Results 91 to 100 of about 187,052 (295)
Additive Genetic Variation under Intraspecific Competition and Stabilizing Selection: A Two-Locus Study [Revised June 2002] [PDF]
, 2002 A diallelic two-locus model is investigated in which the loci determine the genotypic value of a quantitative trait additively. Fitness has two components: stabilizing selection on the trait and a frequency-dependent component, as induced for instance if
Buerger, R.
core
Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila
Advanced Science, EarlyView.Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu +7 more
wiley +1 more source
Fast empirical Bayesian LASSO for multiple quantitative trait locus mapping
BMC Bioinformatics, 2011 Background The Bayesian shrinkage technique has been applied to multiple quantitative trait loci (QTLs) mapping to estimate the genetic effects of QTLs on quantitative traits from a very large set of possible effects including the main and epistatic ...
Xu Shizhong, Huang Anhui, Cai Xiaodong
doaj +1 more source
A multi‐trait multi‐locus stepwise approach for conducting GWAS on correlated traits
The Plant Genome, 2022 The ability to accurately quantify the simultaneous effect of multiple genomic loci on multiple traits is now possible due to current and emerging high‐throughput genotyping and phenotyping technologies.
Samuel B. Fernandes +3 more
doaj +1 more source
forqs: Forward-in-time Simulation of Recombination, Quantitative Traits, and Selection [PDF]
, 2013 forqs is a forward-in-time simulation of recombination, quantitative traits, and selection. It was designed to investigate haplotype patterns resulting from scenarios where substantial evolutionary change has taken place in a small number of generations ...
Kessner, Darren, Novembre, John
core
Genetics of Intraspecies Variation in Avoidance Behavior Induced by a Thermal Stimulus in Caenorhabditis elegans. [PDF]
, 2015 Individuals within a species vary in their responses to a wide range of stimuli, partly as a result of differences in their genetic makeup. Relatively little is known about the genetic and neuronal mechanisms contributing to diversity of behavior in ...
Andolfatto, Peter +6 more
core +1 more source
Advanced Science, EarlyView.A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min +6 more
wiley +1 more source
Sequential Quantitative Trait Locus Mapping in Experimental Crosses
Statistical Applications in Genetics and Molecular Biology, 2007 The etiology of complex diseases is heterogeneous. The presence of risk alleles in one or more genetic loci affects the function of a variety of intermediate biological pathways, resulting in the overt expression of disease. Hence, there is an increasing focus on identifying the genetic basis of disease by systematically studying phenotypic traits ...
Satagopan, J M, Sen, S, Churchill, G A
openaire +3 more sources
Advanced Science, EarlyView.We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun +5 more
wiley +1 more source
Novel Resampling Improves Statistical Power for Multiple-Trait QTL Mapping
G3: Genes, Genomes, Genetics, 2017 Multiple-trait analysis typically employs models that associate a quantitative trait locus (QTL) with all of the traits. As a result, statistical power for QTL detection may not be optimal if the QTL contributes to the phenotypic variation in only a ...
Riyan Cheng +2 more
doaj +1 more source