Results 131 to 140 of about 283,140 (381)
Likelihood Ratio Test process for Quantitative Trait Loci detection. [PDF]
We consider the likelihood ratio test (LRT) process related to the test of the absence of QTL on the interval [0,T] representing a chromosome (a QTL denotes a quantitative trait locus, i.e. a gene with quantitative effect on a trait).
Azaïs, Jean-Marc+2 more
core +2 more sources
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song+37 more
wiley +1 more source
Expression quantitative trait locus mapping in well-watered and drying soil revealed differential gene expression resulting from standing genetic variation, environmental condition, and gene × environment interactions. Genomic features were then shown to
D. Lowry+8 more
semanticscholar +1 more source
A new method for Quantitative Trait Loci Detection [PDF]
We consider the likelihood ratio test (LRT) process related to the test of the absence of QTL on the interval $[0,T]$ representing a chromosome (a QTL denotes a quantitative trait locus, i.e. a gene with quantitative effect on a trait).
DELMAS, Céline, Rabier, Charles-Elie
core +1 more source
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich+8 more
wiley +1 more source
Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q. [PDF]
A. V. Lembertas+10 more
openalex +1 more source
Semiparametric Quantitative-Trait-Locus Mapping: II. on Censored Age-at-Onset [PDF]
In genetic studies, the variation in genotypes may not only affect different inheritance patterns in qualitative traits, but may also affect the age-at-onset as quantitative trait.
Chen, Ying Qing+2 more
core +1 more source
Stability and response of polygenic traits to stabilizing selection and mutation
When polygenic traits are under stabilizing selection, many different combinations of alleles allow close adaptation to the optimum. If alleles have equal effects, all combinations that result in the same deviation from the optimum are equivalent ...
Barton+8 more
core +1 more source
Derivation of the Shrinkage Estimates of Quantitative Trait Locus Effects [PDF]
AbstractThe shrinkage estimate of a quantitative trait locus (QTL) effect is the posterior mean of the QTL effect when a normal prior distribution is assigned to the QTL. This note gives the derivation of the shrinkage estimate under the multivariate linear model.
openaire +3 more sources
NDRG1 drives lactate accumulation and histone lactylation in lung adenocarcinoma, promoting immunosuppression via M2 macrophage polarization and CD8⁺ T cell inhibition. High NDRG1 expression correlates with poor prognosis, an immunosuppressive microenvironment, and immunotherapy resistance.
Gujie Wu+14 more
wiley +1 more source