Results 41 to 50 of about 32,814 (251)

Using PICO Methodology to Answer Questions About Smoking in COPD Patients

Archivos de Bronconeumología (English Edition), 2017
The ALAT and SEPAR Treatment and Control of Smoking Groups have collaborated in the preparation of this document which attempts to answer, by way of PICO methodology, different questions on health interventions for helping COPD patients to stop smoking.
Jiménez Ruiz C.A., Buljubasich D., Riesco Miranda J.A., Acuña Izcaray A., de Granda Orive J.I., Chatkin J.M., Zabert G., Guerreros Benavides A., Paez Espinel N., Noé V., Sánchez-Angarita E., Núñez-Sánchez I., Sansores R.H., Casas A., Palomar Lever A., Alfageme Michavila I.   +15 more
openaire   +2 more sources

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Polychip‐A High‐Throughput Droplet Microfluidics Platform for Interrogating Microbial Interactions

Advanced Science, EarlyView.
Polychip, a fully integrated droplet microfluidics platform, enables high‐throughput, single‐cell resolution screening of polymicrobial interactions. By seamlessly combining six automated microfluidics operations on a single chip, the system accelerates antimicrobial discovery by 11 to 14 times compared to traditional robotic methods.
Jeong Jae Han, Adrian Ryan Guzman, Aifen Zhou, Han Zhang, Rohit Gupte, Haemin Jung, Kaylee Delgado, Sini Skariah, Ali Sultan, Arul Jayaraman, Paul de Figueiredo, Arum Han   +11 more
wiley   +1 more source

An Integrated Practical Evidence-Based Medicine Curriculum: Two Small-Group Sessions to Teach PICO Question Formation and Searching Strategies

MedEdPORTAL, 2013
Introduction The need to teach evidence-based medicine (EBM) goes beyond meeting the requirements of residency. For residents and all practicing physicians, there must be a process to ensure that doctors know the latest and best information to apply to ...
Rachel Boykan, Maribeth Chitkara, Colleen Kenefick, Catherine Messina   +3 more
doaj   +1 more source

Topics in Present-day Science Technology and Innovation: Ultrafast Relaxation Processes in Semiconductors [PDF]

Materials Research, 2015
The nowadays notable development of all the modern technology, fundamental for the progress and well being of world society, imposes a great deal of stress in the realm of basic Physics, more precisely on Thermo-Mechanical Statistics.
Clóves Gonçalves Rodrigues, Áurea Rosas Vasconcellos, Roberto Luzzi   +2 more
doaj   +2 more sources

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Palmitoylation of PSD‐95 Orchestrates Learning‐Dependent Metaplasticity in the Amygdala and Fear Memory

Advanced Science, EarlyView.
This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen, Yu‐Xuan Weng, Zhi‐Xuan Xia, Yue‐Ling Zhao, Qian‐Qian Ding, Si‐Ying Wang, Ting Cao, Xuan‐Ying Chen, Wu‐Cheng Tao, Shen Lin, Zhou Chen, Yi‐Xiao Luo   +11 more
wiley   +1 more source

Comparative efficacy of gambee and single interrupted suture patterns in reducing complications after canine enterotomy

Veterinary Evidence
PICO Question In dogs undergoing enterotomy, does using a Gambee suture pattern instead of a single interrupted suture pattern to close the intestinal incision reduce the risk of postoperative complications?
Anthi Anatolitou, Miltiadis Markou
doaj   +1 more source

EBM Tutorial: Formulating a Clinical Question (Out of Print)

MedEdPORTAL, 2007
Created and maintained by the Boston University Alumni Medical Library, this web-based tutorial designed for self-study can be completed in approximately 5 minutes and can be used to support evidence-based medicine (EBM) practice and curricular ...
Lauren Maggio, John Wiecha, Keven Jeffery, Mary Blanchard   +3 more
doaj   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source