High-dimensional covariance regression with application to co-expression QTL detection [PDF]
arXivWhile covariance matrices have been widely studied in many scientific fields, relatively limited progress has been made on estimating conditional covariances that permits a large covariance matrix to vary with high-dimensional subject-level covariates.
arxiv
Rapid adaptation of a polygenic trait after a sudden environmental shift [PDF]
Genetics 206, 389-406 (2017), 2016 Although a number of studies have shown that natural and laboratory populations initially well-adapted to their environment can evolve rapidly when conditions suddenly change, the dynamics of rapid adaptation are not well understood. Here a population genetic model of polygenic selection is analyzed to describe the short-term response of a quantitative
arxiv
Genetic Architecture of Immune Cell DNA Methylation in the Rhesus Macaque
Molecular Ecology, EarlyView.ABSTRACT Genetic variation that impacts gene regulation, rather than protein function, can have strong effects on trait variation both within and between species. Epigenetic mechanisms, such as DNA methylation, are often an important intermediate link between genotype and phenotype, yet genetic effects on DNA methylation remain understudied in natural ...
Christina E. Costa +12 more
wiley +1 more source
Generalized Admixture Mapping for Complex Traits [PDF]
arXiv, 2011 Admixture mapping is a popular tool to identify regions of the genome associated with traits in a recently admixed population. Existing methods have been developed primarily for identification of a single locus influencing a dichotomous trait within a case-control study design. We propose a generalized admixture mapping (GLEAM) approach, a flexible and
arxiv
A genome-wide quantitative trait locus (QTL) linkage scan of NEO personality factors in Latino families segregating bipolar disorder [PDF]
, 2017 Byung Dae Lee +12 more
openalex +1 more source
Structural Variants Contribute to Phenotypic Variation in Maize
Molecular Ecology, EarlyView.ABSTRACT Comprehensively identifying the loci shaping trait variation has been challenging, in part because standard approaches often miss many types of genetic variants. Structural variants (SVs), especially transposable elements (TEs), are likely to affect phenotypic variation but we lack methods that can detect polymorphic SVs and TEs using short ...
Nathan S. Catlin +5 more
wiley +1 more source
Genetic Fine‐Mapping of a Quantitative Trait Locus (QTL) Associated with Embryogenic Tissue Culture Response and Plant Regeneration Ability in Maize (Zea mays L.) [PDF]
, 2018 Stella Salvo +5 more
openalex +1 more source
Research Advances and Perspectives on Early Flowering Traits in Cucumber
PlantsEarly flowering refers to the phenomenon in which the first flower appears in fewer days than normal, regardless of the sex of the flower. It is a significant feature impacting the early maturity and economic yield of cucumbers. The early flowering trait
Meidi Zhang +3 more
doaj +1 more source
Evolution of Hybrid Inviability Associated With Chromosome Fusions
Molecular Ecology, EarlyView.ABSTRACT Chromosomal rearrangements, such as inversions, have received considerable attention in the speciation literature due to their hampering effects on recombination. Less is known about how other rearrangements, such as chromosome fissions and fusions, can affect the evolution of reproductive isolation. Here, we use crosses between populations of
Jesper Boman +4 more
wiley +1 more source