Results 91 to 100 of about 185,736 (294)

Dissecting genetic architecture of grape proanthocyanidin composition through quantitative trait locus mapping [PDF]

, 2012
Background Proanthocyanidins (PAs), or condensed tannins, are flavonoid polymers, widespread throughout the plant kingdom, which provide protection against herbivores while conferring organoleptic and nutritive values to plant-derived foods, such as wine.
Huang Yung-Fen, Doligez Agnès, Fournier-Level Alexandre, Le Cunff Loïc, Bertrand Yves, Canaguier Aurélie, Morel Cécile, Miralles Valérie, Veran Frédéric, Souquet Jean-Marc, Cheynier Véronique, Terrier Nancy, This Patrice   +12 more
core   +4 more sources

Sequential Quantitative Trait Locus Mapping in Experimental Crosses

Statistical Applications in Genetics and Molecular Biology, 2007
The etiology of complex diseases is heterogeneous. The presence of risk alleles in one or more genetic loci affects the function of a variety of intermediate biological pathways, resulting in the overt expression of disease. Hence, there is an increasing focus on identifying the genetic basis of disease by systematically studying phenotypic traits ...
Satagopan, J M, Sen, S, Churchill, G A
openaire   +3 more sources

Thermal Plasticity is Regulated by a Key MicroRNA During Range Expansion of an Invasive Fruit Fly

Advanced Science, EarlyView.
Populations at the invasion front of Bactrocera dorsalis adapt through reduced phenotypic and gene expression plasticity, a phenomenon likely to be driven by genetic assimilation. We identify a key miRNA‐mediated regulatory axis, in which miR‐276b post‐transcriptionally represses thw, a conserved chitin‐binding gene critical to the cold‐tolerance ...
Yan Zhao, Juntao Hu, Juan Du, Shaokun Guo, Youming Hou, Zhihong Li   +5 more
wiley   +1 more source

Expression quantitative trait locus analysis for translational medicine

Genome Medicine, 2015
AbstractExpression quantitative trait locus analysis has emerged as an important component of efforts to understand how genetic polymorphisms influence disease risk and is poised to make contributions to translational medicine. Here we review how expression quantitative trait locus analysis is aiding the identification of which gene(s) within regions ...
Gibson, Greg, Powell, Joseph E., Marigorta, Urko M.   +2 more
openaire   +3 more sources

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source

Gene by environment QTL mapping through multiple trait analyses in blood pressure salt-sensitivity: identification of a novel QTL in rat chromosome 5

BMC Medical Genetics, 2006
Background The genetic mechanisms underlying interindividual blood pressure variation reflect the complex interplay of both genetic and environmental variables.
Tôrres César H, Pereira Alexandre C, Soler Júlia, Krieger José E   +3 more
doaj   +1 more source

A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells

Advanced Science, EarlyView.
An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet, Sara Pugliese, Jordi Bruna, Daniel Ruiz‐Molina, Salvio Suárez‐García, Victor J. Yuste   +5 more
wiley   +1 more source

Evolution of assortative mating in a population expressing dominance.

PLoS ONE, 2011
In this article, we study the influence of dominance on the evolution of assortative mating. We perform a population-genetic analysis of a two-locus two-allele model.
Kristan A Schneider, Stephan Peischl
doaj   +1 more source

Effects of the number of markers per haplotype and clustering of haplotypes on the accuracy of QTL mapping and prediction of genomic breeding values [PDF]

, 2009
The aim of this paper was to compare the effect of haplotype definition on the precision of QTL-mapping and on the accuracy of predicted genomic breeding values.
Mario PL Calus, Theo HE Meuwissen, Jack J Windig, Egbert F Knol, Chris Schrooten, Addie LJ Vereijken, Roel F Veerkamp, THE Meuwissen, THE Meuwissen, MPL Calus, L Grapes, L Grapes, K Yu, HG deVries, D Habier, WM Muir, TR Solberg, M Lynch, T Druet, B Hayes, DS Falconer, A Legarra, RL Fernando, THE Meuwissen, WG Hill, BJ Hayes, EJ Pollak, L Ronnegard, E Uleberg   +28 more
core   +3 more sources

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source