Results 1 to 10 of about 83,070 (278)

Improved Malaria Therapy with Cationic Nanocapsules Demonstrated in Plasmodium berghei-Infected Rodents Using Whole Blood Surrogate Population PK/PD Modeling

Pharmaceutics
Objectives: Investigating how nanoparticle systems interact in whole blood (WB) is critical to evaluating the effectiveness of malaria therapy. Methods: We decided to establish a pharmacokinetic/pharmacodynamic (PK/PD) model of the quinine population in ...
Tamara Ramos Maciel, Ana Claudia Funguetto-Ribeiro, Laura Ben Olivo, Flávia Elizabete Guerra Teixeira, Camila de Oliveira Pacheco, Bibiana Verlindo de Araujo, Sandra Elisa Haas   +6 more
doaj   +1 more source

QUININE IN FEVER. [PDF]

The Lancet
n ...
Gee, Robert, Eddowes, W.-M.
openaire   +2 more sources

Synthesis of (R)-(6-Methoxyquinolin-4-yl)[(1S,2S,4S,5R)-5-vinylquinuclidin-2-yl]methanol Tetraphenylborate Ion-Pair Complex: Characterization, Antimicrobial, and Computational Study

Molecules, 2023
The (R)-(6-Methoxyquinolin-4-yl)[(1S,2S,4S,5R)-5-vinylquinuclidin-2-yl]methanol (quinine)-tetraphenylborate complex was synthesized by reacting sodium tetraphenyl borate with quinine in deionized water at room temperature through an ion-pair reaction ...
Tarek A. Yousef, Haitham Alrabiah, Mohamed H. Al-Agamy, Rashad Al-Salahi, Essam A. Ali, Gamal A. E. Mostafa   +5 more
doaj   +1 more source

"QUININE PARADES." [PDF]

The Lancet, 1916
n ...
openaire   +2 more sources

Synthesis and Biological Activity of Novel Polyazaheterocyclic Derivatives of Quinine

Molecules
A synthetic methodology of the CuAAC “click” approach was exploited for the construction of 1,2-azolyltriazole quinine derivatives by the reaction of O-propargylquinine with azidomethyl-1,2-azoles in methanol.
Gulim K. Mukusheva, Nurizat N. Toigambekova, Roza B. Seidakhmetova, Roza I. Jalmakhanbetova, Mukhlissa N. Babakhanova, Oralgazy A. Nurkenov, Ekaterina A. Akishina, Evgenij A. Dikusar, Irina A. Kolesnik, Hongwei Zhou, Vladimir I. Potkin   +10 more
doaj   +1 more source

Drug-induced immune thrombocytopenia: Mapping of the drug binding site to the membrane-proximal region of platelet GPIX

Platelets, 2019
Drug-induced Immune thrombocytopenia (DIT) is a common complication of several medications, including commonly used antibiotics. The most widely studied DIT is caused by quinine. In DIT, antibodies predominantly bind to the platelet membrane glycoprotein
Zohra Ahmadi, Jose Perdomo, Rose Wong, Beng H Chong   +3 more
doaj   +1 more source

Plasmodium falciparum malaria: rosettes are disrupted by quinine, artemisinin, mefloquine, primaquine, pyrimethamine, chloroquine and proguanil

Memorias do Instituto Oswaldo Cruz, 1999
An assay was developed measuring the disruption of rosettes between Plasmodium falciparuminfected (trophozoites) and uninfected erythrocytes by the antimalarial drugs quinine, artemisinin mefloquine, primaquine, pyrimethamine, chloroquine and proguanil ...
JP Dean Goldring, Thanugarani Padayachee, Imraan Ismail   +2 more
doaj   +1 more source

ADULTERATION OF QUININE. [PDF]

The Lancet
n ...
openaire   +2 more sources

QUININE IN PNEUMONIA. [PDF]

The Lancet, 1885
n ...
openaire   +2 more sources

Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil

Brazilian Journal of Infectious Diseases
We examined the plasmatic concentrations of quinine in patients with uncomplicated falciparum malaria in an endemic area of the Amazon region in Brazil in a prospective clinical trial, in which a standard three-day course of oral quinine plus doxycycline
José Luiz Fernandes Vieira, Larissa Maria Guimarães Borges, Margareth Tavares Silva Nascimento, Andreza de L.S. Gomes   +3 more
doaj   +1 more source