Results 161 to 170 of about 1,249,380 (278)

VSED Should Not Be a Pathway to MAiD (Though Both Are Ethically Permissible)

open access: yesBioethics, EarlyView.
ABSTRACT Recent changes in aid in dying laws have led some to argue for a pathway from Voluntarily Stopping Eating and Drinking (VSED) to Medical Aid in Dying (MAiD). Proponents point to the Sontag case as demonstrating the efficacy of the practice. This article first provides an overview of the development of the practice of VSED and MAiD and provides
D. B. Davison
wiley   +1 more source

A Survey of Current Operations-Ready Thermospheric Density Models for Drag Modeling in LEO Operations. [PDF]

open access: yesJ Astronaut Sci
Mutschler S   +10 more
europepmc   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

open access: yesBritish Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes   +7 more
wiley   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

open access: yesBritish Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher   +6 more
wiley   +1 more source

CD93—An emerging vascular target in cancer therapy

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira   +3 more
wiley   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

open access: yesBritish Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff   +3 more
wiley   +1 more source

Investigating the Relationship Between Physical Properties and Spatial Irregularities at Coronal Hole Boundaries. [PDF]

open access: yesSol Phys
Ngampoopun N   +7 more
europepmc   +1 more source

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