Results 61 to 70 of about 4,505,795 (313)

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Topics in Present-day Science Technology and Innovation: Ultrafast Relaxation Processes in Semiconductors [PDF]

Materials Research, 2015
The nowadays notable development of all the modern technology, fundamental for the progress and well being of world society, imposes a great deal of stress in the realm of basic Physics, more precisely on Thermo-Mechanical Statistics.
Clóves Gonçalves Rodrigues, Áurea Rosas Vasconcellos, Roberto Luzzi   +2 more
doaj   +2 more sources

Using PICO Methodology to Answer Questions About Smoking in COPD Patients

Archivos de Bronconeumología (English Edition), 2017
The ALAT and SEPAR Treatment and Control of Smoking Groups have collaborated in the preparation of this document which attempts to answer, by way of PICO methodology, different questions on health interventions for helping COPD patients to stop smoking.
Jiménez Ruiz C.A., Buljubasich D., Riesco Miranda J.A., Acuña Izcaray A., de Granda Orive J.I., Chatkin J.M., Zabert G., Guerreros Benavides A., Paez Espinel N., Noé V., Sánchez-Angarita E., Núñez-Sánchez I., Sansores R.H., Casas A., Palomar Lever A., Alfageme Michavila I.   +15 more
openaire   +2 more sources

Appearance of Population, Intervention, Comparison, and Outcome as research question in the title of articles of three different anesthesia journals: A pilot study

Saudi Journal of Anaesthesia, 2018
Background: It is well known in the evidence-based medicine practice that framing the research question is the most important and crucial part of the research integrity.
A. Eldawlatly, H. Alshehri, Abdulla Z. AlQahtani, A. Ahmad, Fatma K Al-Dammas, A. Marzouk   +5 more
semanticscholar   +1 more source

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

An Integrated Practical Evidence-Based Medicine Curriculum: Two Small-Group Sessions to Teach PICO Question Formation and Searching Strategies

MedEdPORTAL, 2013
Introduction The need to teach evidence-based medicine (EBM) goes beyond meeting the requirements of residency. For residents and all practicing physicians, there must be a process to ensure that doctors know the latest and best information to apply to ...
Rachel Boykan, Maribeth Chitkara, Colleen Kenefick, Catherine Messina   +3 more
doaj   +1 more source

Are geographical indications a way to "decommodify" the coffee market? [PDF]

, 2008
The commodity nature of green coffee is the main cause of "the coffee paradox" (decreasing prices at production level and rising prices at consumption level).
Belletti, Giovanni, Galtier, Franck, Marescotti, Andrea   +2 more
core  

Connection between slow and fast dynamics of molecular liquids around the glass transition [PDF]

, 2010
The mean-square displacement (MSD) was measured by neutron scattering at various temperatures and pressures for a number of molecular glass-forming liquids.
Alba-Simionesco, C., Dalle-Ferrier, C., Dyre, J., Frick, B., Niss, K., Russo, D.   +5 more
core   +3 more sources

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source