Results 91 to 100 of about 38,240 (235)

Conditional Estimation in Two-stage Adaptive Designs

, 2017
We consider conditional estimation in two-stage sample size adjustable designs and the following bias. More specifically, we consider a design which permits raising the sample size when interim results look rather promising, and, which keeps the ...
Broberg, Per, Miller, Frank
core   +1 more source

Cognitive Efficacy of Quetiapine in Early-Onset First-Episode Psychosis: A 12-Week Open Label Trial [PDF]

, 2018
Twenty-three adolescents with psychotic disorders, aged from 13 to 18years, participated in a 12-week open label trial (17 adolescents completed the study) in order to examine the impact of quetiapine on clinical status and cognitive functions ...
Barcellona, Sandra, Baumann, Pierre, Clarke, Stéphanie, Hafil, Muriel, Halfon, Olivier, Holzer, Laurent, Peter-Favre, Claire, Preuss, Ulrich, Urben, Sébastien   +8 more
core  

L‐carnitine for valproic acid‐induced toxicity

British Journal of Clinical Pharmacology, Volume 91, Issue 3, Page 636-647, March 2025.
Aims Review the effectiveness and dosing of L‐carnitine for valproic‐acid induced toxicity. Methods A literature review of the pharmacokinetics and clinical use of L‐carnitine was performed. Results Valproic acid is a fatty acid used for numerous therapeutic indications ranging from epilepsy to bipolar disorder. The metabolism of valproic acid produces
Tomasz Gziut, Ruben Thanacoody
wiley   +1 more source

Direct and enhanced delivery of nanoliposomes of anti schizophrenic agent to the brain through nasal route

Saudi Pharmaceutical Journal, 2017
The problem of inadequate oral bioavailability of Quetiapine Fumarate, a lipophilic drug used for schizophrenia, due to hepatic metabolism and repulsion by brain barrier was attempted in this study. Combination of two approaches, viz.
Pratik Upadhyay, Jatin Trivedi, Kilambi Pundarikakshudu, Navin Sheth   +3 more
doaj   +1 more source

Successful Treatment of Anemia With Ringed Sideroblasts Induced by Antidepressants Through Vitamin B6 Supplementation and Discontinuation of Antidepressants

Case Reports in Hematology, Volume 2025, Issue 1, 2025.
Vitamin B6 (VB6) is a vital coenzyme for δ‐aminolevulinic acid synthase (ALAS) in heme biosynthesis. We report a 49‐year‐old male with severe microcytic anemia and ringed sideroblasts initially diagnosed as myelodysplastic syndrome (MDS). VB6 deficiency, attributed to long‐term amoxapine use, was identified.
Sanshiro Nakao, Chiaki Nakaseko, Chikako Ohwada, Keisuke Kirito, Asuka Shibamiya, Akane Tanaka, Reiko Watanabe, Naomi Shimizu, Suraiya Saleem   +8 more
wiley   +1 more source

Quetiapine versus Haloperidol in Controlling Conversion Disorder Symptoms; a Randomized Clinical Trial

Archives of Academic Emergency Medicine, 2018
Introduction: About 5% of visits to emergency departments are made up of conversion disorder cases. This study was designed with the aim of comparing the effectiveness of quetiapine and haloperidol in controlling conversion disorder symptoms.
Saeed Reza Ghanbarizadeh, Hossein Dinpanah, Reza Ghasemi, Yaser Salahshour, Samaneh Sardashti, Mostafa Kamali, Seyed Reza Khatibi   +6 more
doaj   +1 more source

Tools for clinical pharmacists to identify medications that can cause drug‐induced cognitive impairment: A systematic review

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 7, Issue 12, Page 1207-1227, December 2024.
Abstract Cognitive impairment affects around 19% of community‐dwelling older adults in the United States. Pharmacists can play a significant role in identifying and deprescribing cognitive‐impairing medications through cognitive‐focused medication reviews or as part of comprehensive medication management.
Jacob Stanton, Michael R. Gionfriddo, Gail B. Rattinger, Yuan Fang, Mia E. Lussier   +4 more
wiley   +1 more source

Psychoses in Pediatric‐Onset Multiple Sclerosis: A Case Report and Systematic Review

Journal of Child and Adolescent Psychiatric Nursing, Volume 37, Issue 4, November 2024.
ABSTRACT Problem The association of pediatric‐onset multiple sclerosis (POMS) and psychosis remains rare and unclear in the literature. We aim to elucidate the association between POMS and psychosis across case reports. Methods We report a case of schizophrenia (SCZ) revealing POMS.
Emna Ellouz, Imen Ketata, Wafa abbes, Hend Gargouri, Sondes Bader   +4 more
wiley   +1 more source

Roles of Fatty Acid Chain Length and Enzyme-Oriented Drug Controlled Release from pH-Triggering Self-Assembled Fatty Acid Conjugated Quetiapine Nanosuspensions

International Journal of Nanomedicine, 2023
Hy D Nguyen,1 Hai V Ngo,1 Van Hong Nguyen,2 Myung-Chul Gil,1,3 Beom-Jin Lee1,4 1College of Pharmacy, Ajou University, Suwon, 16499, Republic of Korea; 2Department of Life Sciences, University of Science and Technology of Hanoi, Vietnam Academy of Science
Nguyen HD, Ngo HV, Nguyen VH, Gil MC, Lee BJ   +4 more
doaj  

Changing the Drug Delivery System: Does It Add to Non-Compliance Ramifications Control? A Simulation Study on the Pharmacokinetics and Pharmacodynamics of Atypical Antipsychotic Drug

Pharmaceutics, 2020
This study investigates the pharmacokinetic (PK) and pharmacodynamic (PD) consequences of shifting from Quetiapine fumarate immediate-release (IR) to extended-release (XR) formulation in non-adherent schizophrenia patients.
Mohammed H. Elkomy
doaj   +1 more source