Results 91 to 100 of about 60,375 (278)

Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin : polar myosin II inhibitors with superior research tool properties [PDF]

, 2017
In search of myosin II inhibitors with superior research tool properties, a chemical optimization campaign of the blebbistatin scaffold was conducted in this paper. (S)-Blebbistatin is the best known small-molecule inhibitor of myosin II ATPase activity.
Bracke, Marc, De Wever, Olivier, Roman, Bart, Stevens, Christian, Van Deun, Rik, Van Hecke, Kristof, Verhasselt, Sigrid   +6 more
core   +1 more source

Is It an Intrapericardial Mass or a Localized Pericardial Effusion? A Case Report of Tuberculous Pericarditis Evaluated by Multimodal Imaging

Journal of Clinical Ultrasound, EarlyView.
Tuberculous pericarditis is a common type of pericarditis, but it is difficult to be diagnosed. The application of combined transesophageal echocardiography, contrast echocardiography, and CT multimodal imaging provides sufficient clinical diagnosis basis and guidance for distinguishing encapsulated pericardial effusion or mass.
Yang Han, Bingbing Liu, Yonghuai Wang, Fei Xia, Jun Yang, Chunyan Ma   +5 more
wiley   +1 more source

19F NMR Relaxometry and Diffusometry for Measuring Cargo Molecule Dynamics in GelMA Hydrogels

Macromolecular Materials and Engineering, EarlyView.
In this research, fluorine drug dynamics in GelMA hydrogels are measured through fluorine‐19 nuclear magnetic resonance (19F NMR) relaxometry and diffusometry. By combining the Solomon–Bloembergen equations and the Stokes–Einstein–Debye relationship, the microscopic dynamic information includes in situ interaction between drugs and polymer networks ...
Chun‐Wei Chang, Bronwin L. Dargaville, Konstantin I. Momot, Dietmar W. Hutmacher   +3 more
wiley   +1 more source

Consumption of antibiotics at St Luke’s Hospital : a critical factor behind the local prevalence of antimicrobial resistance? [PDF]

, 2006
The intensity of antibiotic use in hospital settings is recognised as possibly the most important factor for the selection of antimicrobial resistance. Hospitals are therefore being encouraged to undertake surveillance and benchmarking of antimicrobial ...
Borg, Michael Angelo, Zarb, Peter
core  

Empiric Antibiotic Therapy in the Treatment of Community-acquired Pneumonia in a General Hospital in Saudi Arabia [PDF]

, 2019
Background: Guideline-based empiric antimicrobial therapy is recommended for the treatment of community-acquired pneumonia (CAP). In this study, we evaluate the pattern of empiric antibiotics of CAP patients.
Al-Tawfiq, Jaffar A., Hinedi, Kareem, Momattin, Hisham   +2 more
core   +1 more source

The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications

Medicinal Research Reviews, EarlyView.
ABSTRACT Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo ...
Bence Kontra, Zoltán Mucsi, Janez Ilaš, Petra Dunkel   +3 more
wiley   +1 more source

Determination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybrids [PDF]

, 2015
We have synthesized and examined the antibacterial activity, toxicity and affinity towards bacterial type II topoisomerases of a series of 1,2,4-triazole-ciprofloxacin hybrids.
Agata Paneth, Aleksandra Strzelczyk, Anna Malm, Barbara Kaproń, Barbara Rajtar, Dalhoff, Małgorzata Polz-Dacewicz, Oliphant, Paweł Stączek, Sharma, Tomasz Plech, Urszula Kosikowska, Łukasz Świątek   +12 more
core   +2 more sources

A Systematic Review of Synthetic and Anticancer and Antimicrobial Activity of Quinazoline/Quinazolin‐4‐one Analogues

ChemistryOpen, EarlyView.
Quinazoline represents an important class of heterocycles with diverse medicinal and pharmacological significance. This review systematically examines scholarly efforts toward understanding different synthetic pathways emphasizing the role of metal and non‐metal catalysts including some miscellaneous reagents employed in the synthesis of quinazoline ...
Neha Manhas, Gobind Kumar, Sanjeev Dhawan, Talent Makhanya, Parvesh Singh   +4 more
wiley   +1 more source

Synthesis of new piperazinyl quinolones and investigation of their in vitro antibacterial activities [PDF]

Journal of Kerman University of Medical Sciences, 1997
Quinolone antibacterial agents are currently used for the treatment of various bacterial infections. The nature of functional group at the 7 position of the quinolone ring system is known to have strong influence on the spectrum and extent of in vitro ...
A.R Foromandi, P Haghighat, S Emami, M.H Moshefi   +3 more
doaj  

Use of Quinolones for the Treatment of Osteomyelitis and Septic Arthritis [PDF]

, 2017
The low minimal inhibitory concentrations and minimal bactericidal concentrations of the quinolones for most pathogenic gram-negative and many gram-positive organisms, the ease of their administration, and their good oral absorption make them good ...
Waldvogel, Francis A.
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