Results 121 to 130 of about 61,390 (300)

The effectiveness of newly synthesized quaternary ammonium salts differing in chain length and type of counterion against priority human pathogens. [PDF]

Sci Rep, 2022
Kula N, Lamch Ł, Futoma-Kołoch B, Wilk KA, Obłąk E.   +4 more
europepmc   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Monoselective N-Methylation of Amides, Indoles, and Related Structures Using Quaternary Ammonium Salts as Solid Methylating Agents. [PDF]

Org Lett, 2022
Templ J, Gjata E, Getzner F, Schnürch M.   +3 more
europepmc   +1 more source

A case study showing the role of hydrophobicity variants and other enriched mAb proteoforms on filterability through a virus filter with productivity improvement measures

Biotechnology Progress, EarlyView.
Abstract A rapid assessment of manufacturability for drug candidates is crucial for advancing a prospective biotherapeutic from a candidate to a bulk drug substance. A lot‐to‐lot approach to manufacturability is adopted where each biologic batch is assessed for manufacturability as a bulk, unfractionated pool.
Solomon Isu, Derek Silva, Melissa Holstein, Angela Lewandowski, Kristina Cunningham, Adam Sokolnicki, Bala Raghunath   +6 more
wiley   +1 more source

Effect of Quaternary Ammonium Salts and 1,2,4-Triazole Derivatives on Hydrogen Absorption by Mild Steel in Hydrochloric Acid Solution. [PDF]

Materials (Basel), 2022
Avdeev YG, Nenasheva TA, Luchkin AY, Marshakov AI, Kuznetsov YI.   +4 more
europepmc   +1 more source

Synthesis and Characterization of π‐Extended Azulenes via Nucleophilic Substitution and Intramolecular Cyclization of 5‐Alkynyl‐6‐Fluoroazulenes

ChemistryEurope, EarlyView.
A modular synthetic approach enables the preparation of azulene‐fused heterocycles via nucleophilic aromatic substitution followed by intramolecular cyclization of alkynyl fluoroazulenes. The method allows the incorporation of various heteroatoms (N, O, S, Se, and Te), leading to structurally diverse heteroannulated azulenes.
Martin C. Dietl, Matthias Scherr, Christopher Hüßler, Henrik T. Habeck, Carmen L. M. Henel, Jürgen Graf, Frank Rominger, Matthias Rudolph, A. Stephen K. Hashmi   +8 more
wiley   +1 more source

Selective α-Methylation of Aryl Ketones Using Quaternary Ammonium Salts as Solid Methylating Agents. [PDF]

J Org Chem, 2022
Templ J, Schnürch M.
europepmc   +1 more source

Polydopamine‐Mediated Grafting of Cationic Polymer Brushes for Adsorption of Fluorinated Compounds

Chemistry – A European Journal, EarlyView.
We introduce a versatile approach to fabricate tunable charged interfaces by functionalizing stonewool fibers with a polydopamine (PDA)–quaternary amine coating via a grafting‐to method. The modified surfaces exhibit rapid, concentration‐dependent adsorption of anionic species driven by electrostatic interactions.
Agnes C. Morrissey, Federica Sbordone, Fred Pashley‐Johnson, Aaron S. Micallef, Bart van de Worp, Neomy Zaquen, Prasanna Egodawatta, Laura Delafresnaye, Lukas Michalek, Christopher Barner‐Kowollik   +9 more
wiley   +1 more source

Copper‐ and Silver‐Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five‐ and Six‐Membered Heterocycles

Chemistry – A European Journal, EarlyView.
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley   +1 more source

Sustainable triazine-derived quaternary ammonium salts as antimicrobial agents. [PDF]

RSC Adv, 2021
Morandini A, Spadati E, Leonetti B, Sole R, Gatto V, Rizzolio F, Beghetto V.   +6 more
europepmc   +1 more source