Tertiary alkylamines as nucleophiles in substitution reactions at heteroaromatic halide during the synthesis of the highly potent pirinixic acid derivative 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS-121) [PDF]
, 2011 YS-121 [2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid] is the result of target-oriented structural derivatization of pirinixic acid.
Gabler, Matthias +1 more
core +2 more sources
Photophysical and antibacterial activity of light-activated quaternary eosin Y
Open Chemistry, 2019 The functional characteristics of a new eosin dye with biocidal quaternary ammonium group (E) were studied in aqueous solution and in organic solvents of different polarity.
Staneva Desislava +4 more
doaj +1 more source
About sensititvity: salmonella biofi lms’ resistance to disinfectants action
Zaporožskij Medicinskij Žurnal, 2013 Salmonella biofi lms’ resistance to the action of the disinfectants was studied. It was founded that Salmonella biofi lms, which were formed on the hard carriers during 24 hours of incubation, demanded 32-fold increase of the minimal bactericide ...
V. F. Marievsky +2 more
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Novel Bis-Ammonium Salts of Pyridoxine: Synthesis and Antimicrobial Properties
Molecules, 2020 A series of 108 novel quaternary bis-ammonium pyridoxine derivatives carrying various substituents at the quaternary nitrogen’s and acetal carbon was synthesized.
Nikita V. Shtyrlin +16 more
doaj +1 more source
Crystals, 2019 The crystal structure of the iodide salt of a quaternary ammonium derivative of cholic acid having a naphthalene group attached to the 3rd position of the steroid nucleus through an amide bond ([3,5,7,12]-3-(2-naphthyloylamino)-7,12-dihydroxycholan-24 ...
Francisco Meijide +6 more
doaj +1 more source
Intracellular delivery of messenger RNA to macrophages with surfactant-derived lipid nanoparticles
Materials Today Advances, 2022 The broad biomedical applications of messenger RNA (mRNA)-based therapeutics rely heavily on the rapid development of mRNA delivery systems. In this study, dual-component lipid nanoparticles (LNPs) were developed for intracellular delivery of mRNA to ...
Y. Huang +7 more
doaj +1 more source
(E)-8-(4-(4-(Diphenylamino)styryl)phenoxy)-N,N,N-trimethyloctan-1-aminium Bromide
MolbankStructural optimization integrating triphenylamine and quaternary ammonium salt-based antimicrobial peptide mimics has yielded novel theranostic hybrid molecules.
Saiya Yang +7 more
doaj +1 more source
Process for purification of waste water produced by a Kraft process pulp and paper mill [PDF]
, 1979 The water from paper and pulp wastes obtained from a mill using the Kraft process is purified by precipitating lignins and lignin derivatives from the waste stream with quaternary ammonium compounds, removing other impurities by activated carbon produced
Humphrey, M. F.
core +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Quaternary Ammonium Compounds and Their Composites in Antimicrobial Applications
Advanced Materials InterfacesQuaternary ammonium compounds (QACs) are well‐known for their antimicrobial properties, but their widespread use is limited due to suboptimal antimicrobial efficiency and safety concerns.
Yining Yao +4 more
doaj +1 more source