Results 81 to 90 of about 49,957 (191)
MicrobiologyOpen, Volume 15, Issue 3, June 2026.Phage therapy shows promising efficacy against MDR, XDR, and PDR Pseudomonas aeruginosa infections across different models and administration routes. Evidence highlights reduced mortality, bacterial clearance, and synergy with antibiotics, while emphasizing the need for standardized protocols and advanced delivery systems to support clinical ...
Gustavo Aparecido da Cunha +7 more
wiley +1 more source
Progress in Natural Products Target Discovery Technology
MedComm, Volume 7, Issue 6, June 2026.Here, we provide a comprehensive overview of current technologies and recent advancements in therapeutic target discovery for natural products. By systematically synthesizing the principles, methodologies, and practical applications of existing experimental and computational strategies, this work provides a more actionable reference framework for ...
Qiyuan Pan +7 more
wiley +1 more source
ChemistryOpen, Volume 15, Issue 6, June 2026.Evaluation of the impact of acidic dopants (HCl vs. H2SO4) on bio‐derived luffa/polyaniline composites for methylene blue adsorption. Sustainable and low‐cost Luffa cylindrica/polyaniline (LC/PAN) composite adsorbents were developed for the removal of methylene blue (MB) from aqueous solutions. The effect of acid dopants (hydrochloric acid and sulfuric
Rayane Mehennaoui +5 more
wiley +1 more source
Toward Novel COVID-19 Therapeutics: In Silico Discovery of Quinine-Based SARS-CoV-2 Mpro Inhibitors
Bulletin of Pharmaceutical Sciences. Assiut UniversitySARS-CoV-2 variants continue to pose a global health threat. This study evaluated twenty-one quinine derivatives as potential inhibitors of the viral main protease (Mpro) using an integrated in silico workflow combining molecular docking, molecular ...
Ahmed Sabri Cherrak +7 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 1999 From March 1996 to August 1997, a study was carried out in a malaria endemic area of the Brazilian Amazon region. In vivo sensitivity evaluation to antimalarial drugs was performed in 129 patients.
Crispim Cerutti Junior +7 more
doaj +1 more source
ChemistrySelect, Volume 11, Issue 21, 4 June 2026.The synthesized probe (SMAK) is the first bis(arylidene)ketone derivative for hypochlorite sensing. It was prepared in one step following two alternative routes; the traditional solution method and a greener solvent‐free method. Probe was found to have excellent selectivity over interfering anions, cations and oxidants and the mechanism of sensing and ...
Dimitris Matiadis +3 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 11, Page 3111-3128, June 2026.Abstract Background and Purpose Alcohol abuse and affective disorders are severe comorbid psychiatric diseases characterized by impaired brain synaptic transmission. The role of presynaptic scaffolding proteins coordinating presynaptic plasticity and neurotransmitter release, such as Bassoon (Bsn), in the pathogenesis of these disorders remains elusive.
Liubov S. Kalinichenko +14 more
wiley +1 more source
Synthesis and Characterization of Carbazole‐Containing Aza[7]helicenes
Chemistry – A European Journal, Volume 32, Issue 19, 22 May 2026.Double ortho fusion led to different aza[7]helicene frameworks showing strong acidochromic behavior, singlet excited energies being more than twice the triplet energy, and high racemization barriers, allowing chiral resolution and ECD measurements. ABSTRACT Azahelicenes have attracted significant interest due to their intrinsic axial chirality and ...
Inka Marten +2 more
wiley +1 more source