Results 41 to 50 of about 102,125 (260)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Intelligent Collaborative Event Query Algorithm in Wireless Sensor Networks

open access: yesInternational Journal of Distributed Sensor Networks, 2011
Event query processing is a very important issue in wireless sensor networks (WSNs). In order to detect event early and provide monitoring information and event query timely in WSNs, an efficient intelligent collaborative event query (ICEQ) algorithm is ...
Rongbo Zhu
doaj   +1 more source

Quadrant-Based Minimum Bounding Rectangle-Tree Indexing Method for Similarity Queries over Big Spatial Data in HBase

open access: yesSensors, 2018
With the rapid development of mobile devices and sensors, effective searching methods for big spatial data have recently received a significant amount of attention.
Bumjoon Jo, Sungwon Jung
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

k Nearest Neighbor Search for Location-Dependent Sensor Data in MANETs

open access: yesIEEE Access, 2015
K nearest neighbor (kNN) queries, which retrieve the k nearest sensor data items associated with a location (location-dependent sensor data) from the location of the query issuer, are useful for location-based services in mobile environments.
Yuka Komai   +3 more
doaj   +1 more source

Complex Spatial Query Processing [PDF]

open access: yesGeoInformatica, 2004
The user of a Geographical Information System is not limited to conventional spatial selections and joins, but may also pose more complicated and descriptive queries. In this paper, we focus on the efficient processing and optimization of complex spatial queries that involve combinations of spatial selections and joins. Our contribution is manifold; we
Mamoulis, N, Papadias, D, Arkoumanis, D
openaire   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

CBSL - A Compressed Binary String Labeling Scheme for Dynamic Update of XML documents

open access: yesJournal of Computing and Information Technology, 2018
The growing volume of XML documents over the Web has increased the need for an efficient mechanism to facilitate query processing. Many labeling schemes have been introduced to optimize data retrieval and query processing on XML database documents. As it
Dhanalekshmi Gopinathan, Krishna Asawa
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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