Results 101 to 110 of about 44,560 (245)

Quantification of Antibiotic Diffusion in Biofilms Using Gold Nanostar Surface‐enhanced Raman Spectroscopy

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Gold nanostar‐enhanced Raman spectroscopy (SERS) enables real‐time, label‐free tracking of levofloxacin diffusion in intact biofilms. Nanostars embedded 16 µm below the surface detect drug arrival over time, revealing the impact of the biofilm matrix on antibiotic transport. Abstract The increased resistance to antibiotics shown by bacteria in biofilms
Wafaa Aljuhani, Yingrui Zhang, Matthew P. Wylie, Colin P. McCoy, Steven E. J. Bell   +4 more
wiley   +1 more source

Porin‐Independent Uptake of Small Molecule Antibiotics Facilitated by Escherichia coli Outer Membrane Vesicles

Biotechnology and Bioengineering, Volume 123, Issue 1, Page 235-244, January 2026.
We demonstrate that bacterial outer membrane vesicles (OMVs) can enhance antibiotic delivery into Gram‐negative bacteria by bypassing porin‐dependent uptake. Encapsulation of imipenem in OMVs significantly increased its effectiveness against multidrug‐resistant clinical isolates, highlighting OMVs as a promising platform for overcoming permeability ...
Meishan Wu, Rachael M. Harrower, Ziang Li, Angela C. Brown   +3 more
wiley   +1 more source

Structure of PqsD, a Pseudomonas Quinolone Signal Biosynthetic Enzyme, in Complex with Anthranilate

, 2009
Asim K. Bera, V. Atanasova, Howard Robinson, Edward Eisenstein, James P. Coleman, Everett C. Pesci, James F. Parsons   +6 more
openalex   +1 more source

Unprecedented Nitrite‐Dependent Aromatic Amination to Synthesize 2,4‐Diamino‐3‐Hydroxybenzoic Acid

ChemBioChem, Volume 27, Issue 2, January 2026.
By comparing the biosynthetic gene clusters for natural products with 2,4‐diamino‐3‐hydroxybenzoic acid (2,4,3‐DAHBA) moiety and heterologous expression in Streptomyces albus, we identified nine genes required for the biosynthesis of 2,4,3‐DAHBA, including nitrite biosynthesis genes.
Ko Kuwabara, Yohei Katsuyama, Yasuo Ohnishi   +2 more
wiley   +1 more source

Sequential Carboborylation–Suzuki Coupling of α,β‐Unsaturated Tosylhydrazones: A Dual CC Bond‐Forming Strategy for Molecular Diversification

ChemistryEurope, Volume 4, Issue 1, January 2026.
Structural diversity can be generated from α,β‐unsaturated carbonyls via N‐tosylhydrazones through a one‐pot‐three‐component photochemically promoted carboborylation/allylic Suzuki sequence. The wide availability and scope regarding each of three reaction partners: carbonyls, alkylboronic acids, and aryl halides, and the functionalities available in ...
Álvaro Valdés‐Maqueda, Manuel Plaza, Carlos Valdés   +2 more
wiley   +1 more source

Drug interactions of quinolone medicine and nonsteroidal medicine in GABA receptor binding. Structure-activity relationship from the viewpoint of nonsteroidal medicine.

, 1997
Seiji Hori
openalex   +2 more sources

Development of New Benzo[b]Thiophene‐2‐Carboxamide Derivatives as Advanced Glycation End‐Products Receptor (RAGE) Antagonists

ChemMedChem, Volume 21, Issue 1, January 2026.
A streamlined Ullmann‐Goldberg strategy enabled the synthesis of benzo[b]thiophene‐2‐carboxamides, promising ligands of the pro‐inflammatory RAGE receptor involved in inflammaging and age‐related diseases. LC‐MS, NMR, X‐ray and DFT studies elucidated the copper‐catalyzed mechanism. The lead compound, 3t’, shows inhibitory activity on the sRAGE/AGE2‐BSA
Lisa Bonin, Matthieu Hedouin, Christophe Furman, Ophélie Not, Steve Lancel, Mona Bensalah, Gael Coadou, Eric Boulanger, Sergiu Shova, Hassan Oulyadi, Alina Ghinet   +10 more
wiley   +1 more source

Electrochemical Behavior of 1-Methyl-2-oxo-4,5-dichloro-quinolone in Aprotic Media at Glassy Carbon Electrode [PDF]

, 2015
Anubha Ramswaroop, Kapil Sharma, Deependra Jhankal, Sharma, Y L Chen, K C Fang, J Y Sheu, S Hsu, C C Tzeng, G Roma, M Braccio, G Grossi, M Chia, O Billker, V Lindo, M Panico, A Etiene, T Paxton, A Dell, M Rogers, R Sinden, H R Morris, V Kouznetsov, L Mendez, C M Gomez, A Combes, R H F Manske, M P Shraddha, D Kinjal, H Rajesh, N Shyamali, H D Pate, K Mamta, D K Sharma, K Mamta, D K Sharma, K Sharma, D Sharma, C M Gupta, K Sharma, S Sharma, G Mourya, M Kumari, K Shekhawat, H Sharma, S Bhargav, D K Sharma, P Zuman, B Barns, A Rovolova, H Schultz, F D Popp, R Nicholson, R Kolvada, M Kopanica   +54 more
openalex   +1 more source

Exploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter

ChemMedChem, Volume 21, Issue 1, January 2026.
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri, Madeline G. Dans, Zijun Low, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Deyun Qiu, Adele M. Lehane, Benigno Crespo, Franciso‐Javier Gamo, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +14 more
wiley   +1 more source

Adherence to Surgical Antimicrobial Prophylaxis Guidelines and Improvement Efforts: A Single‐Center, Pre‐ and Post‐Intervention Comparison Study

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims Adherence to surgical antimicrobial prophylaxis (SAP) guidelines reduces the incidence of surgical site infections (SSIs) and improves prognosis and healthcare economics. This single‐center, pre‐ and post‐intervention comparative study investigated SAP guidelines adherence. Accordingly, we intervened where improvements were
Chie Yamamoto, Yoko Nukui, Tadashi Kosaka, Kazuhiro Aoto, Rina Kozen, Kayo Hasegawa, Chikae Ota, Yuki Inoue, Masashi Taniguchi, Ryosuke Hamashima, Keitaro Furukawa, Keisuke Kikuchi, Ayami Nakanishi, Satoshi Teramukai, Yasuhiko Horii, Teiji Sawa   +15 more
wiley   +1 more source