Automated quantitative trait locus analysis (AutoQTL) [PDF]
BioData Mining, 2023 Background Quantitative Trait Locus (QTL) analysis and Genome-Wide Association Studies (GWAS) have the power to identify variants that capture significant levels of phenotypic variance in complex traits.
Philip J. Freda +19 more
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A molecular quantitative trait locus map for osteoarthritis [PDF]
Nature Communications, 2021 Understanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthritis ...
Julia Steinberg +14 more
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Complex genetic interactions in a quantitative trait locus. [PDF]
PLoS Genetics, 2006 Whether in natural populations or between two unrelated members of a species, most phenotypic variation is quantitative. To analyze such quantitative traits, one must first map the underlying quantitative trait loci.
Himanshu Sinha +3 more
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Combined expression trait correlations and expression quantitative trait locus mapping. [PDF]
PLoS Genetics, 2006 Coordinated regulation of gene expression levels across a series of experimental conditions provides valuable information about the functions of correlated transcripts.
Hong Lan +12 more
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Mapping of a Quantitative Trait Locus for Stay-Green Trait in Common Wheat [PDF]
PlantsThe stay-green (SG) trait enhances photosynthetic activity during the late grain-filling period, benefiting grain yield under drought and heat stresses. CH7034 is a wheat breeding line with SG.
Xin Li +10 more
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Multiple-trait quantitative trait locus mapping with incomplete phenotypic data [PDF]
BMC Genetics, 2008 Background Conventional multiple-trait quantitative trait locus (QTL) mapping methods must discard cases (individuals) with incomplete phenotypic data, thereby sacrificing other phenotypic and genotypic information contained in the discarded cases. Under
Guo Zhigang, Nelson James C
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Covariance between relatives for a marked quantitative trait locus [PDF]
Genetics Selection Evolution, 1995 Summary - Best linear unbiased prediction (BLUP) can be applied to marker-assisted selection. This application requires computation of the inverse of the conditional covariance matrix (Gof additive effects for the quantitative trait locus (QTL) linked to the marker locus (ML), given marker genotypes.
van Arendonk JAM +4 more
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Expression quantitative trait locus studies in the era of single-cell omics [PDF]
Frontiers in Genetics, 2023 Genome-wide association studies have revealed that the regulation of gene expression bridges genetic variants and complex phenotypes. Profiling of the bulk transcriptome coupled with linkage analysis (expression quantitative trait locus (eQTL) mapping ...
Jie Luo +5 more
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A Quantitative Trait Locus Influencing Anxiety in the Laboratory Rat [PDF]
Genome Research, 2002 A critical test for a gene that influences susceptibility to fear in animals is that it should have a consistent pattern of effects across a broad range of conditioned and unconditioned models of anxiety. Despite many years of research, definitive evidence that genetic effects operate in this way is lacking.
Fernández-Teruel, A +12 more
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Dissecting the Genetic Basis of Yield Traits and Validation of a Novel Quantitative Trait Locus for Grain Width and Weight in Rice [PDF]
PlantsGrain yield in rice is a complex trait and it is controlled by a number of quantitative trait loci (QTL). To dissect the genetic basis of rice yield, QTL analysis for nine yield traits was performed using an F2 population containing 190 plants, which was
Man Yin +7 more
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