Results 91 to 100 of about 33,933 (196)

A Critical Analysis of the Impact of Etoposide as a Topoisomerase II Inhibitor in Cervical Cancer Treatment: A Review

open access: yesCancer Medicine, Volume 15, Issue 3, March 2026.
Etoposide mediated topoisomerase II inhibition in Cervical Cancer. ABSTRACT Background Etoposide is a semisynthetic derivative of podophyllotoxin and an FDA‐approved topoisomerase II inhibitor that induces DNA strand breaks leading to cancer cell death.
Nikitha Kotian   +3 more
wiley   +1 more source

Kawasaki Disease Accompanied by Acute Generalized Exanthematous Pustulosis

open access: yesClinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Acute generalized exanthematous pustulosis (AGEP) is a rare but serious adverse skin reaction usually caused by drugs. We reported a 4‐year‐old boy diagnosed with Kawasaki disease (KD) accompanied by AGEP who presented with typical symptoms of KD, including fever, scarlet‐like rash, swollen extremities, cervical lymph node swelling ...
Wen Li   +4 more
wiley   +1 more source

Rational Design and Functional Optimization of Surface‐Enhanced Raman Spectroscopy Substrates: From Material Engineering to Bioanalysis

open access: yesChemistryEurope, Volume 4, Issue 3, March 2026.
This review presents a rational design framework for high‐performance surface‐enhanced Raman spectroscopy (SERS) substrates enabling ultrasensitive detection. It first elucidates the dual enhancement mechanisms, namely the dominant electromagnetic enhancement arising from localized surface plasmon resonances and the complementary chemical enhancement ...
Xinwei Zhang   +9 more
wiley   +1 more source

Diversity, transfer potential, and transcriptional activity of virus‐carried antibiotic resistance genes in global estuaries

open access: yesiMetaOmics, Volume 3, Issue 1, March 2026.
Estuaries are vital hotspots for antibiotic resistance genes (ARGs) due to substantial antibiotic pollution. Although viruses have been proposed as key reservoirs and important disseminators of ARGs in environments, their contribution to the estuarine antibiotic resistome remains largely unknown.
Xiao‑Qing Luo   +9 more
wiley   +1 more source

Microbiome‐urothelium crosstalk in bladder cancer: From dysbiosis to clinical translation

open access: yesiMetaOmics, Volume 3, Issue 1, March 2026.
This review elucidates the critical crosstalk between the urobiome and bladder cancer (BCa), mapping the landscape from ecological dysbiosis to clinical translation. We synthesize emerging evidence on microbial signatures that distinguish BCa patients, exploring key carcinogenic mechanisms including chronic inflammation, genotoxicity, and the gut ...
Haoxiang Xu   +14 more
wiley   +1 more source

Bacteriophage Therapy: Current Strategies and Future Perspectives

open access: yesMedComm, Volume 7, Issue 3, March 2026.
This manuscript systematically reviews the expanding scope of phage applications. It moves beyond traditional antibacterial use to explore their role in precision therapies against drug‐resistant infections, their synergy with antibiotics, and advanced biomaterial‐assisted delivery systems.
Zihe Zhou   +7 more
wiley   +1 more source

A Case of Effective Long‐Term Tobramycin Inhalation in a Patient With Bronchiectasis and Refractory Pseudomonas aeruginosa Infection

open access: yesRespirology Case Reports, Volume 14, Issue 3, March 2026.
We report a case of bronchiectasis with persistent P. aeruginosa infection successfully managed with inhaled tobramycin after long‐term macrolide therapy failed to prevent recurrent exacerbations. ABSTRACT Bronchiectasis predisposes patients to refractory airway infections and significantly reduces their quality of life.
Yasuaki Kotetsu   +9 more
wiley   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

open access: yesSmall, Volume 22, Issue 16, 17 March 2026.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti   +5 more
wiley   +1 more source

Photogeneration of Hydrogen in Water via Self‐Assembly‐Induced Colloidal Covalent Organic Framework Particles

open access: yesSmall Science, Volume 6, Issue 3, March 2026.
A surfactant‐free strategy using a functional Poly(DiMethylAminoEthylMethAcrylate) polybase enables stable colloidal imine‐linked COFs formation via self‐assembly‐induced process. A dual effect is demonstrated with the control in size and stabilization in colloidal state of the COFs in situ synthesized.
Axelle Larrieu   +3 more
wiley   +1 more source

Assessment of Blood Profiles and Pain in Sport Horses Undergoing Intrarectal Ozone Therapy

open access: yesVeterinary Medicine and Science, Volume 12, Issue 2, March 2026.
Ozone therapy influenced haemoglobin, MCHC, and AST activity in horses, with transient red blood cell deformities and increased pain scores observed. No clinical symptoms or liver damage occurred. Findings suggest that lower ozone concentrations may reduce treatment‐related discomfort while maintaining therapeutic effects.
Thamirys Dias de Luna Paiva   +5 more
wiley   +1 more source

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