Results 81 to 90 of about 3,713,588 (257)

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Fast empirical Bayesian LASSO for multiple quantitative trait locus mapping

BMC Bioinformatics, 2011
Background The Bayesian shrinkage technique has been applied to multiple quantitative trait loci (QTLs) mapping to estimate the genetic effects of QTLs on quantitative traits from a very large set of possible effects including the main and epistatic ...
Xu Shizhong, Huang Anhui, Cai Xiaodong
doaj   +1 more source

Genetic variation and quantitative trait loci associated with developmental stability and the environmental correlation between traits in maize [PDF]

, 2008
There is limited experimental information about the genetic basis of micro-environmental variance (V-E) (developmental stability) and environmental correlations.
Hill, William G., Malvar Pintos, Rosa Ana, Ordas, Bernardo, Ordás López, Bernardo, Malvar, Rosa A.   +4 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Quantitative Trait Locus and Genetical Genomics Analysis Identifies Putatively Causal Genes for Fecundity and Brooding in the Chicken

G3: Genes, Genomes, Genetics, 2016
Life history traits such as fecundity are important to evolution because they make up components of lifetime fitness. Due to their polygenic architectures, such traits are difficult to investigate with genetic mapping.
Martin Johnsson, Kenneth B. Jonsson, Leif Andersson, Per Jensen, Dominic Wright   +4 more
doaj   +1 more source

A multi‐trait multi‐locus stepwise approach for conducting GWAS on correlated traits

The Plant Genome, 2022
The ability to accurately quantify the simultaneous effect of multiple genomic loci on multiple traits is now possible due to current and emerging high‐throughput genotyping and phenotyping technologies.
Samuel B. Fernandes, Terry M. Casstevens, Peter J. Bradbury, Alexander E. Lipka   +3 more
doaj   +1 more source

The quantitative genetic basis of sex ratio variation in Nasonia vitripennis : a QTL study [PDF]

, 2010
Our understanding of how natural selection should shape sex allocation is perhaps more developed than for any other trait. However, this understanding is not matched by our knowledge of the genetic basis of sex allocation.
Shuker, DM, West, SA, West, S. A., Knott, SA, Pannebakker, B.A., West, S.A., R. WATT, Watt, R, D. M. SHUKER, Shuker, D. M., S. A. KNOTT, Knott, S. A., Watt, R., Shuker, D.M., B. A. PANNEBAKKER, Pannebakker, B. A., Pannebakker, BA, Knott, S.A., S. A. WEST, Shuker, David Michael, Pannebakker, Bart   +20 more
core   +2 more sources

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Future trends in Animal Breeding due to new genetic tecnologies [PDF]

, 2011
The Darwin theory of evolution by natural selection is based on three principles: (a) variation; (b) inheritance; and (c) natural selection. Here, I take these principles as an excuse to review some topics related to the future research prospects in ...
Toro Ibañez, Miguel Angel
core   +1 more source