A molecular quantitative trait locus map for osteoarthritis [PDF]
Nature Communications, 2021 Understanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthritis ...
Julia Steinberg +14 more
doaj +3 more sources
Optimizing expression quantitative trait locus mapping workflows for single-cell studies [PDF]
Genome Biology, 2021 Background Single-cell RNA sequencing (scRNA-seq) has enabled the unbiased, high-throughput quantification of gene expression specific to cell types and states.
Anna S. E. Cuomo +5 more
doaj +3 more sources
Automated quantitative trait locus analysis (AutoQTL) [PDF]
BioData Mining, 2023 Background Quantitative Trait Locus (QTL) analysis and Genome-Wide Association Studies (GWAS) have the power to identify variants that capture significant levels of phenotypic variance in complex traits.
Philip J. Freda +19 more
doaj +2 more sources
Mapping of a Quantitative Trait Locus for Stay-Green Trait in Common Wheat [PDF]
PlantsThe stay-green (SG) trait enhances photosynthetic activity during the late grain-filling period, benefiting grain yield under drought and heat stresses. CH7034 is a wheat breeding line with SG.
Xin Li +10 more
doaj +2 more sources
A quantitative trait locus analysis of personality in wild bighorn sheep [PDF]
Ecology and Evolution, 2013 Personality, the presence of persistent behav105 ioral differences among individuals over time or contexts, potentially has important ecological and evolutionary consequences. However, a lack of knowledge about its genetic architecture limits our ability
J. Poissant +4 more
doaj +3 more sources
Expression quantitative trait locus studies in the era of single-cell omics [PDF]
Frontiers in Genetics, 2023 Genome-wide association studies have revealed that the regulation of gene expression bridges genetic variants and complex phenotypes. Profiling of the bulk transcriptome coupled with linkage analysis (expression quantitative trait locus (eQTL) mapping ...
Jie Luo +5 more
doaj +2 more sources
Cell Specific eQTL Analysis without Sorting Cells. [PDF]
PLoS Genetics, 2015 The functional consequences of trait associated SNPs are often investigated using expression quantitative trait locus (eQTL) mapping. While trait-associated variants may operate in a cell-type specific manner, eQTL datasets for such cell-types may not ...
Harm-Jan Westra +57 more
doaj +4 more sources
Expression quantitative trait locus mapping of extracellular microRNAs in human plasma [PDF]
iScienceSummary: MicroRNAs, crucial in regulating protein-coding gene expression, are implicated in various diseases. We performed a genome-wide association study of plasma miRNAs (ex-miRNAs) in 3,743 Framingham Heart Study (FHS) participants and identified 1 ...
Tianxiao Huan +13 more
doaj +2 more sources
Dissecting the Genetic Basis of Yield Traits and Validation of a Novel Quantitative Trait Locus for Grain Width and Weight in Rice [PDF]
PlantsGrain yield in rice is a complex trait and it is controlled by a number of quantitative trait loci (QTL). To dissect the genetic basis of rice yield, QTL analysis for nine yield traits was performed using an F2 population containing 190 plants, which was
Man Yin +7 more
doaj +2 more sources
Combined expression trait correlations and expression quantitative trait locus mapping. [PDF]
PLoS Genetics, 2006 Coordinated regulation of gene expression levels across a series of experimental conditions provides valuable information about the functions of correlated transcripts.
Hong Lan +12 more
doaj +2 more sources