Results 31 to 40 of about 226,273 (257)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

The Global Stratotype Section and Point (GSSP) for the base of the Holocene Series/Epoch (Quaternary System/Period) in the NGRIP ice core

, 2008
The Greenland ice core from NorthGRIP (NGRIP) contains a proxy climate record across the Pleistocene– Holocene boundary of unprecedented clarity and resolution.
Rasmussen, Sune Olander, Hoek, Wim Z., Steffensen, Jørgen Peder, Johnsen, Sigfus Johann, Steffensen, J. P., Rasmussen, Sune Ander, Steffensen, Jorgen-Peder, Schwander, Jakob, Andrews, John, Hoek, Wim, Walker, Mike, Gibbard, Philip, Hughen, Konrad, Walker, M., Litt, T., Kershaw, P., Johnsen, Sigfus, Kershaw, Peter, Popp, T., Steffensen, Jørgen-Peder, Hughen, K., Björck, Svante, Johnsen, Sigfu's, Lowe, J., Newnham, R., Kromer, Bernd, Nakagawa, Takeshi, Lowe, D. J., Popp, Trevor James, Lowe, J. John, Schwande, J., Cwynar, L., Newnham, Rewi, Newnham, Rewi M., Rasmussen, S. O., Popp, Trevor, Hoek, W., Cwynar, Les C., Lowe, David J., Nakagawa, T., Litt, Thomas, Lowe, John, Hughen, Konrad A., Kromer, B., Johnsen, S., Gibbard, P., Andrews, J., Cwynar, Les, Bjorck, S.   +48 more
core   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Timing and extent of Quaternary glaciations in the Tianger Range, eastern Tian Shan, China, investigated using Be-10 surface exposure dating

, 2014
Reconstructing glacial chronologies with consistent methods is critical for efforts to examine the timing and pattern of past climate change. Cosmogenic Be-10 surface exposure dating has been widely used to constrain the timing of glacial events on the ...
Caffee, Marc, Cui, Zhijiu, Harbor, Jon, Li, Yingkui, Stroeven, Arjen P., Li, Chuanchuan, Liu, Gengnian, Stroeven, Arjen P.,, Harbor, Jon,, Zhang, Mei, Chen, Yixin, Li, Yanan   +11 more
core   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Quaternary research in New Zealand since 2000: an overview

, 2012
With the AQUA milestone of 30 years it seems an appropriate time to review the progress and achievements of Quaternary research in New Zealand. This article highlights some of the major achievements since the formal review of New Zealand’s Quaternary ...
Lowe, David J., Bostock, Helen C., Newnham, Rewi M., Almond, Peter C.   +3 more
core  

Quaternary International [PDF]

, 2013
Texto completo. Acesso restrito. p. 85–90During the Quaternary in South America, the gomphotheres were one of the most common elements in the mammal megafauna. They went extinct in an evolutionary event known as the Late-Pleistocene Megafaunal Extinction,
Figueiredo, Ana Maria Graciano, Asevedo, Lidiane, Dominato, Victor Hugo, Avilla, Leonardo dos Santos, Mothé, Dimila, Baffa, Oswaldo, Kinoshita, Angela, Machado, Cristina Bertoni   +7 more
core  

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source