Results 231 to 240 of about 44,905 (302)

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

open access: yesThe FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti   +11 more
wiley   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

open access: yesThe FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu   +2 more
wiley   +1 more source

Cosmetic creams with caprylic acid‐based Natural Eutectic Solvents: Stability, rheology and user perception

open access: yesInternational Journal of Cosmetic Science, EarlyView.
By formulating creams with caprylic acid‐based hydrophobic Natural Eutectic Solvents and assessing their stability, rheological behaviour and sensory properties, this study demonstrates how these systems can act as multifunctional, COSMOS‐compliant ingredients that modulate emulsion characteristics without compromising formulation properties.
Alexis Verger   +7 more
wiley   +1 more source

NPF2 is involved in intracellular pH regulation and ion balance in the diatom Phaeodactylum tricornutum

open access: yesNew Phytologist, EarlyView.
Summary Cellular ion and pH homeostasis are crucial factors affecting and regulating metabolic reactions, protein stability, signalling and transport mechanisms. To balance intracellular ion concentrations, organisms need to constantly sense and respond to both the extracellular environment and cell compartments' requests.
Anna Santin   +15 more
wiley   +1 more source

Rhamnogalacturonan‐II Dimerisation Reinforces Salt Resistance in Sugar Beet

open access: yesPlant, Cell &Environment, EarlyView.
ABSTRACT Salinity stress predominantly affects negatively charged cell wall polymers, for example, pectin. Excess Na+ ions interact physically and affect growth in stress‐sensitive plants. However, the salinity resistance of sugar beet cell walls remains unclear.
Shah Newaz Chowdhury   +5 more
wiley   +1 more source

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