Results 71 to 80 of about 83,070 (278)
Demethylation of Quinine Using Anhydrous Aluminium Trichloride
Journal of Mathematical and Fundamental Sciences, 2013 Quinine is a natural alkaloid having a methoxy group bound to quinoline ring and an allyl group bound to quinuclidine ring. Demethylation of quinine applying strong acid such as HBr or HI at high temperature was unsuccessful. The aim of this research was
Aiyi Asnawi +3 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.We report a cellular membrane‐targeted europium(III) probe, Eu.Chol, that enables selective, time‐resolved detection of peroxynitrite (ONOO−) at the cell membrane interface. Eu.Chol demonstrates efficient incorporation into liposomes and Jurkat cells, with minimal response to H2O2, establishing a modular platform for subcellular ONOO− sensing ...
Jamie Webb +6 more
wiley +1 more source
, 2001 We conducted a meta-analysis using individual patient data from randomized controlled trials comparing artemether and quinine in severe falciparum malaria. Eleven trials were identified, of which 8 were clearly randomized.
Artemether-Quinine Meta-analysis Study Group
core +1 more source
The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5-HT 3 receptors [PDF]
, 2007 Background and Purpose: The antimalarial compounds quinine, chloroquine and mefloquine affect the electrophysiological properties of Cys-loop receptors and have structural similarities to 5-HT3 receptor antagonists.
M Lochner +5 more
core +1 more source
Detection, quantification, and investigation of the red blood cell partitioning of cryptolepine hydrochloride [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2018 Context: The fight against malaria is limited by the development of resistance of Plasmodium to medication. This has led to an urgent search for alternative medicinal agents.
Regina A. Kwakye +3 more
doaj
Des «nanotransporteurs» d’ADN : Repousser les limites des Nanomédicaments pour traiter le cancer
Journal de la Faculté de Médecine d'Oran, 2022 Une nouvelle classe de transporteurs de médicaments fabriqués avec de l’ADN, qui pourrait améliorer de façon importante le traitement des cancers et d’autres maladies, a été conçue et validée par une équipe de chercheur de l’université de Montréal ...
Djawad Chikh
doaj +1 more source
International Journal of Molecular Sciences, 2016 Diastereoisomers of quinidine and quinine are used to treat arrhythmia and malaria, respectively. It has been reported that both drugs block the hERG (human ether-a-go-go-related gene) potassium channel which is essential for myocardium repolarization ...
Meng Yan +6 more
semanticscholar +1 more source
Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib
Clinical Pharmacology &Therapeutics, EarlyView.Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi +5 more
wiley +1 more source