Results 81 to 90 of about 555,071 (331)

Hydroalkylation of Olefins To Form Quaternary Carbons.

Journal of the American Chemical Society, 2019
Metal-hydride hydrogen atom transfer (MHAT) functionalizes alkenes with predictable branched (Markovnikov) selectivity. The breadth of these transformations has been confined to π-radical traps; no sp3 electrophiles have been reported. Here we describe a
Samantha A. Green, Tucker R Huffman, Ruairi O. McCourt, Vincent van der Puyl, R. Shenvi   +4 more
semanticscholar   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Quaternary Stereocenters via an Enantioconvergent Catalytic SN1 Reaction

Nature, 2018
The unimolecular nucleophilic substitution (SN1) mechanism features prominently in every introductory organic chemistry course. In principle, stepwise displacement of a leaving group by a nucleophile via a carbocationic intermediate enables the ...
Alison E. Wendlandt, Prithvi Vangal, E. Jacobsen   +2 more
semanticscholar   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Range Mapper: An Adaptable Process for Making and Using Interactive, Animated Web Maps of Late-Quaternary Open Paleoecological Data

Open Quaternary, 2023
Here, we describe our process of developing Range Mapper, a new set of online interactive and animated visualizations of plant taxon range shifts since the Last Glacial Maximum. These animated maps of taxa distributions since the last deglaciation, based
Adrian K. George, Robert E. Roth, Sydney Widell, John W. Williams   +3 more
doaj   +1 more source

On Quaternary Gravels [PDF]

Quarterly Journal of the Geological Society of London
I n continuation of a paper on this subject in the Quart. Journ. Geol. Soc. vol. xxiv. p. 103, I now submit a number of measured sections selected as instances of the deposition of gravels of different character under different circumstances both of height above the sea-level and distance from the sea.
openaire   +2 more sources

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Reconstruction of the Last Glacial Snow Lines by the Evidences of Glacial Periods in North West Zagros (Case study: Anticline Qalajeh) [PDF]

جغرافیا و توسعه, 2015
Existence of  glacier and sub glacier landforms on Qalajeh mountains indicates the  climate changes and changes in morphogenic boundaries. The main problem of the research is identifying cold glacier and sub glacier territories and estimating  snow line ...
Aliakbar Shamsipour, Sajad Bagheri SeyedShokri, Maryam Jafari aghdam, Jabbar Salimimanesh   +3 more
doaj   +1 more source

Palladium-Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids to Five-, Six-, and Seven-Membered β-Substituted Cyclic Enones: Enantioselective Construction of All-Carbon Quaternary Stereocenters [PDF]

, 2011
The first enantioselective Pd-catalyzed construction of all-carbon quaternary stereocenters via 1,4-addition of arylboronic acids to β-substituted cyclic enones is reported. Reaction of a wide range of arylboronic acids and cyclic enones using a catalyst
Gatti, Michele, Holder, Jeffrey C., Kikushima, Kotaro, Stoltz, Brian M.   +3 more
core   +1 more source

Designing and Discovering a New Family of Semiconducting Quaternary Heusler Compounds Based on the 18-Electron Rule [PDF]

Chemistry of Materials, 2018
Intermetallic compounds with sizable band gaps are attractive for their unusual properties but rare. Here, we present a new family of stable semiconducting quaternary Heusler compounds, designed and discovered by means of high-throughput \textit{ab ...
Jiangang He, S. Naghavi, V. Hegde, M. Amsler, C. Wolverton   +4 more
semanticscholar   +1 more source