Results 71 to 80 of about 837,128 (290)

Quantitative Trait Loci: A Meta-analysis [PDF]

Genetics, 2000
Abstract This article presents a method to combine QTL results from different independent analyses. This method provides a modified Akaike criterion that can be used to decide how many QTL are actually represented by the QTL detected in different experiments. This criterion is computed to choose between models with one, two, three, etc.,
Goffinet, Bruno, Gerber, Sophie
openaire   +3 more sources

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Agro-morphological traits-based genetic diversity assessment on oat (Avena sativa L.) genotypes in the central highlands of Ethiopia

All Life, 2023
The study aimed to estimate the extent of genetic variability, heritability, and expected genetic gain attributable to agro-morphological traits and to suggest an effective selection scheme and specify promising genotypes for future oat breeding programs.
Gezahagn Kebede, Walelign Worku, Fekede Feyissa, Habte Jifar   +3 more
doaj   +1 more source

The evolution of genetic architectures underlying quantitative traits

, 2013
In the classic view introduced by R. A. Fisher, a quantitative trait is encoded by many loci with small, additive effects. Recent advances in QTL mapping have begun to elucidate the genetic architectures underlying vast numbers of phenotypes across ...
Plotkin, Joshua B., Rajon, Etienne
core   +3 more sources

Copper–Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids

Advanced Healthcare Materials, EarlyView.
Ionic copper is investigated as a modulator of tumor spheroid growth and invasiveness in a 3D microfluidic glioblastoma model. Copper exposure alters metabolic activity, cytoskeletal organization, protrusion dynamics, and EMT‐related phenotypes in a dose‐ and timing‐dependent manner, revealing how copper bioavailability shapes tumor aggressiveness ...
Paula Guerrero‐López, Jose I. Garcia‐Peiro, Felipe Hornos, Jose L. Hueso, Jesus Santamaria, J. Manuel Garcia‐Aznar   +5 more
wiley   +1 more source

Mapping epistatic quantitative trait loci

BMC Genetics, 2014
How to map quantitative trait loci (QTL) with epistasis efficiently and reliably has been a persistent problem for QTL mapping analysis. There are a number of difficulties for studying epistatic QTL. Linkage can impose a significant challenge for finding epistatic QTL reliably. If multiple QTL are in linkage and have interactions, searching for QTL can
Laurie, Cecelia, Wang, Shengchu, Carlini-Garcia, Luciana Aparecida, Zeng, Zhao-Bang   +3 more
openaire   +2 more sources

CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads

Advanced Healthcare Materials, EarlyView.
In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura, Vincent Fung, Rachel VanKeulen‐Miller, Palas B. Tiwade, Owen S. Fenton   +4 more
wiley   +1 more source

The Olive tree from juvenility to maturity: Insight on the developmental changes over years and the genetic basis of vegetative and reproductive traits : W304 [PDF]

, 2013
Fruit trees productivity is closely linked to their development. Integrating architectural traits in breeding programs could optimise cultivation management and improve bearing regularity.
Ben Sadok, Inès, Costes, Evelyne, Garcia, Gilbert, Khadari, Bouchaib, Moutier, Nathalie   +4 more
core  

Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues

Advanced Materials, EarlyView.
A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad, Verena J. Kast, Dagmar Pette, Franziska Baenke, Daniel E. Stange, Carsten Werner, Daniela Loessner   +6 more
wiley   +1 more source

Marker-assisted selection for quantitative traits

Crop Breeding and Applied Biotechnology, 2011
Although thousands of scientific articles have been published on the subject of marker-assisted selection (MAS) and quantitative trait loci (QTL), the application of MAS for QTL in plant breeding has been restricted.
Ivan Schuster
doaj