Results 341 to 350 of about 283,140 (381)

Quantitative trait locus mapping for atherosclerosis susceptibility

Current Opinion in Lipidology, 2003
Atherosclerosis is a complex trait with both environmental and genetic aspects. Although some progress has been made in defining genes associated with atherosclerosis in humans, animal models have been useful in learning about pathways and genes involved in atherogenesis.
openaire   +2 more sources

Prospects for quantitative trait locus methodology in gerontology

Experimental Gerontology, 1997
The remarkable advances in mapping of genomes have made it feasible to search among the hitherto anonymous polygenes of complex systems for loci of intermediate effect size (quantitative trait loci-QTL). Pursuing the strategy of identifying these QTL in complex systems will open the possibility of exploring the genetic architecture and the anatomical ...
openaire   +3 more sources

Localization of a Quantitative Trait Locus via a Bayesian Approach

Biometrics, 2000
Summary. A Bayesian approach to the direct mapping of a quantitative trait locus (QTL), fully utilizing information from multiple linked gene markers, is presented in this paper. The joint posterior distribution (a mixture distribution modeling the linkage between a biallelic QTL and N gene markers) is computationally challenging and invites ...
George, A. W., Mengersen, K. L., Davis, G. P.   +2 more
openaire   +4 more sources

Quantitative Trait Locus for Reading Disability on Chromosome 6

Science, 1994
Interval mapping of data from two independent samples of sib pairs, at least one member of whom was reading disabled, revealed evidence for a quantitative trait locus (QTL) on chromosome 6. Results obtained from analyses of reading performance from 114 sib pairs genotyped for DNA markers localized the QTL to 6p21.3.
Lon R. Cardon, John C. DeFries, David W. Fulker, Bruce F. Pennington, Shelley D. Smith, William J. Kimberling   +5 more
openaire   +3 more sources

Mapping of a quantitative trait locus for morphine withdrawal severity

Mammalian Genome, 2004
Chronic morphine exposure results in physical dependence, manifested by physical symptoms during naloxone-precipitated withdrawal. Jumping frequency is widely considered the most sensitive and reliable index of withdrawal intensity in mice. Inbred mouse strains surveyed for naloxone-precipitated withdrawal display large and significant strain ...
Kest, B, Palmese, C A, Juni, A, Chesler, E J, Mogil, J S   +4 more
openaire   +4 more sources

A major quantitative trait locus conferring subgynoecy in cucumber

Theoretical and Applied Genetics, 2015
A major QTL conditioning high degree of femaleness in cucumber was identified by marker analysis and next generation sequencing. Cucumber (Cucumis sativus L.) is a model species for sex determination studies, and its yield is associated with the degree of femaleness.
Qian Zhou, Fengjiao Bu, Zhonghua Zhang, Dongli Gao, Qiuxiang Shi, Sanwen Huang, Huiming Chen   +6 more
openaire   +3 more sources

Quantitative Trait Locus Analysis Using J/qtl

2009
Quantitative trait locus (QTL) analysis is a statistical method to link phenotypes with regions of the genome that affect the phenotypes in a mapping population. R/qtl is a powerful statistical program commonly used for analyzing rodent QTL crosses, but R/qtl is a command line program that can be difficult for novice users to run.
Smith, R, Sheppard, K, DiPetrillo, K, Churchill, G   +3 more
openaire   +3 more sources

Quantitative Trait Locus (QTL) Mapping in Aging Systems

2007
Understanding the genetic basis of the effects of aging on the decline in the immune response is an enormous undertaking. The most prominent age-related change in the immune system is thymic involution. This chapter will focus on the use of C57BL/6 J X DBA/2 J (BXD) recombinant inbred (RI) strains of mice to map genetic loci associated with age-related
Gary Van Zant, Nengjun Yi, Hui-Chen Hsu, Robert W. Williams, Lu Lu, John D. Mountz   +5 more
openaire   +3 more sources

Quantitative Trait Locus (QTL) Analysis 1

Journal of Natural Resources and Life Sciences Education, 2005
This is the first of a two-part series that describes the methods and uses of QTL analysis. Understanding the genetic control of quantitative traits helps plant breeders improve crop yield, disease resistance, end-use quality, and other important characteristics.
openaire   +2 more sources

Quantitative Trait Locus (QTL) Analysis 2

Journal of Natural Resources and Life Sciences Education, 2005
This is the second of a two-part series that describes the methods and uses of QTL analysis. Objectives and Overview Quantitative trait locus (QTL) analysis is a methodology that combines DNA marker and phenotypic trait data to locate and characterize genes that influence quantitative traits.
openaire   +2 more sources