Results 101 to 110 of about 168,099 (309)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Research on intelligent government question answering system with autonomous learning and memory function

Dianzi Jishu Yingyong
Once a task-based question answering system is built, it is usually fixed and can answer very limited questions, making it difficult to meet user needs. A method for automatically updating the knowledge base in real-time was proposed.
Fang Haiquan, Deng Mingming
doaj   +1 more source

Coreference-Based Summarization and Question Answering: a Case for High Precision Anaphor Resolution

, 2005
Approaches to Text Summarization and Question Answering are known to benefit from the availability of coreference information. Based on an analysis of its contributions, a more detailed look at coreference processing for these applications will be ...
Stuckardt, Roland
core  

Question-answering through selecting and connecting peer-students [PDF]

, 2007
Van Rosmalen, P., Brouns, F., Sloep, P., Kester, L., Berlanga, A., Bitter, M., & Koper, R. (2007). Question-answering through selecting and connecting peer-students. Presentation at the ePortfolio Conference.
Brouns, Francis, Kester, Liesbeth, Sloep, Peter, Koper, Rob, Van Rosmalen, Peter, Brouns, Francis; id_orcid, Berlanga, Adriana, Bitter-Rijpkema, Marlies   +7 more
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Data and Knowledge Enhanced Medical Visual Question Answer Network [PDF]

Jisuanji kexue
Med-VQA aims to accurately answer clinical questions based on a given medical image,which is key in advancing clinical medical intelligence.Despite some progress in this field,challenges remain in extracting deep multimodal information from both images ...
YAN Yujing, HOU Xia, GUO Yuting, ZHANG Mingliang, SONG Wenfeng
doaj   +1 more source

Cross-lingual Question Answering with QED [PDF]

, 2004
We present improvements and modifications of the QED open-domain question answering system developed for TREC-2003 to make it cross-lingual for participation in the CrossLinguistic Evaluation Forum (CLEF) Question Answering Track 2004 for the source ...
Johan Bos, Tiphaine Dalmas, Bos, Johan, Smillie, Matthew B., Jochen L. Leidner, Leidner, Jochen L., Matthew B. Smillie, Beatrice Alex, Kisuh Ahn, Dalmas, Tiphaine, Ahn, Kisuh, Alex, Beatrice   +11 more
core  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Prompting Large Language Models with Knowledge-Injection for Knowledge-Based Visual Question Answering

Big Data Mining and Analytics
Previous works employ the Large Language Model (LLM) like GPT-3 for knowledge-based Visual Question Answering (VQA). We argue that the inferential capacity of LLM can be enhanced through knowledge injection. Although methods that utilize knowledge graphs
Zhongjian Hu, Peng Yang, Fengyuan Liu, Yuan Meng, Xingyu Liu   +4 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source