Results 31 to 40 of about 104,109 (228)

Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria

Malaria Journal, 2011
Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was first documented. However, its continued use is challenged by its poor tolerability, poor compliance with complex dosing regimens, and the availability of more ...
Baliraine Frederick N, Tibenderana James K, Yeka Adoke, Erhart Annette, Talisuna Ambrose O, Achan Jane, Rosenthal Philip J, D'Alessandro Umberto   +7 more
doaj   +1 more source

Quinine Sulphate Microparticles as Treatment for Leishmaniasis

Journal of Tropical Medicine, 2020
Background. Leishmaniasis is a neglected tropical disease caused by the Leishmania parasite and transmitted by the female phlebotomine sandfly. The disease can affect the skin (least fatal) or internal organs (most fatal).
Grace Lovia Allotey-Babington, Seth Kwabena Amponsah, Thomas Nettey, Clement Sasu, Henry Nettey   +4 more
doaj   +1 more source

Mefloquine resistant malaria in cameroon and correlation with resistance quinine

Memorias do Instituto Oswaldo Cruz, 1992
Based on the results of in vitro sensitivity of Plasmodium falciparum to chloroquine, quinine and mefloquine, and evaluation of drug consumption conducted in 1987-1988 in four areas in the noth and south-west of Cameron, two opposite situations were ...
P. Brasseur, J. Kouamouo, R. S. Moyou, P. Druilhe   +3 more
doaj   +1 more source

Beyond Antimalarial Stock-outs: Implications of Health Provider Compliance on Out-of-Pocket Expenditure during Care-Seeking for Fever in South East Tanzania. [PDF]

, 2013
To better understand how stock-outs of the first line antimalarial, Artemisinin-based Combination Therapy (ACT) and other non-compliant health worker behaviour, influence household expenditures during care-seeking for fever in the Ulanga District in ...
Abdallah, Gumi, Amuri, Baraka, de Savigny, Don, Khatib, Rashid, Manzi, Fatuma, Mikkelsen-Lopez, Inez, Njozi, Mustafa, Tediosi, Fabrizio   +7 more
core   +2 more sources

Improved Malaria Therapy with Cationic Nanocapsules Demonstrated in Plasmodium berghei-Infected Rodents Using Whole Blood Surrogate Population PK/PD Modeling

Pharmaceutics
Objectives: Investigating how nanoparticle systems interact in whole blood (WB) is critical to evaluating the effectiveness of malaria therapy. Methods: We decided to establish a pharmacokinetic/pharmacodynamic (PK/PD) model of the quinine population in ...
Tamara Ramos Maciel, Ana Claudia Funguetto-Ribeiro, Laura Ben Olivo, Flávia Elizabete Guerra Teixeira, Camila de Oliveira Pacheco, Bibiana Verlindo de Araujo, Sandra Elisa Haas   +6 more
doaj   +1 more source

Application of NIR handheld transmission spectroscopy and chemometrics to assess the quality of locally produced antimalarial medicines in the Democratic Republic of Congo

Talanta Open, 2021
In recent decades, more than 15% of the antimalarials marketed in low- and middle-income countries have been of poor quality, in which quinoline derivatives and quinine-based formulations account for 21%.Near infrared spectroscopy (NIR) was chosen for ...
P.H. Ciza, P-Y. Sacre, M.R. Kanyonyo, C.T. Waffo, M.A. Borive, L. Coïc, J.K. Mbinze, Ph. Hubert, E. Ziemons, R.D. Marini   +9 more
doaj   +1 more source

Quinine blocks 5-HT and 5-HT3 receptor mediated peristalsis in both guinea pig and mouse ileum tissue [PDF]

, 2011
Introduction. Quinine is commonly used to treat malaria; however one of the principal side effects is gastrointestinal disturbances (White, 1992). 5-HT3 receptors modulate gut peristalsis (Chetty et al., 2006), and, as quinine has been shown to act as a ...
Barrett, Iain D., Kelley, Stephen P., Lummis, Sarah, Thompson, Andrew J., Walsh, Jacqueline   +4 more
core  

A Reusable Polymeric Sensor Based on Green‐Synthesized CQDs@ZIF‐8 for the Rapid Detection of Nitro‐Explosive Picric Acid

Advanced Materials Interfaces, EarlyView.
This study presents the rational design and synthesis of a highly luminescent polymeric nanocomposite. Initially, highly fluorescent carbon quantum dots (CQDs) are synthesized via a facile hydrothermal method using citric acid and β‐alanine as precursors, followed by rigorous purification through centrifugation and filtration.
Yunus Emre Toprak, Soner Çubuk, Memet Vezir Kahraman   +2 more
wiley   +1 more source

A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum. [PDF]

PLoS Genetics, 2014
The emerging resistance to quinine jeopardizes the efficacy of a drug that has been used in the treatment of malaria for several centuries. To identify factors contributing to differential quinine responses in the human malaria parasite Plasmodium ...
Cecilia P Sanchez, Chia-Hao Liu, Sybille Mayer, Astutiati Nurhasanah, Marek Cyrklaff, Jianbing Mu, Michael T Ferdig, Wilfred D Stein, Michael Lanzer   +8 more
doaj   +1 more source

Quinine doped hybrid sol-gel coatings for wave guiding and optical applications [PDF]

, 2012
Pure and quinine doped silica coatings have been prepared over sodalime glasses. The coatings were consolidated at low temperature (range 60-180 A degrees C) preserving optical activity of quinine molecule.
A Li, C Choi, CJ Brinker, D Levy, E. Enríquez, EF Montero, EF Montero, F Gonella, FM Shiu, GC Righini, GV Joshi, GW Arnold, H Mishra, J. F. Fernández, JC Dubois, JE Vitt, JM Senior, JR Lakowicz, L Yang, LC Klein, LH Hench, LYL Wu, M Asomoza, M Pakizeh, M. A. de la Rubia, M. A. Garcia, MA García, MA García, MA Meneses-Nava, MA Meneses-Nava, MA Villegas, MJ Adams, MS Hosseini, N. Carmona, NA Rey, P Mazzoldi, PD Townsend, R Caruso, RF Chen, RP Spiers, S Sakka, SG Schulman, SI Najafi   +42 more
core   +5 more sources