Results 21 to 30 of about 361,741 (406)

Cell Specific eQTL Analysis without Sorting Cells. [PDF]

PLoS Genetics, 2015
The functional consequences of trait associated SNPs are often investigated using expression quantitative trait locus (eQTL) mapping. While trait-associated variants may operate in a cell-type specific manner, eQTL datasets for such cell-types may not ...
Harm-Jan Westra, Danny Arends, Tõnu Esko, Marjolein J Peters, Claudia Schurmann, Katharina Schramm, Johannes Kettunen, Hanieh Yaghootkar, Benjamin P Fairfax, Anand Kumar Andiappan, Yang Li, Jingyuan Fu, Juha Karjalainen, Mathieu Platteel, Marijn Visschedijk, Rinse K Weersma, Silva Kasela, Lili Milani, Liina Tserel, Pärt Peterson, Eva Reinmaa, Albert Hofman, André G Uitterlinden, Fernando Rivadeneira, Georg Homuth, Astrid Petersmann, Roberto Lorbeer, Holger Prokisch, Thomas Meitinger, Christian Herder, Michael Roden, Harald Grallert, Samuli Ripatti, Markus Perola, Andrew R Wood, David Melzer, Luigi Ferrucci, Andrew B Singleton, Dena G Hernandez, Julian C Knight, Rossella Melchiotti, Bernett Lee, Michael Poidinger, Francesca Zolezzi, Anis Larbi, De Yun Wang, Leonard H van den Berg, Jan H Veldink, Olaf Rotzschke, Seiko Makino, Veikko Salomaa, Konstantin Strauch, Uwe Völker, Joyce B J van Meurs, Andres Metspalu, Cisca Wijmenga, Ritsert C Jansen, Lude Franke   +57 more
doaj   +4 more sources

A quantitative trait locus analysis of personality in wild bighorn sheep [PDF]

Ecology and Evolution, 2013
Personality, the presence of persistent behav105 ioral differences among individuals over time or contexts, potentially has important ecological and evolutionary consequences. However, a lack of knowledge about its genetic architecture limits our ability
J. Poissant, D. Réale, J.G.A. Martin, M. Festa‐Bianchet, D.W. Coltman   +4 more
doaj   +3 more sources

Expression quantitative trait locus studies in the era of single-cell omics [PDF]

Frontiers in Genetics, 2023
Genome-wide association studies have revealed that the regulation of gene expression bridges genetic variants and complex phenotypes. Profiling of the bulk transcriptome coupled with linkage analysis (expression quantitative trait locus (eQTL) mapping ...
Jie Luo, Xinyi Wu, Yuan Cheng, Guang Chen, Jian Wang, Xijiao Song   +5 more
doaj   +2 more sources

Expression quantitative trait locus analysis for translational medicine

Genome Medicine, 2015
Expression quantitative trait locus analysis has emerged as an important component of efforts to understand how genetic polymorphisms influence disease risk and is poised to make contributions to translational medicine.
G. Gibson, J. Powell, U. Marigorta
semanticscholar   +4 more sources

A Quantitative Trait Locus Influencing Anxiety in the Laboratory Rat [PDF]

Genome Research, 2002
A critical test for a gene that influences susceptibility to fear in animals is that it should have a consistent pattern of effects across a broad range of conditioned and unconditioned models of anxiety. Despite many years of research, definitive evidence that genetic effects operate in this way is lacking.
Alberto Fernández‐Teruel
openalex   +5 more sources

Dissecting the Genetic Basis of Yield Traits and Validation of a Novel Quantitative Trait Locus for Grain Width and Weight in Rice [PDF]

Plants
Grain yield in rice is a complex trait and it is controlled by a number of quantitative trait loci (QTL). To dissect the genetic basis of rice yield, QTL analysis for nine yield traits was performed using an F2 population containing 190 plants, which was
Man Yin, Xiaohong Tong, Jinyu Yang, Yichen Cheng, Panpan Zhou, Guan Li, Yifeng Wang, Jiezheng Ying   +7 more
doaj   +2 more sources

Expression quantitative trait locus mapping of extracellular microRNAs in human plasma [PDF]

iScience
Summary: MicroRNAs, crucial in regulating protein-coding gene expression, are implicated in various diseases. We performed a genome-wide association study of plasma miRNAs (ex-miRNAs) in 3,743 Framingham Heart Study (FHS) participants and identified 1 ...
Tianxiao Huan, Roby Joehanes, Jian Rong, Ming-Huei Chen, Rima Mustafa, Abbas Dehghan, Mohsen Ghanbari, Hannah Karlin, Shih-Jen Hwang, Paul Courchesne, Martin G. Larson, Andrew D. Johnson, Jane E. Freedman, Daniel Levy   +13 more
doaj   +2 more sources

Hd1, a Major Photoperiod Sensitivity Quantitative Trait Locus in Rice, Is Closely Related to the Arabidopsis Flowering Time Gene CONSTANS

The Plant Cell, 2000
Masahiro Yano, Yūichi Katayose, Motoyuki Ashikari, Utako Yamanouchi, Lisa Monna, Takuichi Fuse, Tomoya Baba, Kimiko Yamamoto, Yosuke Umehara, Yoshiaki Nagamura, Takuji Sasaki   +10 more
openalex   +3 more sources

Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype.

PLoS Biology, 2007
Deficits in prepulse inhibition (PPI) are a biological marker for schizophrenia. To unravel the mechanisms that control PPI, we performed quantitative trait loci (QTL) analysis on 1,010 F2 mice derived by crossing C57BL/6 (B6) animals that show high PPI ...
Akiko Watanabe, Tomoko Toyota, Yuji Owada, Takeshi Hayashi, Yoshimi Iwayama, Miho Matsumata, Yuichi Ishitsuka, Akihiro Nakaya, Motoko Maekawa, Tetsuo Ohnishi, Ryoichi Arai, Katsuyasu Sakurai, Kazuo Yamada, Hisatake Kondo, Kenji Hashimoto, Noriko Osumi, Takeo Yoshikawa   +16 more
doaj   +4 more sources

Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases

Nature Genetics, 2023
Brain expression quantitative trait locus (eQTL) and network analyses encompassing 8,613 RNA-sequencing samples from 14 eQTL datasets reveal downstream effects and putative drivers for brain-related diseases.
N. de Klein, E. Tsai, Martijn Vochteloo, D. Baird, Yunfeng Huang, Chia-Yen Chen, Sipko van Dam, Patrick Deelen, O. Bakker, Omar El Garwany, Zhengyu Ouyang, Eric Marshall, M. Zavodszky, W. van Rheenen, Mark K. Bakker, J. Veldink, Tom R. Gaunt, H. Runz, L. Franke, H. Westra   +19 more
semanticscholar   +1 more source