Results 101 to 110 of about 3,002,497 (295)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Prompting Large Language Models with Knowledge-Injection for Knowledge-Based Visual Question Answering

Big Data Mining and Analytics
Previous works employ the Large Language Model (LLM) like GPT-3 for knowledge-based Visual Question Answering (VQA). We argue that the inferential capacity of LLM can be enhanced through knowledge injection. Although methods that utilize knowledge graphs
Zhongjian Hu, Peng Yang, Fengyuan Liu, Yuan Meng, Xingyu Liu   +4 more
doaj   +1 more source

Data and Knowledge Enhanced Medical Visual Question Answer Network [PDF]

Jisuanji kexue
Med-VQA aims to accurately answer clinical questions based on a given medical image,which is key in advancing clinical medical intelligence.Despite some progress in this field,challenges remain in extracting deep multimodal information from both images ...
YAN Yujing, HOU Xia, GUO Yuting, ZHANG Mingliang, SONG Wenfeng
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Knowledge injection methods in question answering

Российский технологический журнал
Objectives. Despite the recent success of large language models, which are now capable of solving a wide range of tasks, a number of practical issues remain unsolved. For example, users of systems providing question answering (QA) services may experience
D. V. Radyush
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Visual question answering for medical diagnosis

Intelligent Systems with Applications
The use of Artificial Intelligence (AI) in medical diagnosis is a breakthrough in healthcare, improving both accuracy and efficiency. Recently, a significant advancement has been made toward the development of multimodal AI systems that can process and ...
Nawel Ben Chaabane, Mohamed Bal-Ghaoui
doaj   +1 more source