Results 71 to 80 of about 635,069 (331)
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
LeadOp+R: Structure-Based Lead Optimization With Synthetic Accessibility
Frontiers in Pharmacology, 2018 We previously described a structure-based fragment hopping for lead optimization using a pre-docked fragment database, “LeadOp,” that conceptually replaced “bad” fragments of a ligand with “good” fragments while leaving the core of the ligand intact thus
Fang-Yu Lin +3 more
doaj +1 more source
FEBS Letters, EarlyView.Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt +4 more
wiley +1 more source
The Use of QBIC Content-Based Image Retrieval System [PDF]
Journal of Library and Information Studies, 2004 The fast increase in digital images has caught increasing attention on the development of image retrieval technologies. Content-based image retrieval (CBIR) has become an important approach in retrieving image data from a large collection.
Ching-Yi Wu +2 more
doaj
Introducing new constructs for data modelling and column generation in LP modelling languages [PDF]
, 1993 Through popular implementation of structured query language (SQL) and query-by-example(QBE) relational databases have become the de-facto industry standard for data modelling.We consider the indices, sets, and the declarative form of Linear Programming ...
Kristjansson, B +3 more
core
Active classification with comparison queries
, 2017 We study an extension of active learning in which the learning algorithm may ask the annotator to compare the distances of two examples from the boundary of their label-class. For example, in a recommendation system application (say for restaurants), the
Kane, Daniel M. +3 more
core +1 more source
FEBS Letters, EarlyView.Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel +2 more
wiley +1 more source
A Hybrid Query Scheme to Speed Up Queries in Unstructured Peer-to-Peer Networks
Advances in Multimedia, 2007 Unstructured peer-to-peer networks have gained a lot of popularity due to their resilience to network dynamics. The core operation in such networks is to efficiently locate resources.
Zhan Zhang +3 more
doaj +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
IEEE AccessQuery-by-example spoken term detection (QbE-STD) refers to the search for an audio query in a repository of audio utterances. A common approach for QbE-STD involves computing a matching matrix between the feature representations of the query and the ...
Manisha Naik Gaonkar +3 more
doaj +1 more source