Results 81 to 90 of about 2,913,582 (292)

Regulatory harmonization: Evolution, globalization and future directions

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm   +2 more
wiley   +1 more source

Known-Item Retrieval Performance of a PICO-based Medical Question Answering Engine

open access: yesAsia Pacific Journal of Information Systems, 2015
The performance of a novel medical question-answering engine called CliniCluster and existing search engines, such as CQA-1.0, Google, and Google Scholar, was evaluated using known-item searching. Known-item searching is a document that has been critically appraised to be highly relevant to a therapy question.
Vong, Wan-Tze, Then, Patrick Hang Hui
openaire   +2 more sources

Current practice and guideline adherence in renal dose adjustment for patients with chronic kidney disease: A systematic review and meta‐analysis

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed   +7 more
wiley   +1 more source

Long‐term cost‐effectiveness of belatacept vs. tacrolimus in kidney transplantation: Trade‐off between metabolic benefit and immunological risk

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the long‐term cost‐effectiveness of belatacept vs. tacrolimus as maintenance immunosuppression in adult kidney transplant recipients, focusing on the trade‐off between reduced new‐onset diabetes after transplantation (NODAT), immunological risk and potential renal benefit.
Salvatore Di Maria   +2 more
wiley   +1 more source

In canine cranial cruciate ligament rupture is outcome following TPLO improved compared with lateral suture?

open access: yesVeterinary Evidence, 2019
PICO question In dogs over 15 kg, with cranial cruciate ligament rupture is there evidence of improved outcome following tibial plateau levelling osteotomy or lateral fabellotibial suture?
Catrina Pennington   +2 more
doaj   +1 more source

[EBM: otitis media in children: how to formulate a PICO question].

open access: yesRevue medicale de Liege, 2005
This series of articles begins with a problem frequently encountered in children: acute otitis media. Under the insistence of parents, antibiotics are frequently prescribed. The physician knows that the value of that therapy is debatable, but what for a child of 6 years of age?
Van den Bruel, A   +4 more
openaire   +2 more sources

“We need to talk about PICO”: Approaching the move from question formulation to search strategy

open access: yesJournal of Health Information and Libraries Australasia, 2023
This paper begins with PICO and its place in health librarianship, before moving to discuss a model of teaching knowledge that may offer some new ways of thinking about PICO (or, perhaps, leaving PICO behind). My two main points of contention with the ubiquity of PICO in health librarianship are:  That it is only one among many approaches to ...
openaire   +1 more source

Avances de la AER General Pico 2023-2024

open access: yes
Esta publicación cuenta con trabajos desarrollados por los profesionales y personal de apoyo técnico de la Agencia de Extensión Rural de General Pico del INTA durante el período 2023 / 2024.
Ghironi, Eugenia Margarita (compiladora)   +1 more
core   +1 more source

Does Grain Actually Predispose Our Cats to Gain Weight?

open access: yesVeterinary Evidence, 2019
PICO questionIn adult cats, does feeding grain free maintenance diet reduce the risk of obesity compared to feeding a maintenance diet containing grains?Clinical bottom lineThere is no evidence showing feeding grain free maintenance diet reduces the risk
Yaiza Gomez-Mejias
doaj   +1 more source

What drives animal responses to high severity fire? The role of functional traits

open access: yesBiological Reviews, EarlyView.
ABSTRACT Fire regimes are changing worldwide, with increases in the frequency, extent, and severity of fires posing growing risks to biodiversity. Fire severity – the degree of habitat alteration following fire – strongly influences both immediate survival and long‐term recovery of fauna.
Grace A. Vielleux   +3 more
wiley   +1 more source

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