Results 161 to 170 of about 141,382 (327)

High-dimensional covariance regression with application to co-expression QTL detection [PDF]

open access: yesarXiv
While covariance matrices have been widely studied in many scientific fields, relatively limited progress has been made on estimating conditional covariances that permits a large covariance matrix to vary with high-dimensional subject-level covariates.
arxiv  

Blocking ITGA5 potentiates the efficacy of anti‐PD‐1 therapy on glioblastoma by remodeling tumor‐associated macrophages

open access: yesCancer Communications, EarlyView.
Abstract Background Glioblastoma (GBM) is largely refractory to antibodies against programmed cell death 1 (anti‐PD‐1) therapy. Fully understanding the cellular heterogeneity and immune adaptations in response to anti‐PD‐1 therapy is necessary to design more effective immunotherapies for GBM.
Rongrong Zhao   +11 more
wiley   +1 more source

A convex formulation of covariate-adjusted Gaussian graphical models via natural parametrization [PDF]

open access: yesarXiv
Gaussian graphical models (GGMs) are widely used for recovering the conditional independence structure among random variables. Recently, several key advances have been made to exploit an additional set of variables for better estimating the GGMs of the variables of interest.
arxiv  

Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2‐mediated increase of SOAT2 RNA methylation

open access: yesCancer Communications, EarlyView.
Abstract Background Hepatocellular carcinoma (HCC) is a deadly malignancy known for its ability to evade immune surveillance. NOP2/Sun RNA methyltransferase family member 2 (NSUN2), an RNA methyltransferase involved in carcinogenesis, has been associated with immune evasion and energy metabolism reprogramming.
Jinhua Jiang   +6 more
wiley   +1 more source

Inorganic Nanoparticles in Reproduction Biology: Opportunities and Challenges

open access: yesChemPlusChem, Accepted Article.
The development of inorganic metal and metal oxide nanoparticles (MNPs) has attracted significant attention in biomedical and biotechnological fields. An emerging field in this context is the use of MNPs in reproduction biology. Here, we review the development of MNPs in the field of reproduction by focusing on their interactions with highly delicate ...
Stephan Barcikowski   +3 more
wiley   +1 more source

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