis alleviation

BMEMat, EarlyView.
The synthesized CCzymes possess both antioxidant enzyme activity and pharmacological properties inherent to Coptis chinensis. By their antioxidant enzyme activity, CCzymes can attenuate oxidative stress within the inflammatory region of ulcerative colitis (UC), while their pharmacological activity acts on macrophage polarization and the intestinal ...
Zhichao Deng, Can Li, Yujie Zhang, Yuanyuan Zhu, Chenxi Xu, Bowen Gao, Mingxin Zhang, Martina H. Stenzel, Kelong Fan, Mingzhen Zhang, Yanyan Jiang   +10 more
wiley   +1 more source

Natural variation reveals that intracellular distribution of ELF3 protein is associated with function in the circadian clock

eLife, 2014
Natural selection of variants within the Arabidopsis thaliana circadian clock can be attributed to adaptation to varying environments. To define a basis for such variation, we examined clock speed in a reporter-modified Bay-0 x Shakdara recombinant ...
Muhammad Usman Anwer, Eleni Boikoglou, Eva Herrero, Marc Hallstein, Amanda Melaragno Davis, Geo Velikkakam James, Ferenc Nagy, Seth Jon Davis   +7 more
doaj   +1 more source

Using Extended Genealogy to Estimate Components of Heritability for 23 Quantitative and Dichotomous Traits

PLoS Genetics, 2013
Important knowledge about the determinants of complex human phenotypes can be obtained from the estimation of heritability, the fraction of phenotypic variation in a population that is determined by genetic factors. Here, we make use of extensive phenotype data in Iceland, long-range phased genotypes, and a population-wide genealogical database to ...
Zaitlen, Noah, Patterson, Nick, Pasaniuc, Bogdan, Price, Alkes L., Kraft, Phillip, Bhatia, Gaurav, Pollack, Samuela   +6 more
openaire   +6 more sources

Individualised niches: an integrative conceptual framework across behaviour, ecology, and evolution

Biological Reviews, EarlyView.
ABSTRACT Individuals differ. While seemingly trivial, this insight has nevertheless led to paradigm shifts, as three key fields of organismal biology have seen marked changes in key concepts over the past few decades. In animal behaviour, it has become increasingly recognised that behavioural differences among individuals can be stable over time and ...
Oliver Krüger, Jaime Anaya‐Rojas, Mitja Back, Barbara Caspers, Nayden Chakarov, Melanie Dammhahn, Alkistis Elliott‐Graves, Claudia Fricke, Jürgen Gadau, Joseph I. Hoffman, Marie I. Kaiser, Sylvia Kaiser, Peter Korsten, Ulrich Krohs, Joachim Kurtz, Roland Langrock, Caroline Müller, Robert Peuß, Klaus Reinhold, Helene Richter, Norbert Sachser, Holger Schielzeth, Tim Schmoll, Ralf Stanewsky, Tamas Szekely, Franz J. Weissing, Meike Wittmann, Shuqing Xu   +27 more
wiley   +1 more source

Heritability and genetic loci of fatty liver in familial combined hyperlipidemia

Journal of Lipid Research, 2006
VLDL overproduction, a process that is driven by an excess amount of hepatic fat, is a well-documented feature of familial combined hyperlipidemia (FCHL).
Martijn C. G.J. Brouwers, Rita M. Cantor, Naoko Kono, Jeong lim Yoon, Carla J.H. van der Kallen, Monique A.L. Bilderbeek-Beckers, Marleen M.J. van Greevenbroek, Aldons J. Lusis, Tjerk W.A. de Bruin   +8 more
doaj   +1 more source