Results 101 to 110 of about 3,764,864 (296)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

open access: yesFEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Code Generation for Efficient Query Processing in Managed Runtimes [PDF]

open access: yes, 2014
In this paper we examine opportunities arising from the convergence of two trends in data management: in-memory database systems (IMDBs), which have received renewed attention following the availability of affordable, very large main memory systems; and ...
Nagel, Fabian   +5 more
core  

Query languages for neural networks

open access: yesCoRR
We lay the foundations for a database-inspired approach to interpreting and understanding neural network models by querying them using declarative languages. Towards this end we study different query languages, based on first-order logic, that mainly differ in their access to the neural network model. First-order logic over the reals naturally yields a
Martin Grohe   +3 more
openaire   +5 more sources

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

Document expansion, query translation and language modeling for ad-hoc IR [PDF]

open access: yes, 2010
For the multilingual ad-hoc document retrieval track (TEL) at CLEF, Trinity College Dublin and Dublin City University participated in collaboration. Our retrieval experiments focused on i) document expansion using an entry vocabulary module, ii) query ...
Wade, Vincent   +7 more
core   +2 more sources

Naturally embedded query languages

open access: yes, 1992
We investigate the properties of a simple programming language whose main computational engine is structural recursion on sets. We describe a progression of sublanguages in this paradigm that (1) have increasing expressive power, and (2) illustrate robust conceptual restrictions thus exhibiting interesting additional properties.
Tannen, Val   +2 more
openaire   +5 more sources

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

open access: yesFEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata   +3 more
wiley   +1 more source

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