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More Than Regulation: Challenging Habermas on the Future of the Public Sphere
Journal of Social Philosophy, EarlyView.
Bernardo Ferro
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Nature Genetics, 2021
Genome-wide association studies have identified thousands of noncoding variants associated with human traits and diseases. However, the functional interpretation of these variants is a major challenge. Here, we constructed a multi-tissue atlas of human 3'UTR alternative polyadenylation (APA) quantitative trait loci (3'aQTLs), containing approximately 0.
Lei Li +12 more
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Genome-wide association studies have identified thousands of noncoding variants associated with human traits and diseases. However, the functional interpretation of these variants is a major challenge. Here, we constructed a multi-tissue atlas of human 3'UTR alternative polyadenylation (APA) quantitative trait loci (3'aQTLs), containing approximately 0.
Lei Li +12 more
openaire +2 more sources
Regulatory variation in hepcidin expression as a heritable quantitative trait
Biochemical and Biophysical Research Communications, 2009Genetic variation underlies phenotypic diversity and complex quantitative traits including heritable diseases. We hypothesized that such variation may underlie or determine intrinsic inter-individual differences in iron metabolism and may also play a role in variable phenotypes associated with iron-related diseases.
Henry K, Bayele, Surjit K S, Srai
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Heritability estimation of sex‐specific effects on human quantitative traits
Genetic Epidemiology, 2007AbstractRecent studies have suggested that sex‐specific genetic architecture could be because of the effects of autosomal genes that are differentially expressed in males and females. Yet, few studies have explored the effects of X‐linked genes on sex‐specific genetic architecture.
Lin, Pan, Carole, Ober, Mark, Abney
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IS SURVIVAL TIME AFTER HEMORRHAGE A HERITABLE, QUANTITATIVE TRAIT?
Shock, 2008Enhancing survival to hemorrhage of both civilian and military patients is a major emphasis for trauma research. Previous observations in humans and outbred rats show differential survival to similar levels of hemorrhage. In an initial attempt to determine potential genetic components of such differential outcomes, survival time after a controlled ...
Harold G, Klemcke +7 more
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Statistical power and heritability in whole-genome association studies for quantitative traits
Meta Gene, 2021Abstract The genome-wide association studies (GWAS) have made many advances in identifying the underlying genetics of diseases and quantitative traits. Still, GWAS has major problems, such as the lack of justification for genetic variation and the inability to fully recognize the rare variants. Probably the next generation sequencing (NGS) technology
Hassan Khanzadeh +2 more
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Principal Components of Heritability for High Dimension Quantitative Traits and General Pedigrees
Statistical Applications in Genetics and Molecular Biology, 2012For many complex disorders, genetically relevant disease definition is still unclear. For this reason, researchers tend to collect large numbers of items related directly or indirectly to the disease diagnostic. Since the measured traits may not be all influenced by genetic factors, researchers are faced with the problem of choosing which traits or ...
Oualkacha, Karim +4 more
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Heritability of quantitative orbital traits.
Human biology, 1990We conducted a study of 63 couples and their 242 normal children from northeastern Brazil (no facial malformations or deformities) to evaluate the heritability of 4 quantitative traits of the orbital region adjusted by covariance for sex, age, (age)2, sex x age, and sex x (age)2.
C M, Raposo-do-Amaral +3 more
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Quantitative genetics of cranial nonmetric traits in randombred mice: Heritability and etiology
American Journal of Physical Anthropology, 1986AbstractCheverud and Buikstra (1981) demonstrated a tendency for nonmetric traits representing the number of foramina to have lower heritabilities than those representing hyperstotic or hypostotic traits in a sample of rhesus macaques. Based on this observation, Cheverud and Buikstra hypothesize that differences in the heritability of the two sets of ...
J T, Richtsmeier, J W, McGrath
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