Results 51 to 60 of about 439,560 (345)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Default logic as a query language

open access: yesIEEE Transactions on Knowledge and Data Engineering, 1994
Research in nonmonotonic reasoning has focused largely on the idea of representing knowledge about the world via rules that are generally true but can be defeated. Even if relational databases are nowadays the main tool for storing very large sets of data, the approach of using nonmonotonic AI formalisms as relational database query languages has been ...
CADOLI, Marco   +2 more
openaire   +6 more sources

Intuitive querying of e-Health data repositories [PDF]

open access: yes, 2005
At the centre of the Clinical e-Science Framework (CLEF) project is a repository of well organised, detailed clinical histories, encoded as data that will be available for use in clinical care and in-silico medical experiments.
Hallett, Catalina   +2 more
core   +2 more sources

Sculpting Quantum Speedups [PDF]

open access: yes, 2015
Given a problem which is intractable for both quantum and classical algorithms, can we find a sub-problem for which quantum algorithms provide an exponential advantage?
Aaronson, Scott, Ben-David, Shalev
core   +2 more sources

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

LinkedImm: a linked data graph database for integrating immunological data

open access: yesBMC Bioinformatics, 2021
Background Many systems biology studies leverage the integration of multiple data types (across different data sources) to offer a more comprehensive view of the biological system being studied. While SQL (Structured Query Language) databases are popular
Syed Ahmad Chan Bukhari   +4 more
doaj   +1 more source

Improved Centralized XML Query Processing Using Distributed Query Workload

open access: yesIEEE Access, 2021
eXtensible Markup Language (XML) is used widely to transfer data among a wide variety of systems. Due to an increase in query workloads and management of larger datasets, centralized processing is no longer feasible for XML query processing.
Samini Subramaniam   +2 more
doaj   +1 more source

The network query language NOAH

open access: yesProceedings of the 1982 ACM SIGMOD international conference on Management of data - SIGMOD '82, 1982
A non-procedural query language for network databases is described. The language is very powerful as compared to other implemented languages. It allows to formulate complex queries which, among other things, include conditions for CODASYL-sets and conditions for n:m-relationships.
Rieskamp, Michael   +3 more
openaire   +2 more sources

Ontology-based data access with databases: a short course [PDF]

open access: yes, 2013
Ontology-based data access (OBDA) is regarded as a key ingredient of the new generation of information systems. In the OBDA paradigm, an ontology defines a high-level global schema of (already existing) data sources and provides a vocabulary for user ...
A. Artale   +23 more
core   +3 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

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