Results 21 to 30 of about 83,070 (278)
A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum. [PDF]
PLoS Genetics, 2014 The emerging resistance to quinine jeopardizes the efficacy of a drug that has been used in the treatment of malaria for several centuries. To identify factors contributing to differential quinine responses in the human malaria parasite Plasmodium ...
Cecilia P Sanchez +8 more
doaj +2 more sources
Quinine Sulphate Microparticles as Treatment for Leishmaniasis
Journal of Tropical Medicine, 2020 Background. Leishmaniasis is a neglected tropical disease caused by the Leishmania parasite and transmitted by the female phlebotomine sandfly. The disease can affect the skin (least fatal) or internal organs (most fatal).
Grace Lovia Allotey-Babington +4 more
doaj +2 more sources
In Silico ADME/T Properties of Quinine Derivatives using SwissADME and pkCSM Webservers
International Journal of TROPICAL DISEASE & Health, 2021 Aim: Malaria is among the most devastating and widespread tropical parasitic diseases. To overcome antimalarial drug resistance, new drugs need to be developed.
Jean Gonfi M. Mvondo +5 more
semanticscholar +1 more source
Quinine-Induced Thrombotic Microangiopathy: A Report of 19 Patients
American Journal of Kidney Diseases, 2017 Dustin J Little +2 more
exaly +2 more sources
Early and Late Steps of Quinine Biosynthesis
Organic Letters, 2021 The enzymatic basis for quinine 1 biosynthesis was investigated. Transcriptomic data from the producing plant led to the discovery of three enzymes involved in the early and late steps of the pathway.
F. Trenti +5 more
semanticscholar +1 more source
Poultry Science, 2021 : Histomoniasis, also commonly referred to as blackhead disease, is caused by the protozoan parasite Histomonas meleagridis. Since the removal of nitarsone in 2015, no approved prophylactics are available for mitigating histomoniasis.
L.C. Beer, B.M. Hargis, C.N. Vuong
doaj +1 more source
The Role of Anterior Insular Parvalbumin GABAergic Interneurons in Impulsivity-Related and Alcohol-Seeking Behaviors. [PDF]
CNS Neurosci TherAdolescent impulsivity is linked to increased alcohol seeking and altered activation of anterior insular PV interneurons. Chemogenetic modulation of these neurons regulates inhibitory control and alcohol‐related behaviors, highlighting their role in vulnerability to alcohol use disorder.
Bezerra F +8 more
europepmc +2 more sources
Aptamer-based nanotrains and nanoflowers as quinine delivery systems
International Journal of Pharmaceutics: X, 2023 In this study, we designed aptamer-based self-assemblies for the delivery of quinine. Two different architectures were designed by hybridizing quinine binding aptamers and aptamers targeting Plasmodium falciparum lactate dehydrogenase (PfLDH): nanotrains
Mengyuan Cao +10 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Polymer-based vehicles that controllably deliver therapeutic nucleic acids to cells show great potential to develop safe and effective gene therapies. Realizing this potential, however, is limited by the lack of understanding of how polymers
C. Van Bruggen +6 more
semanticscholar +1 more source
Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction [PDF]
Journal of Pure and Applied Chemistry Research, 2020 Concept the role played by modified quinine in the asymmetric hydroxyl group inspired studies of modified quinine as chiral organic that lead to drug discovery development.
Teni Ernawati +2 more
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