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Robustness through variability: ion channel isoform diversity safeguards neuronal excitability
Hilgert S +8 more
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The American Journal of Medicine, 2009
One of the earliest antiarrhythmic drugs developed, quinidine had a significant role in the treatment of many arrhythmias. After concerns for increased risk of ventricular arrhythmia and death with quinidine emerged, the use of quinidine fell dramatically in favor of newer antiarrhythmic medications.
Felix, Yang +3 more
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One of the earliest antiarrhythmic drugs developed, quinidine had a significant role in the treatment of many arrhythmias. After concerns for increased risk of ventricular arrhythmia and death with quinidine emerged, the use of quinidine fell dramatically in favor of newer antiarrhythmic medications.
Felix, Yang +3 more
openaire +2 more sources
Quinidine, “pure quinidine,” and hydroquinidine
American Heart Journal, 1942Abstract 1. 1. Quinidine is composed of about 20 per cent hydroquinidine and 80 per cent “pure quinidine.” 2. 2. “Pure quinidine” is a marked cardiovascular depressant. It is much more toxic than quinidine in doses equivalent to sublethal doses of quinidine. 3. 3.
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