Results 121 to 130 of about 3,002,497 (295)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Generative Models for Multiple-Choice Question Answering in Portuguese: A Monolingual and Multilingual Experimental Study

Proceedings of the International Florida Artificial Intelligence Research Society Conference
Multiple-choice questions are commonly used to assess knowledge through a set of possible answers to a given question. Determining the correct answer relies on the balance between understanding the question’s content and the associated logic. Generative
Guilherme Dallmann Lima, Emerson Lopes, Henry Pereira, Marilia Silveira, Larissa Freitas, Ulisses Corrêa   +5 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Question-answering through selecting and connecting peer-students [PDF]

, 2007
Van Rosmalen, P., Brouns, F., Sloep, P., Kester, L., Berlanga, A., Bitter, M., & Koper, R. (2007). Question-answering through selecting and connecting peer-students. Presentation at the ePortfolio Conference.
Brouns, Francis, Kester, Liesbeth, Sloep, Peter, Koper, Rob, Van Rosmalen, Peter, Brouns, Francis; id_orcid, Berlanga, Adriana, Bitter-Rijpkema, Marlies   +7 more
core   +1 more source

Research on the construction and application of retrieval enhanced generation (RAG) model based on knowledge graph

Scientific Reports
Generative pre-trained language models have demonstrated strong capabilities in natural language processing tasks, but they still suffer from “fact hallucination” and weak knowledge timeliness in open-domain question answering and text generation.
Sili Wang, Heng Yang, Wei Liu
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

QARR-FSQA: Question-Answer Replacement and Removal Pretraining Framework for Few-Shot Question Answering

IEEE Access
In Natural Language Processing, creating training data for question answering (QA) systems typically requires significant effort and expertise. This challenge is amplified in few-shot scenarios where only a limited number of training samples are ...
Siao Wah Tan, Chin Poo Lee, Kian Ming Lim, Connie Tee, Ali Alqahtani   +4 more
doaj   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Cross-lingual Question Answering with QED [PDF]

, 2004
We present improvements and modifications of the QED open-domain question answering system developed for TREC-2003 to make it cross-lingual for participation in the CrossLinguistic Evaluation Forum (CLEF) Question Answering Track 2004 for the source ...
Johan Bos, Tiphaine Dalmas, Bos, Johan, Smillie, Matthew B., Jochen L. Leidner, Leidner, Jochen L., Matthew B. Smillie, Beatrice Alex, Kisuh Ahn, Dalmas, Tiphaine, Ahn, Kisuh, Alex, Beatrice   +11 more
core  

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source