Results 91 to 100 of about 3,713,588 (257)

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Expression quantitative trait locus analysis for translational medicine [PDF]

, 2015
Expression quantitative trait locus analysis has emerged as an important component of efforts to understand how genetic polymorphisms influence disease risk and is poised to make contributions to translational medicine.
Joseph E Powell, Gibson, Greg, Greg Gibson, Marigorta, Urko M., Urko M Marigorta, Powell, Joseph E.   +5 more
core   +1 more source

Herbicide Metabolic Resistance in Poaceae Plants via the GA‐GID1/DELLA‐DOF2‐P450s Module

Advanced Science, EarlyView.
Plant hormone signaling modulates herbicide resistance in Echinochloa crus‐galli. The GA–DELLA–DOF2 cascade directly activates P450 detoxification genes in two Poaceae species, uncovering a core mechanism of metabolic herbicide resistance. ABSTRACT Barnyard grass (Echinochloa crus‐galli) is one of the world's most important weeds, and the evolution of ...
Junzhi Wang, Jiale Qi, Lin Wei, Qin Yu, Zhongyuan Liu, Lianyang Bai, Lang Pan   +6 more
wiley   +1 more source

Strategies to assess structural variation in the chicken genome and its associations with biodiversity and biological performance [PDF]

, 2006
A primary goal in the assessment of structural variation in the avian genome is to understand the relationship of this variation with biodiversity and with biological performance. To develop such knowledge, certain essential tools are needed.
Soller, M, Lamont, S J, Weigend, S, Romanov, Michael N, Dekkers, J C M   +4 more
core   +1 more source

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

Novel Resampling Improves Statistical Power for Multiple-Trait QTL Mapping

G3: Genes, Genomes, Genetics, 2017
Multiple-trait analysis typically employs models that associate a quantitative trait locus (QTL) with all of the traits. As a result, statistical power for QTL detection may not be optimal if the QTL contributes to the phenotypic variation in only a ...
Riyan Cheng, R. W. Doerge, Justin Borevitz   +2 more
doaj   +1 more source

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

Advanced Science, EarlyView.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng, Mingmei Li, Jianjun Jiang, Yongchao Wang, Yaru Jia, Weilun Sun, Yi Yao, Pengli Gao, Linhua Zhang, Qi Guo, Guang Jia, Xing‐Jie Liang, Dunwan Zhu, Jinchao Zhang, Fangzhou Li   +14 more
wiley   +1 more source

Placental expression quantitative trait loci in an East Asian population

HGG Advances
Summary: Expression quantitative trait loci (eQTL) analysis measures the contribution of genetic variation in gene expression on complex traits. Although this methodology has been used to examine gene regulation in numerous human tissues, eQTL research ...
Jaeyong Choi, Seung Mi Lee, Errol R. Norwitz, Ji Hoi Kim, Young Mi Jung, Chan-Wook Park, Jong Kwan Jun, Dakyung Lee, Yongjoon Jin, Sookyung Kim, Bukyoung Cha, Joong Shin Park, Jong-Il Kim   +12 more
doaj   +1 more source

Gene by environment QTL mapping through multiple trait analyses in blood pressure salt-sensitivity: identification of a novel QTL in rat chromosome 5

BMC Medical Genetics, 2006
Background The genetic mechanisms underlying interindividual blood pressure variation reflect the complex interplay of both genetic and environmental variables.
Tôrres César H, Pereira Alexandre C, Soler Júlia, Krieger José E   +3 more
doaj   +1 more source

Expression quantitative trait loci are highly sensitive to cellular differentiation state [PDF]

, 2009
Blood cell development from multipotent hematopoietic stem cells to specialized blood cells is accompanied by drastic changes in gene expression for which the triggers remain mostly unknown.
Gerrits, Alice,, Xusheng Wang, Wang, Xusheng,, Breitling, Rainer, Breitling, R., Breitling, Rainer,, Gerald de Haan, Leonid V. Bystrykh, Li, Y., Dontje, B., Dontje, Bert,, Tesson, Bruno M.,, Weersing, Ellen,, Haan, Gerald de,, Bystrykh, L.V., Wang, Xusheng, Ellen Weersing, Ausema, Albertina, De Haan, Gerald, Alice Gerrits, Bert Dontje, de Haan, G., Li, Yang,, Wang, X., Gerrits, A., Bruno M Tesson, Leonid V Bystrykh, Bystrykh, Leonid V.,, Jansen, Ritsert C.,, Gerrits, Alice, Bruno M. Tesson, Jansen, Ritsert C., Rainer Breitling, Dethmers-Ausema, B, Ritsert C Jansen, Ausema, Albertina,, Albertina Ausema, Jansen, R.C., Dontje, Bert, Yang Li, Ritsert C. Jansen, Tesson, B.M., Bystrykh, Leonid V., Weersing, Ellen, de Haan, Gerald; id_orcid, Li, Yang, Tesson, Bruno M.   +46 more
core   +3 more sources