Results 171 to 180 of about 482,214 (330)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Efficient skyline query processing with user-specified conditional preference. [PDF]

PeerJ Comput Sci
Ke S, Fu X, Li J.
europepmc   +1 more source

SparkGIS: Resource Aware Efficient In-Memory Spatial Query Processing. [PDF]

Proc ACM SIGSPATIAL Int Conf Adv Inf, 2017
Baig F, Vo H, Kurc T, Saltz J, Wang F.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

<i>F</i>u<i>n</i>Da: scalable serverless data analytics and in situ query processing. [PDF]

J Big Data
Lounissi E, Das SK, Peter R, Zhang X, Ray S, Jia L.   +5 more
europepmc   +1 more source

Private and Efficient Query Processing on Outsourced Genomic Databases. [PDF]

IEEE J Biomed Health Inform, 2017
Ghasemi R, Al Aziz MM, Mohammed N, Dehkordi MH, Jiang X.   +4 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

CSQUiD: an index and non-probability framework for constrained skyline query processing over uncertain data. [PDF]

PeerJ Comput Sci
Lawal MM, Ibrahim H, Mohd Sani NF, Yaakob R, Alwan AA.   +4 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

BioFed: federated query processing over life sciences linked open data. [PDF]

J Biomed Semantics, 2017
Hasnain A, Mehmood Q, Sana E Zainab S, Saleem M, Warren C, Zehra D, Decker S, Rebholz-Schuhmann D.   +7 more
europepmc   +1 more source