Results 71 to 80 of about 144,128 (313)

Quantitative Trait Locus Analysis of Seed Germination and Seedling Vigor in Brassica rapa Reveals QTL Hotspots and Epistatic Interactions

Frontiers in Plant Science, 2015
The genetic basis of seed germination and seedling vigor is largely unknown in Brassica species. We performed a study to evaluate the genetic basis of these important traits in a B. rapa doubled haploid population from a cross of a yellow-seeded oil-type
R. Basnet, Anita Duwal, D. Tiwari, D. Xiao, S. Monakhos, Johan Bucher, R. Visser, S. Groot, G. Bonnema, C. Maliepaard   +9 more
semanticscholar   +1 more source

Mapping genetic determinants of host susceptibility to Pseudomonas aeruginosa lung infection in mice. [PDF]

, 2016
Background: P. aeruginosa is one of the top three causes of opportunistic human bacterial infections. The remarkable variability in the clinical outcomes of this infection is thought to be associated with genetic predisposition.
A Bragonzi, A Bragonzi, A Bragonzi, A Corken, A Darvasi, Alessandra Bragonzi, C Cigana, C Morissette, C Morissette, CC Elbers, Cristina Cigana, CS Haley, D Nguyen, DL Demeo, DM Menge, E Amiel, EE Smith, F Iraqi, F Iraqi, FA Iraqi, FA Iraqi, Fuad A. Iraqi, GA Churchill, GR Cutting, GS Cooke, H Shinohara, I Bianconi, Ida De Fino, J Dupuis, JB Lyczak, JE Pennington, JM Collaco, K Sapru, K Tremblay, Karl W. Broman, KW Broman, L Guillot, LD Hazlett, Lorenza Spagnuolo, M Hernandez-Valladares, M Munoz, M Simone De, M Tam, M Verdrengh, MA Jong de, Maura De Simone, ML Drumm, N Lorè, NI Lore, Nicola Ivan Lorè, R Mashima, R Mashima, R Williams, S Aerts, S Gruenheid, S Worgall, SL Cheng, SL Gellatly, SM Vidal, TT Wu, V DeRose, Y Moreau, Y Zhan   +62 more
core   +1 more source

GEO combined with quantitative protein trait loci identify causative proteins in hypertrophic cardiomyopathy

ESC Heart Failure, EarlyView.
Abstract Aims Hypertrophic cardiomyopathy (HCM) is a rare genetic heart disease characterized by a limited patient population and scarce research and treatment resources. This study aimed to identify HCM‐associated proteins by integrating cardiac tissue data from the Gene Expression Omnibus (GEO) database with the latest protein quantitative trait ...
Bo Li, Xu Zhao, Yan Ding, Yi Zhang
wiley   +1 more source

High Dimensional Gaussian Graphical Regression Models with Covariates [PDF]

arXiv, 2020
Though Gaussian graphical models have been widely used in many scientific fields, relatively limited progress has been made to link graph structures to external covariates. We propose a Gaussian graphical regression model, which regresses both the mean and the precision matrix of a Gaussian graphical model on covariates. In the context of co-expression
arxiv  

Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans [PDF]

, 2017
Compelling evidence for the inherited nature of essential hypertension has led to extensive research in rats and humans. Rats have served as the primary model for research on the genetics of hypertension resulting in identification of genomic regions ...
Allbutt TC, Bina Joe, Biron P, Biron P, Bright R, Cook HW, Dublin LI, Dublin LI, Dupont J, Esunge PM, Felts JH, Garrod AE, Garrod AE, Garrod AE, Hamilton M, Hamilton M, Hamilton M, Joe B, Koffler M, Korner PI, Kuijpers MH, Lee YH, Lewis O, Markel’ AL, Matsukawa N, Mo R, Ohno Y, Pickering GW, Pravenec M, Sandosh Padmanabhan, Schlager G, Shear CL, Shiozawa M, Smolarek I, Zhang Y   +34 more
core   +1 more source

Multiomics insight into the role of glucagon‐like peptide‐1 receptor agonists in heart failure

ESC Heart Failure, EarlyView.
Graphical abstract of the multiomics insight into the role of GLP1Ra in cardiovascular diseases and the underlying pathway. GLP1Ra, glucagon‐like peptide‐1 receptor agonist. Abstract Aims Cardiovascular diseases, such as atrial fibrillation, coronary artery disease, heart failure (HF) and ischaemic stroke, are leading causes of death globally and exert
Yuhang Tao, Qi Liu, Yuxing Wang, Yingchao Gong, Mingying Xu, Ruhong Jiang, Kai Zhang   +6 more
wiley   +1 more source

Role of genetic polymorphisms in transgenerational inheritance in budding yeast [PDF]

Genomics, 106: 23-29 (2015), 2013
Transgenerational inheritance of a trait is presumably affected by both genetic and environmental factors but remains poorly understood. We studied the effect of genetic polymorphisms on transgenerational inheritance of yeast segregants that were derived from a cross between a laboratory strain and a wild strain of Saccharomyces cerevisiae.
arxiv   +1 more source

Genetic analysis of safflower domestication. [PDF]

, 2014
BackgroundSafflower (Carthamus tinctorius L.) is an oilseed crop in the Compositae (a.k.a. Asteraceae) that is valued for its oils rich in unsaturated fatty acids.
Bowers, John E, Burke, John M, Michelmore, Richard W, Pearl, Stephanie A, Reyes-Chin-Wo, Sebastian   +4 more
core   +1 more source

Comparative mapping reveals quantitative trait loci that affect spawning time in coho salmon (Oncorhynchus kisutch)

Genetics and Molecular Biology, 2012
Spawning time in salmonids is a sex-limited quantitative trait that can be modified by selection. In rainbow trout (Oncorhynchus mykiss), various quantitative trait loci (QTL) that affect the expression of this trait have been discovered.
Cristian Araneda, Nelson F. Díaz, Gilda Gomez, María Eugenia López, Patricia Iturra   +4 more
doaj   +1 more source

Multiallelic models for QTL mapping in diverse polyploid populations

BMC Bioinformatics, 2022
Quantitative trait locus (QTL) analysis allows to identify regions responsible for a trait and to associate alleles with their effect on phenotypes. When using biallelic markers to find these QTL regions, two alleles per QTL are modelled. This assumption
Alejandro Thérèse Navarro, Giorgio Tumino, Roeland E. Voorrips, Paul Arens, Marinus J. M. Smulders, Eric van de Weg, Chris Maliepaard   +6 more
doaj   +1 more source