Results 171 to 180 of about 361,741 (406)

Targeted Intervention Strategies for Maternal–Offspring Transmission of Christensenellaceae in Pigs via a Deep Learning Model

Advanced Science, EarlyView.
This study deciphers maternal‐driven microbial transmission in pigs using a deep learning model (maternal–offspring microbial transmission model), identifying Christensenellaceae R‐7 group as a key transmitted taxon. Filtered galacto‐oligosaccharides‐targeted Christensenellaceae R‐7 group alters offspring microbial functions via maternal ...
Haibo Shen, Xiaokang Ma, Longlin Zhang, Hao Li, Jichang Zheng, Shengru Wu, Ke Zuo, Yulong Yin, Jing Wang, Bie Tan   +9 more
wiley   +1 more source

Human Pedigree-Based Quantitative-Trait–Locus Mapping: Localization of Two Genes Influencing HDL-Cholesterol Metabolism [PDF]

, 1999
Laura Almasy, James E. Hixson, David L. Rainwater, Shelley Cole, Jeff T. Williams, Michael C. Mahaney, John L. VandeBerg, Michael P. Stern, Jean W. MacCluer, John Blangero   +9 more
openalex   +1 more source

Antagonistic Ghd7‐OsNAC42 Complexes Modulate Carbon and Nitrogen Metabolism to Achieves Superior Quality and High Yield in Rice

Advanced Science, EarlyView.
The complex centered on Ghd7 binds to numerous carbon and nitrogen metabolism genes on the genome through the corresponding motifs and transactivates the transcriptional expression of these carbon and nitrogen metabolism genes. With the assistance of OsNAC42 and other unknown Ghd7‐interacting proteins, this complex can regulate different metabolic ...
Guangming Lou, Pingli Chen, Pingbo Li, Haozhou Gao, Jiawang Xiong, Shanshan Wan, Yuanyuan Zheng, Yufu Wang, Mufid Alam, Yingnanjun Chen, Lei Wang, Jingjing Bai, Xuan Tan, Wenting Rao, Bian Wu, Hao Zhou, Yanhua Li, Guanjun Gao, Qinglu Zhang, Jinghua Xiao, Xianghua Li, Xuelei lai, Qifa Zhang, Yuqing He   +23 more
wiley   +1 more source

Localization of multiple pleiotropic genes for lipoprotein metabolism in baboons[S]

Journal of Lipid Research, 2009
We employed a novel approach to identify the key loci that harbor genes influencing lipoprotein metabolism in approximately 2,000 pedigreed baboons fed various diets differing in levels of fat and cholesterol.
David L. Rainwater, Laura A. Cox, Jeffrey Rogers, John L. VandeBerg, Michael C. Mahaney   +4 more
doaj  

The statistical mechanics of a polygenic characterunder stabilizing selection, mutation and drift

, 2010
By exploiting an analogy between population genetics and statistical mechanics, we study the evolution of a polygenic trait under stabilizing selection, mutation, and genetic drift.
Abramowitz M., Barton N. H., Bulmer M. G., Bürger R., Crow J. F., Ewens W. J., Falconer D. S., Gavrilets S., Harold P. de Vladar, Kimura M., Kondrashov A. S., Lynch M., Lynch M., Nick H. Barton, Rattray M., Turelli M., Turelli M., Wright S., Wright S.   +18 more
core   +2 more sources

A Quantitative Trait Locus in Major Histocompatibility Complex Determining Latent Period of Mouse Lymphomas [PDF]

, 1996
Toshiyuki Kamoto, Hayase Shisa, Abujiang Pataer, Л. Лу, Osamu Yoshida, Yoshihiro Yamada, Hiroshi Hiai   +6 more
openalex   +1 more source

Quantitative Trait Locus

Definitions, 2020

semanticscholar   +1 more source

PRMT3‐Mediated H4R3me2a Promotes Primary Age‐Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron

Advanced Science, EarlyView.
This study identifies PRMT3‐mediated H4R3me2a as a critical driver of tau hyperphosphorylation in primary age‐related tauopathy. Mechanistic insights reveal that the PRMT3/H4R3me2a/miR‐448 axis suppresses IGF1R expression via epigenetic regulation, further dysregulating the PI3K/AKT/GSK3β pathway.
Haotian Liu, Xinnan Liu, Fengyuan Tian, Yashuang Chen, Jingying Li, Xue Wang, Wenying Qiu, Xia Wang, Chao Ma, Wei Ge   +9 more
wiley   +1 more source

Test of candidate gene–quantitative trait locus association applied to fatness in mice [PDF]

, 1998
Peter D. Keightley, Kenneth H Morris, Akira Ishikawa, Victoria M. Falconer, Fiona Oliver   +4 more
openalex   +1 more source

RUNX1/SLAMF3 Axis Drives Immunosuppression to Contribute to Colorectal Cancer Liver Metastasis by Blocking Phagocytosis and Depleting C1QC+ Tumor‐Associated Macrophages

Advanced Science, EarlyView.
This study identifies the RUNX1/SLAMF3 axis as a key driver of colorectal cancer liver metastasis (CRLM). SLAMF3 suppresses macrophage phagocytosis and depletes C1QC⁺ tumor‐associated macrophages, promoting an immunosuppressive microenvironment. Targeting this axis restores macrophage and CD8⁺ T cell activity and reduces metastasis.
Yinheng Luo, Xiaoli Jin, Lan Huang, Dejia Zeng, Nan Zhang, Shiyu Tang, Shu Luo, Samina Ejaz Syed, Ruiwu Dai, Qiu Li, Shufang Liang   +10 more
wiley   +1 more source