Results 1 to 10 of about 185,736 (294)

Automated quantitative trait locus analysis (AutoQTL) [PDF]

BioData Mining, 2023
Background Quantitative Trait Locus (QTL) analysis and Genome-Wide Association Studies (GWAS) have the power to identify variants that capture significant levels of phenotypic variance in complex traits.
Philip J. Freda, Attri Ghosh, Elizabeth Zhang, Tianhao Luo, Apurva S. Chitre, Oksana Polesskaya, Celine L. St. Pierre, Jianjun Gao, Connor D. Martin, Hao Chen, Angel G. Garcia-Martinez, Tengfei Wang, Wenyan Han, Keita Ishiwari, Paul Meyer, Alexander Lamparelli, Christopher P. King, Abraham A. Palmer, Ruowang Li, Jason H. Moore   +19 more
doaj   +7 more sources

Combined expression trait correlations and expression quantitative trait locus mapping. [PDF]

PLoS Genetics, 2006
Coordinated regulation of gene expression levels across a series of experimental conditions provides valuable information about the functions of correlated transcripts.
Hong Lan, Meng Chen, Jessica B Flowers, Brian S Yandell, Donnie S Stapleton, Christine M Mata, Eric Ton-Keen Mui, Matthew T Flowers, Kathryn L Schueler, Kenneth F Manly, Robert W Williams, Christina Kendziorski, Alan D Attie   +12 more
doaj   +6 more sources

SUP: an extension to SLINK to allow a larger number of marker loci to be simulated in pedigrees conditional on trait values [PDF]

BMC Genetics, 2006
Background With the recent advances in high-throughput genotyping technologies that allow for large-scale association mapping of human complex traits, promising statistical designs and methods have been emerging.
Lemire Mathieu
doaj   +3 more sources

Multiple-trait quantitative trait locus mapping with incomplete phenotypic data [PDF]

BMC Genetics, 2008
Background Conventional multiple-trait quantitative trait locus (QTL) mapping methods must discard cases (individuals) with incomplete phenotypic data, thereby sacrificing other phenotypic and genotypic information contained in the discarded cases. Under
Guo Zhigang, Nelson James C
doaj   +3 more sources

A molecular quantitative trait locus map for osteoarthritis [PDF]

Nature Communications, 2021
Understanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthritis ...
Julia Steinberg, Lorraine Southam, Theodoros I. Roumeliotis, Matthew J. Clark, Raveen L. Jayasuriya, Diane Swift, Karan M. Shah, Natalie C. Butterfield, Roger A. Brooks, Andrew W. McCaskie, J. H. Duncan Bassett, Graham R. Williams, Jyoti S. Choudhary, J. Mark Wilkinson, Eleftheria Zeggini   +14 more
doaj   +8 more sources

Complex genetic interactions in a quantitative trait locus. [PDF]

PLoS Genetics, 2006
Whether in natural populations or between two unrelated members of a species, most phenotypic variation is quantitative. To analyze such quantitative traits, one must first map the underlying quantitative trait loci.
Himanshu Sinha, Bradly P Nicholson, Lars M Steinmetz, John H McCusker   +3 more
doaj   +5 more sources

Mapping of a Quantitative Trait Locus for Stay-Green Trait in Common Wheat [PDF]

Plants
The stay-green (SG) trait enhances photosynthetic activity during the late grain-filling period, benefiting grain yield under drought and heat stresses. CH7034 is a wheat breeding line with SG.
Xin Li, Xin Bai, Lijuan Wu, Congya Wang, Xinghui Liu, Qiqi Li, Xiaojun Zhang, Fang Chen, Chengda Lu, Wei Gao, Tianling Cheng   +10 more
doaj   +2 more sources

A quantitative trait locus analysis of personality in wild bighorn sheep [PDF]

Ecology and Evolution, 2013
Personality, the presence of persistent behav105 ioral differences among individuals over time or contexts, potentially has important ecological and evolutionary consequences. However, a lack of knowledge about its genetic architecture limits our ability
J. Poissant, D. Réale, J.G.A. Martin, M. Festa‐Bianchet, D.W. Coltman   +4 more
doaj   +3 more sources

A hierarchical Bayesian approach to multi-trait clinical quantitative trait locus modeling [PDF]

Frontiers in Genetics, 2012
Recent advances in high-throughput genotyping and transcript profiling technologies have enabled the inexpensive production of genome-wide dense marker maps in tandem with huge amounts of expression profiles.
Crispin M. Mutshinda, Nelly eNoykova, Mikko J. Sillanpää, Mikko J. Sillanpää   +3 more
doaj   +3 more sources

Cell Specific eQTL Analysis without Sorting Cells. [PDF]

PLoS Genetics, 2015
The functional consequences of trait associated SNPs are often investigated using expression quantitative trait locus (eQTL) mapping. While trait-associated variants may operate in a cell-type specific manner, eQTL datasets for such cell-types may not ...
Harm-Jan Westra, Danny Arends, Tõnu Esko, Marjolein J Peters, Claudia Schurmann, Katharina Schramm, Johannes Kettunen, Hanieh Yaghootkar, Benjamin P Fairfax, Anand Kumar Andiappan, Yang Li, Jingyuan Fu, Juha Karjalainen, Mathieu Platteel, Marijn Visschedijk, Rinse K Weersma, Silva Kasela, Lili Milani, Liina Tserel, Pärt Peterson, Eva Reinmaa, Albert Hofman, André G Uitterlinden, Fernando Rivadeneira, Georg Homuth, Astrid Petersmann, Roberto Lorbeer, Holger Prokisch, Thomas Meitinger, Christian Herder, Michael Roden, Harald Grallert, Samuli Ripatti, Markus Perola, Andrew R Wood, David Melzer, Luigi Ferrucci, Andrew B Singleton, Dena G Hernandez, Julian C Knight, Rossella Melchiotti, Bernett Lee, Michael Poidinger, Francesca Zolezzi, Anis Larbi, De Yun Wang, Leonard H van den Berg, Jan H Veldink, Olaf Rotzschke, Seiko Makino, Veikko Salomaa, Konstantin Strauch, Uwe Völker, Joyce B J van Meurs, Andres Metspalu, Cisca Wijmenga, Ritsert C Jansen, Lude Franke   +57 more
doaj   +4 more sources