Results 131 to 140 of about 13,019 (252)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Quaternion Colour Texture

open access: yes, 2008
Quaternion colour processing; quaternion principal component analysis, colour texture; image segmentation; colour texture classification The quaternion representation of colour is shown to be effective in the context of colour texture region segmentation
Brian Funt, Lilong Shi
core  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Fading-Memory Quaternion-Based Kalman Filter for Quantum Channel PMD Compensation

open access: yesIEEE Access
Polarization mode dispersion in optical fibers corrupts polarization-encoded quantum states through random, time- and frequency-varying rotations. Because quantum states cannot be directly measured and reused without disturbance, practical mitigation ...
Omar Alnaseri   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Weighted Convolution for Quaternion Linear Canonical Cosine Transform and Its Application

open access: yesAxioms
Convolution plays a pivotal role in the domains of signal processing and optics. This paper primarily focuses on studying the weighted convolution for quaternion linear canonical cosine transform (QLCcT) and its application in multiplicative filter ...
Rongbo Wang, Qiang Feng
doaj   +1 more source

“Balbin's Quaternions” [PDF]

open access: yesNature, 1888
NATURE of December 15, 1887 (p. 145), which has lately reached me, contains a notice of a treatise on Quaternions, by Prof. Valentin Balbin, in which the reviewer alludes to the “slight alterations” introduced into the notation of quaternions by Messrs. Houel and Laisant, and apparently visits them all with equal condemnation.
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Augmented Quaternion and Augmented Unit Quaternion Optimization

open access: yes, 2023
In this paper, we introduce and explore augmented quaternions and augmented unit quaternions, and present an augmented unit quaternion optimization model. An augmented quaternion consist of a quaternion and a translation vector.
Wang, Xiangke, Cui, Chunfeng, Qi, Liqun
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

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