Results 61 to 70 of about 101,168 (296)

Hypersensitivity reactions to quinolones

Current Opinion in Allergy & Clinical Immunology, 2011
The purpose of this review is to examine in detail the new advances in the pathomechanisms and diagnosis of immediate and nonimmediate hypersensitivity reactions to quinolones, as well as analyze cross-reactivity among different quinolones.Hypersensitivity reactions to quinolones, especially anaphylactic reactions, have become more common in the past ...
Inmaculada Andreu, Natalia Blanca-López, Maria Jose Torres Jaén   +2 more
openaire   +4 more sources

Substrate Epoxidation Catalyzed by the Nonheme Iron Dioxygenase Dapdiamide Biosynthesis Enzyme C. Why Is the Substrate Tethered?

Chemistry – A European Journal, EarlyView.
In this work a computational study shows the differences in binding and catalysis of a nonheme iron oxygenase with tethered versus nontethered substrate. The tethered substrate is positioned in an ideal orientation near the active site, while the nontethered substrate shows more dynamics and is not positioned well for double bond epoxidation.
Jingyu Cao, Sam P. de Visser
wiley   +1 more source

Restrictive antibiotic stewardship associated with reduced hospital mortality in gram-negative infection [PDF]

, 2017
Introduction: Antimicrobial stewardship has an important role in the control of Clostridium difficile infection (CDI) and antibiotic resistance. An important component of UK stewardship interventions is the restriction of broad-spectrum beta-lactam ...
Helps, Alieen, Irvine, Sharon C., Jones, Brian L., Ritchie, Neil D., Robb, Fiona, Seaton, R. Andrew   +5 more
core   +1 more source

Transition Metal Carbide‐Based Catalysis for Thermocatalytic Conversion Processes: Properties, Synthesis, Applications, and Future Outlook

ChemNanoMat, EarlyView.
Transition metal carbides (TMCs) have electronic structure similar to that of platinum group metals, making them attractive for thermocatalysis applications. This review explores several essential aspects, discussing physical and chemical properties of TMCs, synthesis methods, and their utilization in thermocatalytic processes, including generation of ...
Edris Madadian, Yasaman Ghaffari, Yael Zilberman, David S. A. Simakov   +3 more
wiley   +1 more source

Wild birds as carriers of antimicrobial-resistant and ESBL-producing Enterobacteriaceae [PDF]

, 2016
open6noopenDotto, G.; Menandro, M.L.; Mondin, A.; Martini, M.; Tonellato, F.R.; Pasotto, D.Dotto, Giorgia; Menandro, MARIA LUISA; Mondin, Alessandra; Martini, Marco; Tonellato, F.
Dotto, Giorgia, Martini, Marco, Menandro, Maria Luisa, Mondin, Alessandra, Pasotto, Daniela, Tonellato, F. R.   +5 more
core   +1 more source

Legionella: macrolides or quinolones? [PDF]

Clinical Microbiology and Infection, 2006
Following the first outbreaks of legionnaire's disease, erythromycin emerged as the treatment of choice without the foundation of rigorous clinical trials. The number of therapeutic failures with erythromycin, as well as the side-effects and drug interactions, led to the consideration of other drugs such as the new macrolides and quinolones for the ...
L. Pedro-Botet, Victor L. Yu
openaire   +3 more sources

Risk of Infections with SGLT2 Inhibitors Versus DPP4 Inhibitors: A Population‐Based Cohort Study Using Antibiotic Dispensing Data

Clinical Pharmacology &Therapeutics, EarlyView.
This study compared the number and cumulative dose of antibiotic dispensings among new users of sodium–glucose cotransporter‐2 (SGLT2) inhibitors and dipeptidyl peptidase‐4 (DPP4) inhibitors following hospital discharge in individuals with type 2 diabetes.
Maria J. Alfonso Arvez, George S. Q. Tan, Sam Wade, Zanfina Ademi, Jenni Ilomäki, J. Simon Bell   +5 more
wiley   +1 more source

Role of the Water–Metal Ion Bridge in Mediating Interactions between Quinolones and Escherichia coli Topoisomerase IV

Biochemistry, 2014
Although quinolones have been in clinical use for decades, the mechanism underlying drug activity and resistance has remained elusive. However, recent studies indicate that clinically relevant quinolones interact with Bacillus anthracis (Gram-positive ...
Katie J. Aldred, Erin J. Breland, Vladislava Vlčková, M. Strub, K. Neuman, R. Kerns, N. Osheroff   +6 more
semanticscholar   +1 more source

Insights into the Base‐Stabilized Silylene Nature of the IrSi Bond in Ir(III)–(κ2‐NSi) Complexes with 2‐Quinolone and 2‐Pyridone Type Ligands

European Journal of Inorganic Chemistry, EarlyView.
Density functional theory calculations (natural bond orbital and quantum theory of atoms in molecules analyses) on Ir–(κ2‐NSi) complexes with 2‐quinolone and 2‐pyridone derived ligands indicate that the bond is best described as a base‐stabilized silylene. The silicon environment is the key for determining the nature of the IrSi bond.
Marina Padilla, María Batuecas, Pilar García‐Orduña, Luis A. Oro, Francisco José Fernández‐Alvarez   +4 more
wiley   +1 more source

Use of Quinolones for the Treatment of Osteomyelitis and Septic Arthritis [PDF]

, 2017
The low minimal inhibitory concentrations and minimal bactericidal concentrations of the quinolones for most pathogenic gram-negative and many gram-positive organisms, the ease of their administration, and their good oral absorption make them good ...
Waldvogel, Francis A.
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