Results 61 to 70 of about 3,713,868 (299)

SUP: an extension to SLINK to allow a larger number of marker loci to be simulated in pedigrees conditional on trait values

BMC Genetics, 2006
Background With the recent advances in high-throughput genotyping technologies that allow for large-scale association mapping of human complex traits, promising statistical designs and methods have been emerging.
Lemire Mathieu
doaj   +1 more source

A major genetic locus in Trypanosoma brucei is a determinant of host pathology [PDF]

, 2009
The progression and variation of pathology during infections can be due to components from both host or pathogen, and/or the interaction between them. The influence of host genetic variation on disease pathology during infections with trypanosomes has ...
C. Michael R. Turner, Andy Tait, Tait Andy, Liam J Morrison, McLellan Sarah, C Michael R Turner, Annette MacLeod, Liam J. Morrison, Turner, C.M.R., Sweeney Lindsay, MacLeod Annette, Lindsay Sweeney, MacLeod, A., McLellan, S., MacLeod, Annette, Tait, Andy, Morrison, L.J., McLellan, Sarah, Turner, C Michael R, Sweeney, Lindsay, Morrison Liam J., Sweeney, L., Turner C. Michael R., Morrison, Liam J; id_orcid, Tait, A., Sarah McLellan   +25 more
core   +1 more source

Genetic structure and molecular mechanism underlying the stalk lodging traits in maize (Zea mays L.)

Computational and Structural Biotechnology Journal, 2023
Stalk lodging seriously affects yield and quality of crops, and it can be caused by several factors, such as environments, developmental stages, and internal chemical components of plant stalks.
Shuai Wang, Huangai Li, Zhenying Dong, Cheng Wang, Xun Wei, Yan Long, Xiangyuan Wan   +6 more
doaj   +1 more source

A Latent Variable Approach to Multivariate Quantitative Trait Loci [PDF]

, 2010
A novel approach based on latent variable modelling is presented for the analysis of multivariate quantitative and qualitative trait loci. The approach is general in the sense that it enables the joint analysis of many kinds of quantitative and ...
Päivi Komulainen, Outi Savolainen, Mikko J. Sillanpää, Bob O'Hara   +3 more
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Detection of QTLs controlling heading date in the process of rice development at two environments

浙江大学学报. 农业与生命科学版, 2002
Heading date (HD) is a major determinant of the regional and seasonal adaptation of rice varieties. In order to elucidate the quantitative trait loci (QTL) for HD in the process of rice development, a doubled haploid (DH) population was employed to map ...
BAO Jin-song, BAO Zhi-yi, HE Ping, ZHU Li-huang   +3 more
doaj   +1 more source

Expression quantitative trait locus studies in the era of single-cell omics

Frontiers in Genetics, 2023
Genome-wide association studies have revealed that the regulation of gene expression bridges genetic variants and complex phenotypes. Profiling of the bulk transcriptome coupled with linkage analysis (expression quantitative trait locus (eQTL) mapping ...
Jie Luo, Xinyi Wu, Yuan Cheng, Guang Chen, Jian Wang, Xijiao Song   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Integrative analyses of genetic variation in enzyme activities of primary carbohydrate metabolism reveal distinct modes of regulation in Arabidopsis thaliana [PDF]

, 2008
Background Plant primary carbohydrate metabolism is complex and flexible, and is regulated at many levels. Changes of transcript levels do not always lead to changes in enzyme activities, and these do not always affect metabolite levels and fluxes.
Fu, Jingyuan, Vreugdenhil, Dick, Fu, Jingyuan; id_orcid, Keurentjes, Joost Jb, Keurentjes, J. J. B., Steinhauser, Marie-Caroline, Koornneef, Maarten, Koornneef, M., Steinhauser, M. C., Steinhauser, M., Steinhauser, C., Keurentjes, Joost J. B., Keurentjes, J., Gibon, Y., Keurentjes, J.J.B., Sulpice, R., Gibon, Yves, Stitt, M., Steinhauser, M.C., Sulpice, Ronan, Vreugdenhil, D., Fu, J. Y., Fu, J., Stitt, Mark   +23 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source