Results 41 to 50 of about 2,913,582 (292)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Managing atopic dermatitis in dogs: are antihistamines as effective as glucocorticoids?
Veterinary Evidence, 2020 PICO question In dogs with atopic dermatitis, are antihistamines as effective as glucocorticoids at reducing the severity of clinical signs? Clinical bottom line Category of research question Treatment The number and type of study ...
Sarah Long
doaj +1 more source
Can straw based enrichment treat tail biting in pigs?
Veterinary Evidence, 2022 PICO question Can straw based enrichment be used successfully as a treatment intervention to reduce tail biting injuries in weaner to finisher pigs housed in indoor farming systems?
Abigail Liston
doaj +1 more source
Integrating the Framing of Clinical Questions via PICO into the Retrieval of Medical Literature for Systematic Reviews [PDF]
Proceedings of the 2017 ACM on Conference on Information and Knowledge Management, 2017 The PICO process is a technique used in evidence based practice to frame and answer clinical questions. It involves structuring the question around four types of clinical information: Population, Intervention, Control or comparison and Outcome. The PICO framework is used extensively in the compilation of systematic reviews as the means of framing ...
Harrisen Scells +5 more
openaire +4 more sources
Seismic vulnerability of churches in Faial and Pico islands, Azores [PDF]
, 2012 Earthquakes represent one of the main cause of serious damage and loss of historic and architectural heritage. Interventions to preserve these building should start with a careful knowledge and assessment of their seismic vulnerability, in order to ...
Costa, A. +6 more
core
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Veterinary Evidence, 2016 Clinical bottom lineBased on the lack of sufficient clinical studies investigating the PICO question, it is not possible to conclude if physical therapy should be recommended as a routine postoperative treatment after TPLO.
Andrea Faure Beaulieu, Antonio Pozzi
doaj +1 more source
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Vers un système peer-to-peer d’aide à la décision en périodes d’épidémies. COVID-19 comme exemple.
Revue Nature et Technologie, 2022 Lors d’une épidémie/pandémie causée par un virus inconnu comme le SRAS-CoV-2, agent responsable du COVID-19, les praticiens de la santé ne peuvent pas prédire le comportement du virus et donc l’évolution de la maladie.
Badr MERAD +2 more
doaj +6 more sources
Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine
Advanced Healthcare Materials, EarlyView.Multistimuli responsive dynamic covalent materials integrate reversible chemistry with the complex chemical, mechanical, and biochemical cues of regenerative environments. This review highlights chemical strategies based on orthogonal dynamic bonds, multicomponent networks, and hierarchical architectures to regulate mechanics, degradation, and ...
Saurabh Joshi +2 more
wiley +1 more source