Results 51 to 60 of about 83,070 (278)

Clindamycin plus quinine for treating uncomplicated falciparum malaria: a systematic review and meta-analysis

Malaria Journal, 2012
Background Artemisinin-based combinations are recommended for treatment of uncomplicated falciparum malaria, but are costly and in limited supply. Clindamycin plus quinine is an alternative non-artemisinin-based combination recommended by World Health ...
Obonyo Charles O, Juma Elizabeth A
doaj   +1 more source

First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: A meta-analysis of observational studies

PLoS Medicine, 2017
Background Animal embryotoxicity data, and the scarcity of safety data in human pregnancies, have prevented artemisinin derivatives from being recommended for malaria treatment in the first trimester except in lifesaving circumstances.
Stephanie Dellicour, Esperança Sevene, R. McGready, H. Tinto, D. Mosha, C. Manyando, S. Rulisa, M. Desai, P. Ouma, M. Oneko, Anifa Vala, M. Rupérez, E. Macete, C. Menéndez, S. Nakanabo-Diallo, Adama Kazienga, I. Valéa, G. Calip, Orvalho Augusto, B. Genton, Eric M. Njunju, Kerryn A. Moore, U. D'Alessandro, F. Nosten, F. T. ter Kuile, Andy Stergachis   +25 more
semanticscholar   +1 more source

Feasibility and acceptability of injectable artesunate for the treatment of severe malaria in the Democratic Republic of Congo [PDF]

, 2016
The Democratic Republic of the Congo (DRC) changed its national policy for the treatment of severe malaria in both children and adults in 2012 from intravenous quinine to injectable artesunate.
Lengeler, Christian, Henry M. T. Ntuku, Tshefu, Antoinette K., Christian Lengeler, Ntuku Et Al. Malar J, Christian Burri, Antoinette K. Tshefu, Kalemwa, Didier M., Henry M. T. Ntuku, Gianfrancesco Ferrari, Burri, Christian, Didier M. Kalemwa, Ferrari, Gianfrancesco, Ntuku, Henry M. T.   +13 more
core   +1 more source

Behavioral Responses of Chicks to a Saccharin-Quinine Mixture

The Journal of Poultry Science, 2018
To date, few reports have been published on the sensitivity of birds to sweet tastes. Therefore, in this study, the behavioral responses of White Leghorn chicks to the sweet taste of saccharin and the bitter taste of quinine were assessed.
Tatsuyuki Yoshida, Yuichi Ito, Hiroki Furuta   +2 more
doaj   +1 more source

Missionaries and the Politics of Quinine in the Gold Coast (1939-1943) [PDF]

Journal of Research on History of Medicine, 2022
While there exists a rich history on anti-malarial drugs and quinine, in particular, the attention of scholars has not reflected the nexuses between the Second World War, quinine shortage and missionaries in the Gold Coast.
Benjamin Darkwa
doaj  

An electrochemical quinine detection approach based on small molecule promoted split aptamer click ligation reaction.

Talanta: The International Journal of Pure and Applied Analytical Chemistry
Quinine is a natural antimalarial drug that also serves as a food additive; however, excessive consumption can result in harmful side effects. Here, we propose a simple and cost-effective electrochemical strategy for quinine detection based on the small ...
Xuan Luo, Susu Cui, Wei-Wei Yang, Yong-Sheng Yu   +3 more
semanticscholar   +1 more source

New Insights into Quinine–DNA Binding Using Raman Spectroscopy and Molecular Dynamics Simulations

Journal of Physical Chemistry B, 2018
Quinine’s ability to bind DNA and potentially inhibit transcription and translation has been examined as a mode of action for its antimalarial activity.
David Punihaole, Riley J Workman, Shiv Upadhyay, C. Van Bruggen, Andrew J. Schmitz, T. Reineke, R. Frontiera   +6 more
semanticscholar   +1 more source

Mefloquine resistant malaria in cameroon and correlation with resistance quinine

Memorias do Instituto Oswaldo Cruz, 1992
Based on the results of in vitro sensitivity of Plasmodium falciparum to chloroquine, quinine and mefloquine, and evaluation of drug consumption conducted in 1987-1988 in four areas in the noth and south-west of Cameron, two opposite situations were ...
P. Brasseur, J. Kouamouo, R. S. Moyou, P. Druilhe   +3 more
doaj   +1 more source

Inhibition of native 5-HT3 receptor-evoked contractions in Guinea pig and mouse ileum by antimalarial drugs [PDF]

, 2014
Quinine, Chloroquine and mefloquine are commonly used to treat malaria; however with associated gastrointestinal (GI) side-effects. These drugs act as antagonists at recombinant 5-HT3 receptors and modulate gut peristalsis.
Walsh, Jacqueline M., Muhdar, Simerjyot, Walsh, Jacqueline, Wildman, Scott S.P., Wildman, Scott S., Barrett, Iain D., Adel-Aziz, Mohammed, Kelley, Stephen P., Wildman, Scott, Kelly, Mark C.   +9 more
core   +1 more source

Artemisinins [PDF]

, 2005
Artemisinins were discovered to be highly effective antimalarial drugs shortly after the isolation of the parent artemisinin in 1971 in China. These compounds combine potent, rapid antimalarial activity with a wide therapeutic index and an absence of ...
C J Woodrow, S Krishna, Woodrow, C. J., Haynes, R. K., Woodrow, CJ, Krishna, S., Haynes, RK, Krishna, S, R K Haynes   +8 more
core   +1 more source