The gene's eye-view of quantitative genetics [PDF]
arXivModelling the evolution of a continuous trait in a biological population is one of the oldest problems in evolutionary biology, which led to the birth of quantitative genetics. With the recent development of GWAS methods, it has become essential to link the evolution of the trait distribution to the underlying evolution of allelic frequencies at many ...
arxiv
A Pattern Discovery-Based Method for Detecting Multi-Locus Genetic Association [PDF]
arXiv, 2007 Methods to effectively detect multi-locus genetic association are becoming increasingly relevant in the genetic dissection of complex trait in humans. Current approaches typically consider a limited number of hypotheses, most of which are related to the effect of a single locus or of a relatively small number of neighboring loci on a chromosomal region.
arxiv
Derivation of the Shrinkage Estimates of Quantitative Trait Locus Effects [PDF]
Genetics, 2007 AbstractThe shrinkage estimate of a quantitative trait locus (QTL) effect is the posterior mean of the QTL effect when a normal prior distribution is assigned to the QTL. This note gives the derivation of the shrinkage estimate under the multivariate linear model.
openaire +3 more sources
Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22. [PDF]
, 1996 Da Wu +12 more
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Localization of multiple pleiotropic genes for lipoprotein metabolism in baboons[S]
Journal of Lipid Research, 2009 We employed a novel approach to identify the key loci that harbor genes influencing lipoprotein metabolism in approximately 2,000 pedigreed baboons fed various diets differing in levels of fat and cholesterol.
David L. Rainwater +4 more
doaj
Long and short range multi-locus QTL interactions in a complex trait of yeast [PDF]
arXiv, 2015 We analyse interactions of Quantitative Trait Loci (QTL) in heat selected yeast by comparing them to an unselected pool of random individuals. Here we re-examine data on individual F12 progeny selected for heat tolerance, which have been genotyped at 25 locations identified by sequencing a selected pool [Parts, L., Cubillos, F. A., Warringer, J., Jain,
arxiv
Universality and predictability in molecular quantitative genetics [PDF]
arXiv, 2013 Molecular traits, such as gene expression levels or protein binding affinities, are increasingly accessible to quantitative measurement by modern high-throughput techniques. Such traits measure molecular functions and, from an evolutionary point of view, are important as targets of natural selection. We review recent developments in evolutionary theory
arxiv
Human Pedigree-Based Quantitative-Trait–Locus Mapping: Localization of Two Genes Influencing HDL-Cholesterol Metabolism [PDF]
, 1999 Laura Almasy +9 more
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Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering
Aggregate, EarlyView.Biomaterials offer a promising solution for cell transplantation in the central nervous system by creating a protective environment that enhances cell survival, integration, and functional recovery in preclinical models of neurological disorders. ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and ...
Yun Tang +3 more
wiley +1 more source
A Quantitative Trait Locus in Major Histocompatibility Complex Determining Latent Period of Mouse Lymphomas [PDF]
, 1996 Toshiyuki Kamoto +6 more
openalex +1 more source