Results 21 to 30 of about 49,957 (191)
Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria
Malaria Journal, 2011 Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was first documented. However, its continued use is challenged by its poor tolerability, poor compliance with complex dosing regimens, and the availability of more ...
Baliraine Frederick N +7 more
doaj +1 more source
Missionaries and the Politics of Quinine in the Gold Coast (1939-1943) [PDF]
Journal of Research on History of Medicine, 2022 While there exists a rich history on anti-malarial drugs and quinine, in particular, the attention of scholars has not reflected the nexuses between the Second World War, quinine shortage and missionaries in the Gold Coast.
Benjamin Darkwa
doaj
Mefloquine resistant malaria in cameroon and correlation with resistance quinine
Memorias do Instituto Oswaldo Cruz, 1992 Based on the results of in vitro sensitivity of Plasmodium falciparum to chloroquine, quinine and mefloquine, and evaluation of drug consumption conducted in 1987-1988 in four areas in the noth and south-west of Cameron, two opposite situations were ...
P. Brasseur +3 more
doaj +1 more source
PharmaceuticsObjectives: Investigating how nanoparticle systems interact in whole blood (WB) is critical to evaluating the effectiveness of malaria therapy. Methods: We decided to establish a pharmacokinetic/pharmacodynamic (PK/PD) model of the quinine population in ...
Tamara Ramos Maciel +6 more
doaj +1 more source
A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum. [PDF]
PLoS Genetics, 2014 The emerging resistance to quinine jeopardizes the efficacy of a drug that has been used in the treatment of malaria for several centuries. To identify factors contributing to differential quinine responses in the human malaria parasite Plasmodium ...
Cecilia P Sanchez +8 more
doaj +1 more source
Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients
British Journal of Clinical Pharmacology, EarlyView.Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Anna Sofie Buhl Rasmussen +14 more
wiley +1 more source
Molecules, 2023 The (R)-(6-Methoxyquinolin-4-yl)[(1S,2S,4S,5R)-5-vinylquinuclidin-2-yl]methanol (quinine)-tetraphenylborate complex was synthesized by reacting sodium tetraphenyl borate with quinine in deionized water at room temperature through an ion-pair reaction ...
Tarek A. Yousef +5 more
doaj +1 more source