Results 71 to 80 of about 469,625 (278)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain

Advanced Science, EarlyView.
A new approach uses simple neural networks to create digital twins of brain activity, capturing how different patterns unfold over time. The method generates and recovers key dynamics even from noisy data. When applied to fMRI, it predicts brain signals and reveals distinctive activity patterns across regions and individuals, opening possibilities for ...
Gabriele Di Antonio, Tommaso Gili, Andrea Gabrielli, Maurizio Mattia   +3 more
wiley   +1 more source

Eye quietness and quiet eye in expert and novice golf performance: an electrooculographic analysis [PDF]

, 2017
Quiet eye (QE) is the final ocular fixation on the target of an action (e.g., the ball in golf putting). Camerabased eye-tracking studies have consistently found longer QE durations in experts than novices; however, mechanisms underlying QE are not known.
Cooke, A, Gallicchio, G, Ring, C
core  

Photometric Variability in Kepler Target Stars: The Sun Among Stars -- A First Look [PDF]

, 2010
The Kepler mission provides an exciting opportunity to study the lightcurves of stars with unprecedented precision and continuity of coverage. This is the first look at a large sample of stars with photometric data of a quality that has heretofore been ...
Basri, Gibor, Batalha, Natalie, Borucki, William J., Brown, Tim, Caldwell, Doug, Dupree, Andrea K., Gilliland, Ronald L., Howell, Steve, Jenkins, Jon, Koch, David, Latham, David W., Meibom, Soeren, Walkowicz, Lucianne M.   +12 more
core   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Eye tracking in high-performance sports: Evaluation of its application in expert athletes

International Journal of Computer Science in Sport, 2018
In the last thirty years, an increasing interest in sport sciences regarding the analysis of expert athletes’ gaze behavior has become apparent. This narrative review provides an overview of the use of eye tracking systems in high-performance sports from
Hüttermann S., Noël B., Memmert D.
doaj   +1 more source

Quantifying cognitive function in concussed athletes before and after acute exercise using a choice reaction time task [PDF]

, 2014
Following a concussion, cognitive deficits have been shown to last longer than symptom resolution. Currently clinicians rely heavily on symptom emergence following the fundamental exercises of the return to play (RTP) protocol, which may leave athletes ...
Cinelli, Michael E, Ph.D., Ramautar, Stephanie A, M.Sc.   +1 more
core   +1 more source

M Dwarfs in SDSS Stripe 82: Photometric Light Curves and Flare Rate Analysis

, 2009
We present a flare rate analysis of 50,130 M dwarf light curves in SDSS Stripe 82. We identified 271 flares using a customized variability index to search ~2.5 million photometric observations for flux increases in the u- and g-bands.
Abazajian, Adam F. Kowalski, Adelman-McCarthy, Andrew A. West, Andrew C. Becker, Audard, Becker, Binney, Blanton, Bochanski, Bochanski, Bochanski, Branimir Sesar, Chalabaev, Covey, Covey, Covey, Covey, Eric J. Hilton, Finkbeiner, Finkbeiner, Frieman, Gizis, Gunn, Gunn, Güdel, Hawley, Hawley, Hogg, Ivezić, Ivezić, John J. Bochanski, Jurić, Kaiser, McGehee, Miller, Moore, Ng, Pettersen, Pier, Reid, Reid, Schlegel, Smith, Smolčić, Stoughton, Stoughton, Suzanne L. Hawley, Walkowicz, Welsh, West, West, Wielen, Wilson, York   +54 more
core   +1 more source