Results 181 to 190 of about 52,246 (269)

A principal component entropy metric for assessing global synchronicity in EEG signals. [PDF]

open access: yesSci Rep
Diambra L   +5 more
europepmc   +1 more source

Cellular Heterogeneity in Drug Uptake Amplifies Pharmacodynamic Variability: A Stochastic PK‐PD Analysis

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 6, June 2026.
ABSTRACT Traditional pharmacokinetic‐pharmacodynamic models assume cellular homogeneity, yet clinical observations reveal substantial response variability even among patients with similar plasma exposure. We hypothesized that cellular heterogeneity in drug transporter expression, coupled with nonlinear dose–response relationships, can amplify ...
Nhung Hong‐Thi Duong   +4 more
wiley   +1 more source

The Power of Land: Structure and Function Transitions Steering China's Sustainable Development Goal Pathways

open access: yesEarth's Future, Volume 14, Issue 6, June 2026.
Abstract In the context of the 2030 Agenda for Sustainable Development Goal (SDG) entering its final critical window, it is essential that a more forward‐looking urban land‐management system be constructed, as land space constitute the core spatial carriers of the SDGs.
Guoen Wei   +14 more
wiley   +1 more source

An HHT–ANN Framework for Short‐Term Kp Forecasting

open access: yesSpace Weather, Volume 24, Issue 6, June 2026.
Abstract The geomagnetic activity index Kp is an important indicator of solar wind–magnetosphere coupling, and accurate 3‐hr‐ahead forecasting is important for space‐weather monitoring and warning. Because upstream solar wind and interplanetary magnetic field (IMF) signals are strongly nonlinear and nonstationary, methods based only on conventional ...
P. Yang   +5 more
wiley   +1 more source

Clearing the Air: How Fine Particulate Matter Regulations Reshape Farmland Values in U.S. Corn and Soybean Regions

open access: yesJournal of Agricultural Economics, Volume 77, Issue 2, Page 322-355, June 2026.
ABSTRACT We investigate the impact of air quality regulations targeting fine particulate matter (PM2.5) on farmland values in corn and soybean producing counties in the United States over the period 1997–2022. Using self‐reported farmland value data from the Agricultural Census and county‐level pollution classifications provided by the Environmental ...
Cécile Couharde, Rémi Generoso
wiley   +1 more source

Randomised, phase 1 evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of iptacopan in healthy volunteers

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 11, Page 2874-2889, June 2026.
Abstract Background and Purpose Overactivation of the alternative pathway (AP) underlies several diseases. Iptacopan is an oral, first‐in‐class, highly potent specific inhibitor of factor B, a key AP protease. Experimental Approach The analysis included data from two phase 1 randomised, volunteer‐blinded, placebo‐controlled studies: Study 1, a single ...
Irina Baltcheva   +5 more
wiley   +1 more source

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