Results 41 to 50 of about 35,679 (292)
Veterinary Evidence, 2023 PICO Question In dogs with chronic enteropathy (idiopathic inflammatory bowel disease) is budesonide more effective than prednisolone or prednisone in resolving clinical signs or improving the canine inflammatory bowel disease (IBD) activity index ...
Victoria Alice Coates
doaj +1 more source
Preclinical risk of bias assessment and PICO extraction using natural language processing [PDF]
, 2022 Drug development starts with preclinical studies which test the efficacy and toxicology of potential candidates in living animals, before proceeding to clinical trials examined on human subjects.
Wang, Qianying
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Vers un système peer-to-peer d’aide à la décision en périodes d’épidémies. COVID-19 comme exemple.
Revue Nature et Technologie, 2022 Lors d’une épidémie/pandémie causée par un virus inconnu comme le SRAS-CoV-2, agent responsable du COVID-19, les praticiens de la santé ne peuvent pas prédire le comportement du virus et donc l’évolution de la maladie.
Badr MERAD +2 more
doaj +6 more sources
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Veterinary Evidence, 2016 Clinical bottom lineBased on the lack of sufficient clinical studies investigating the PICO question, it is not possible to conclude if physical therapy should be recommended as a routine postoperative treatment after TPLO.
Andrea Faure Beaulieu, Antonio Pozzi
doaj +1 more source
Managing atopic dermatitis in dogs: are antihistamines as effective as glucocorticoids?
Veterinary Evidence, 2020 PICO question In dogs with atopic dermatitis, are antihistamines as effective as glucocorticoids at reducing the severity of clinical signs? Clinical bottom line Category of research question Treatment The number and type of study ...
Sarah Long
doaj +1 more source
Can straw based enrichment treat tail biting in pigs?
Veterinary Evidence, 2022 PICO question Can straw based enrichment be used successfully as a treatment intervention to reduce tail biting injuries in weaner to finisher pigs housed in indoor farming systems?
Abigail Liston
doaj +1 more source
Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy
Advanced Healthcare Materials, EarlyView.Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima +15 more
wiley +1 more source
Using PICO in Library Instruction for STEM Disciplines
, 2017 PICO is understood to support evidence based practice/medicine research, part of the medical and health sciences disciplines. However, very little use of the PICO methodology found outside of these disciplines.
Ritchie, Stephanie
core +1 more source