Results 51 to 60 of about 104,109 (228)
Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil
Brazilian Journal of Infectious DiseasesWe examined the plasmatic concentrations of quinine in patients with uncomplicated falciparum malaria in an endemic area of the Amazon region in Brazil in a prospective clinical trial, in which a standard three-day course of oral quinine plus doxycycline
José Luiz Fernandes Vieira +3 more
doaj +1 more source
Demethylation of Quinine Using Anhydrous Aluminium Trichloride
Journal of Mathematical and Fundamental Sciences, 2013 Quinine is a natural alkaloid having a methoxy group bound to quinoline ring and an allyl group bound to quinuclidine ring. Demethylation of quinine applying strong acid such as HBr or HI at high temperature was unsuccessful. The aim of this research was
Aiyi Asnawi +3 more
doaj +1 more source
Artemisinin: From Chinese Herbal Medicine to Modern Chemotherapy [PDF]
, 2019 Malaria is a disease that has blighted humankind since early times. The first antimalarial treatment available to Europeans was the dried bark of the cinchona tree from Peru. The main problem in its use was adulteration by other material.
Butler, Anthony
core +1 more source
Synthesis and Characterization of Carbazole‐Containing Aza[7]helicenes
Chemistry – A European Journal, EarlyView.Double ortho fusion led to different aza[7]helicene frameworks showing strong acidochromic behavior, singlet excited energies being more than twice the triplet energy, and high racemization barriers, allowing chiral resolution and ECD measurements. ABSTRACT Azahelicenes have attracted significant interest due to their intrinsic axial chirality and ...
Inka Marten +2 more
wiley +1 more source
Quinine Inhibits Infection of Human Cell Lines with SARS-CoV-2
Viruses, 2021 While vaccination campaigns are ongoing worldwide, there is still a tremendous medical need for efficient antivirals against SARS-CoV-2 infection. Among several drug candidates, chloroquine (CQN) and hydroxychloroquine (H-CQN) were tested intensively ...
Maximilian Große +12 more
doaj +1 more source
Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib
Clinical Pharmacology &Therapeutics, EarlyView.Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi +5 more
wiley +1 more source
The Pharmacochaperone Activity of Quinine on Bitter Taste Receptors.
PLoS ONE, 2016 Bitter taste is one of the five basic taste sensations which is mediated by 25 bitter taste receptors (T2Rs) in humans. The mechanism of bitter taste signal transduction is not yet elucidated.
Jasbir D Upadhyaya +5 more
doaj +1 more source
Barriers to prompt and effective treatment of malaria in northern Sri Lanka. [PDF]
, 2002 BACKGROUND: For the past 18 years, northern Sri Lanka has been affected by armed ethnic conflict. This has had a heavy impact on displacement of civilians, health delivery services, number of health professionals in the area and infrastructure. The north
Abeyasinghe, R +2 more
core +3 more sources
Carbon Dots: An Emerging Frontier for Green and Sustainable Civil Engineering Materials
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.Traditional civil engineering materials (CE materials) are usually involved with high‐energy consumption during manufacturing, significant maintenance costs, and substantial environmental impacts throughout their life cycles. The progress of nanotechnology is catalyzing a green and sustainable transformation within the field.
Weiwen Hao +5 more
wiley +1 more source
Des «nanotransporteurs» d’ADN : Repousser les limites des Nanomédicaments pour traiter le cancer
Journal de la Faculté de Médecine d'Oran, 2022 Une nouvelle classe de transporteurs de médicaments fabriqués avec de l’ADN, qui pourrait améliorer de façon importante le traitement des cancers et d’autres maladies, a été conçue et validée par une équipe de chercheur de l’université de Montréal ...
Djawad Chikh
doaj +1 more source