Results 11 to 20 of about 83,070 (278)
Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro
Frontiers in Pharmacology, 2019 Cytochrome P450 3A4 (CYP3A4) enzyme activity is known to show considerable ethnic heterogeneity and inter-individual differences, affecting the outcome of drug treatment.
Xiao-Yang Zhou +7 more
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Effects of Quinine, Quinidine and Chloroquine on Human Muscle Nicotinic Acetylcholine Receptors
Frontiers in Pharmacology, 2018 The genus Cinchona is known for a range of alkaloids, such as quinine, quinidine, cinchonine, and cinchonidine. Cinchona bark has been used as an antimalarial agent for more than 400 years.
Günter Gisselmann +3 more
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Frontiers in Immunology, 2018 BackgroundBitter (T2R) and sweet (T1R) taste receptors in the airway are important in innate immune defense, and variations in taste receptor functionality in one T2R (T2R38) correlate with disease status and disease severity in chronic rhinosinusitis ...
Alan D. Workman +14 more
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Quinine Inhibits Infection of Human Cell Lines with SARS-CoV-2
Viruses, 2021 While vaccination campaigns are ongoing worldwide, there is still a tremendous medical need for efficient antivirals against SARS-CoV-2 infection. Among several drug candidates, chloroquine (CQN) and hydroxychloroquine (H-CQN) were tested intensively ...
Maximilian Große +12 more
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Angewandte Chemie - International Edition, 2018 We report a novel approach to the classical natural product quinine that is based on two stereoselective key steps, namely a C−H activation and an aldol reaction, to unite the two heterocyclic moieties of the target molecule.
Martin Berger +2 more
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Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria
Malaria Journal, 2011 Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was first documented. However, its continued use is challenged by its poor tolerability, poor compliance with complex dosing regimens, and the availability of more ...
Baliraine Frederick N +7 more
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Stimulation of Erythrocyte Cell Membrane Scrambling by Quinine
Cellular Physiology and Biochemistry, 2016 Background/Aims: The analkaloid drug quinine is utilized mainly for the chemoprophylaxis of malaria. The multiple side effects of quinine include hemolytic anemia and hemolytic uremic syndrome, disorders involving suicidal erythrocyte death or eryptosis,
Morena Mischitelli +4 more
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Aversion to Quinine is Associated with Taste Sensation in Chicks
The Journal of Poultry Science, 2005 Quinine is known as a bitter compound for humans and also used in animal experiment. However, there is no evidence that animals share the same taste sensation of quinine with humans.
Hiroshi Ueda, Saori Kainou
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The Pharmacochaperone Activity of Quinine on Bitter Taste Receptors.
PLoS ONE, 2016 Bitter taste is one of the five basic taste sensations which is mediated by 25 bitter taste receptors (T2Rs) in humans. The mechanism of bitter taste signal transduction is not yet elucidated.
Jasbir D Upadhyaya +5 more
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Regulation of Adipogenesis by Quinine through the ERK/S6 Pathway
International Journal of Molecular Sciences, 2016 Quinine is a bitter tasting compound that is involved in the regulation of body weight as demonstrated in in vivo animal models and in vitro models of the adipogenic system.
Xin'e Shi, Gongshe Yang
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