Results 91 to 100 of about 294,293 (342)

Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications

Advanced Healthcare Materials, EarlyView.
This review discusses the bioconjugation of novel materials grouped under “biological”, “hybrid” and “synthetic” categories. Medical applications ranging from cancer therapy and diagnostics to optogenetics and tissue engineering are explored, and conjugation trends are highlighted as a general guide. The review concludes with a comparison of techniques
Ellie Martin, Sean P. Doidge, Eiman Aleem, Suela Kellici, Steven Dunn, Claire Atkinson, Philip D. Howes   +6 more
wiley   +1 more source

Fast empirical Bayesian LASSO for multiple quantitative trait locus mapping

BMC Bioinformatics, 2011
Background The Bayesian shrinkage technique has been applied to multiple quantitative trait loci (QTLs) mapping to estimate the genetic effects of QTLs on quantitative traits from a very large set of possible effects including the main and epistatic ...
Xu Shizhong, Huang Anhui, Cai Xiaodong
doaj   +1 more source

A Human Neural Tube Model Using 4D Self‐Folding Smart Scaffolds

Advanced Healthcare Materials, EarlyView.
Induced pluripotent stem cells (iPSCs) exhibit features comparable to the inner cell mass of the human embryo. iPSCs are applied to a novel self‐folding 4D‐Neural Tube (4D‐NT) structure that mimics the neurulation process. This 4D‐NT model recapitulates early events of human neural development and represents a platform to explore neurodevelopmental ...
Claudia Dell'Amico, Irene Chiesa, Angela Toffano, Alessio Esposito, Piera Mancini, Chiara Magliaro, Angeliki Louvi, Carmelo De Maria, Marco Onorati   +8 more
wiley   +1 more source

Novel Resampling Improves Statistical Power for Multiple-Trait QTL Mapping

G3: Genes, Genomes, Genetics, 2017
Multiple-trait analysis typically employs models that associate a quantitative trait locus (QTL) with all of the traits. As a result, statistical power for QTL detection may not be optimal if the QTL contributes to the phenotypic variation in only a ...
Riyan Cheng, R. W. Doerge, Justin Borevitz   +2 more
doaj   +1 more source

Semiparametric Quantitative-Trait-Locus Mapping: II. on Censored Age-at-Onset [PDF]

, 2004
In genetic studies, the variation in genotypes may not only affect different inheritance patterns in qualitative traits, but may also affect the age-at-onset as quantitative trait.
Chen, Ying Qing, Hu, Chengcheng, Wu, Rongling   +2 more
core   +1 more source

Foraging environment determines the genetic architecture and evolutionary potential of trophic morphology in cichlid fishes [PDF]

, 2016
Phenotypic plasticity allows organisms to change their phenotype in response to shifts in the environment. While a central topic in current discussions of evolutionary potential, a comprehensive understanding of the genetic underpinnings of plasticity is
Albertson, R. Craig, Campbell, Calum, Concannon, Moira, Ea, Ilene, Groveas, Kiran, Navon, Dina, Parsons, Kevin J., Wang, Jason   +7 more
core   +2 more sources

Seeing inside the Body Using Wearable Sensing and Imaging Technologies

Advanced Healthcare Materials, EarlyView.
This review explores wearable technologies for noninvasive internal health monitoring. It categorizes approaches into indirect sensing (e.g., bioelectrical and biochemical signals) and direct imaging (e.g., wearable ultrasound and EIT), highlighting multimodal integration and system‐level innovation toward personalized, continuous healthcare.
Sumin Kim, Seunghun Han, Sehwan Park, Jahyun Koo   +3 more
wiley   +1 more source

Placental expression quantitative trait loci in an East Asian population

HGG Advances
Summary: Expression quantitative trait loci (eQTL) analysis measures the contribution of genetic variation in gene expression on complex traits. Although this methodology has been used to examine gene regulation in numerous human tissues, eQTL research ...
Jaeyong Choi, Seung Mi Lee, Errol R. Norwitz, Ji Hoi Kim, Young Mi Jung, Chan-Wook Park, Jong Kwan Jun, Dakyung Lee, Yongjoon Jin, Sookyung Kim, Bukyoung Cha, Joong Shin Park, Jong-Il Kim   +12 more
doaj   +1 more source

The statistical mechanics of a polygenic characterunder stabilizing selection, mutation and drift

, 2010
By exploiting an analogy between population genetics and statistical mechanics, we study the evolution of a polygenic trait under stabilizing selection, mutation, and genetic drift.
Abramowitz M., Barton N. H., Bulmer M. G., Bürger R., Crow J. F., Ewens W. J., Falconer D. S., Gavrilets S., Harold P. de Vladar, Kimura M., Kondrashov A. S., Lynch M., Lynch M., Nick H. Barton, Rattray M., Turelli M., Turelli M., Wright S., Wright S.   +18 more
core   +2 more sources

Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3 [PDF]

, 2017
Background: We have previously confirmed the importance of rat chromosome 3 (RNO3) genetic loci on blood pressure elevation, pulse pressure (PP) variability and renal pathology during salt challenge in the stroke-prone spontaneously hypertensive (SHRSP ...
Beattie, Wendy, Dashti, Mohammed, Dominiczak, Anna F., Graham, Delyth, Koh-Tan, H.H. Caline, McBride, Martin W., Mcclure, John, Wang, Ting, Young, Barbara   +8 more
core   +2 more sources