Results 61 to 70 of about 2,913,582 (292)

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

open access: yesAdvanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma   +12 more
wiley   +1 more source

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

open access: yesAdvanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang   +18 more
wiley   +1 more source

Ether‐Based Electrolytes and the Solvation Structure in Sodium Ion Batteries

open access: yesAdvanced Energy Materials, EarlyView.
Ether electrolytes enable high‐performance sodium‐ion batteries through their unique physicochemical properties, particularly distinctive solvation structures and co‐intercalation behavior. However, the localized solvation structure and its dynamic evolution during electrochemical processes remain a “black box”.
Jiaxin Ding, John T. S. Irvine
wiley   +1 more source

Assessing Government Subsidies for Reducing Pesticide Use: A Meta‐Analysis

open access: yesApplied Economic Perspectives and Policy, EarlyView.
ABSTRACT In the efforts being made by governments to reduce pesticide use, subsidies are an important instrument to encourage farmers to adopt more sustainable practices. Yet, their effectiveness remains uncertain due to diverse designs and contexts.
Gaëlle Leduc   +3 more
wiley   +1 more source

The therapeutic effectiveness of oral cannabidiol in addition to current treatment in cats with osteoarthritis

open access: yesVeterinary Evidence
Question In cats with osteoarthritis (OA), does the oral supplementation of cannabidiol (CBD) oil, compared to conventional treatment alone, improve treatment outcomes of reducing pain and improving locomotion?   Clinical bottom line The category
Oliver Wilkinson
doaj   +1 more source

Beyond Behaviour: Exploring How Positive Behaviour Support Might Work for Autistic Children Within Australia's NDIS

open access: yesAustralian Journal of Social Issues, EarlyView.
ABSTRACT Positive Behaviour Support (PBS) is the National Disability Insurance Scheme (NDIS) endorsed‐behavioural intervention framework. Understanding how and why PBS is effective is critical, given the increasing number of autistic children accessing the NDIS.
Cameron Stott   +4 more
wiley   +1 more source

Pico-photonics: Anomalous Atomistic Waves in Silicon

open access: yes, 2022
The concept of photonic frequency $(\omega)$ - momentum $(q)$ dispersion has been extensively studied in artificial dielectric structures such as photonic crystals and metamaterials. However, the $\omega-q$ dispersion of electrodynamic excitations hosted
Sathwik Bharadwaj (14380245)   +2 more
core   +1 more source

Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome

open access: yesAnnals of Neurology, EarlyView.
Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca   +24 more
wiley   +1 more source

Cats that get stressed when visiting the veterinary practice: can gabapentin help improve their welfare?

open access: yesVeterinary Evidence, 2019
PICO question In cats which are stressed as a consequence of veterinary interventions does gabapentin administration, compared with no gabapentin, result in lower levels of stress?
Louise Anne Buckley
doaj   +1 more source

Search question in terms of PICO (Population, intervention, comparison, and outcome).

open access: yes, 2023
Search question in terms of PICO (Population, intervention, comparison, and outcome).
Ilmari Larivuo (14691726)   +4 more
core   +1 more source

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