Results 11 to 20 of about 238 (83)

Flow Cytometry: Advances, Challenges and Trends. [PDF]

Bioessays
Recent advances in flow cytometry span hardware, data processing, and AI‐driven analytics. Emerging modalitiesincluding spectral, imaging, mass, and nano/EV cytometryenable higher‐parameter and small‐particle detection. Integrated machine learning drives a shift from manual gating toward automated multi‐omics workflows.
Robinson JP, Gmyrek GB, Rajwa B.
europepmc   +2 more sources

Fluorinated Glycan Frameshifts: Automated Synthesis Expedites the Study of Glycan‐Protein Interactions by 19F‐BioNMR

Angewandte Chemie, EarlyView.
Given the prominence of 19F‐bioNMR in structural research, fluorinated glycans hold enormous potential in glycomimetic frameshift design. However, challenges associated with the stereocontrolled synthesis of these disruptive actors continue to frustrate advances. To address this, the automated synthesis of selectively C‐2 fluorinated glycans related to
James Suri, Christina Jordan, Charlotte S. Teschers, Kristina Schlangen, Simon H. Rüdisser, Alvar D. Gossert, Ryan Gilmour   +6 more
wiley   +2 more sources

Benzoyl‐Xanthenoxanthenes: Versatile Chromophores for Light‐Engaging Applications

Angewandte Chemie, Volume 138, Issue 7, 9 February 2026.
Oxidatively stable benzoyl‐fused peri‐xanthenoxanthene ribbons with NIR emission were synthesized. Their good spectral overlap enabled cascaded Förster resonance energy transfer (FRET) antennae in a nematic liquid crystal phase, achieving directional energy transfer.
Cristian De Luca, El Czar Galleposo, Rúben R. Ferreira, Chiara Puccinelli, Herwig Peterlik, Pradip Kumar Mondal, Laurens van Dam, Johannes C. B. Dietschreit, Yoshimichi Shimomura, Gen‐ichi Konishi, Davide Bonifazi   +10 more
wiley   +2 more sources

Triply Responsive Control of Ion Transport with an Artificial Channel Creates a Switchable AND to OR Logic Gate

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
We report a triply responsive artificial ion channel, showing tuneable activity, and responsive to three distinct stimuli ‐ light, pH, and ligand – which we use to formulate an AND to OR switchable molecular logic gate. Abstract Ion channels are ubiquitous in Nature, performing complex and essential tasks in our bodies. Synthetic chemists have begun to
Javid Ahmad Malla, Kharina J. Fenton, Adinarayana Bellamkonda, Samuel I. Fidler, Mark I. Wallace, Charlie T. McTernan   +5 more
wiley   +2 more sources

A Cathepsin B‐Triggered CO‐Releasing Molecule with a Non‐Toxic Metal Core for Targeted Tumor Delivery

Angewandte Chemie, Volume 138, Issue 1, 2 January 2026.
An iron‐based, enzyme‐triggered CO‐releasing molecule (ET‐CORM) is site‐specifically conjugated to the antibody trastuzumab. This novel ET‐CORM‐antibody conjugate releases carbon monoxide upon cleavage by the tumor‐associated protease cathepsin B. The construct enables selective intracellular CO delivery to HER2‐overexpressing and CatB‐expressing cells,
Inga Černauskienė, Eduardo Izquierdo‐García, Sarah Keller, Harley Betts, Kevin Cariou, Vicente Marchán, Gilles Gasser, Gonçalo J. L. Bernardes   +7 more
wiley   +2 more sources

Photocaged and Water‐Soluble Glucose Functionalization for Spatiotemporal Acidification Pathways

Helvetica Chimica Acta, EarlyView.
Light‐controlled glucose release from a water‐soluble coumarin photocage enables spatiotemporal acid generation in enzyme‐driven chemical reaction networks. ABSTRACT The spatiotemporal control of complex molecular systems, such as chemical reaction networks (CRNs), requires reagents and reactive species that can be activated both efficiently and ...
Nikolai Hempel, Michelle Szostak, Pol Besenius   +2 more
wiley   +1 more source

Development of Functional Coatings from PCL‐PEG Tetra‐Arm Amphiphilic Polymer Co‐Networks with Enhanced Cell Adhesion

Macromolecular Chemistry and Physics, Volume 227, Issue 5, 13 March 2026.
PCL‐PEG based ACN thin films provide a highly tunable biointerface, where PEG content governs morphology, protein adsorption, and cellular responses. PEG‐lean films support fibroblast adhesion and proliferation, while PEG‐rich films are non‐cell‐adhesive with low protein adsorption, reversible by dECM coating.
Yasmina El‐Faramawi, Kevin Hagmann, Stephanie Ihmann, Carolin Bunk, Andrea Cosimi, Carina Schneider, Frank Böhme, Regine von Klitzing, Marie Weinhart   +8 more
wiley   +1 more source

Aluminum versus Gallium: Differences in Bis(bis(trimethylsilyl)methyl) Element Halides, Hydrides, and Oxygen‐Bridged E/P Frustrated Lewis Pairs

ChemistryEurope, Volume 4, Issue 2, February 2026.
Reacting Bis2GaBr (Bis = CH(SiMe3)2) with Bis2AlH selectively yields Bis2GaH, a monomeric hydride in solution, characterized by diffusion ordered spectroscopy NMR, infrared spectroscopy and indirectly via hydrogallation. A one‐pot route enables frustrated Lewis pairs Bis2EOPtBu2 (E = Al, Ga), with the gallium analog splitting H2 and showing a dynamic ...
Julian Buth, Maximilian J. Klingsiek, Yury V. Vishnevskiy, Andreas Mix, Jan-Hendrik Lamm, Beate Neumann, Hans-Georg Stammler, Norbert Werner Mitzel   +7 more
wiley   +1 more source

Synthesis, Biological Activity, and Molecular Dynamics Simulations of LNA‐Charge Neutral Linkages for Enhanced Splice‐Switching Antisense Oligonucleotides

Angewandte Chemie, Volume 137, Issue 46, November 10, 2025.
Splice‐switching oligonucleotides are used to treat severe genetic conditions including Duchenne Muscular Dystrophy, but new chemistries are urgently required to improve their efficacy. In this work locked nucleic acid (LNA) is coupled to different charge neutral DNA backbones which are studied by structural, thermodynamic, and biological methods.
Alice Kennett, Lillian Lie, Martin Flerin, Belma Zengin Kurt, Ysobel R. Baker, Alyssa C. Hill, Abinaya Ramesh, Matthew J.A. Wood, Debashis Dhara, Afaf H. El‐Sagheer, Fernanda Duarte, Tom Brown   +11 more
wiley   +2 more sources

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, Volume 26, Issue 2-3, Page 33-80, February 2026.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source