Results 61 to 70 of about 60,375 (278)

Optimization Strategies Aimed to Increase the Efficacy of Helicobacter pylori Eradication Therapies with Quinolones

Molecules, 2020
H. pylori infection is the main cause of gastritis, gastroduodenal ulcer disease, and gastric cancer. Fluoroquinolones such as levofloxacin, or more recently moxifloxacin or sitafloxacin, are efficacious alternatives to standard antibiotics for H. pylori
Javier P. Gisbert
doaj   +1 more source

A Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8, Bound to DNA Gyrase [PDF]

, 2009
Simocyclinones are bifunctional antibiotics that inhibit bacterial DNA gyrase by preventing DNA binding to the enzyme. We report the crystal structure of the complex formed between the N-terminal domain of the Escherichia coli gyrase A subunit and ...
A. Maxwell, A. R. McKay, C. E.M. Stevenson, D. M. Lawson, Flatman, Flatman, Galm, H.-P. Fiedler, L. A. Mitchenall, Laponogov, Lewis, Li, Livermore, M. J. Buttner, M. J. Edwards, Maxwell, Maxwell, Morais Cabral, Oliphant, R. H. Flatman, Ruiz, Schimana, Schoeffler, T. A. Clarke, T. B.K. Le, Theobald, Trefzer, Tsai, Yoshida, Yoshida   +29 more
core   +1 more source

Cp*Co(III)‐catalyzed C–H functionalization of bioactive heterocyclic motifs

Bulletin of the Korean Chemical Society, EarlyView.
Directed carbon–hydrogen bond functionalization of biologically active scaffolds is attractive as it enables the selective modification of sophisticated structures, enhancing the efficiency of drug development by adopting diverse functional groups. This review summarizes recent advances in cobalt‐catalyzed C–H functionalizations of bioactive motifs ...
Yeongmi Park, Junbeom Park, Yong Ho Lee, Jongwoo Son   +3 more
wiley   +1 more source

Topical Antibiotic Therapy in the Ocular Environment: The Benefits of Using Moxifloxacin Eyedrops

Microorganisms
Moxifloxacin is a fourth-generation fluoroquinolone antibiotic available for ophthalmic use. It inhibits two enzymes involved in bacterial DNA synthesis, covering Gram-positive and Gram-negative pathogens. This spectrum allows for the formulation of self-
Lorenzo Drago
doaj   +1 more source

DIVERSITY OF ANTIMICROBIAL RESISTANCE MECHANISMS IN SALMONELLA

Инфекция и иммунитет, 2014
. Current review presents information on the antimicrobial resistance of Salmonella of various serotypes. The phenotypes of resistance and the main resistance mechanisms to the antimicrobials of various groups are described.
L. A. Kaftyreva, S. A. Egorova, M. A. Makarova, A. V. Zabrovskaya, Z. N. Matveeva, L. V. Suzhaeva, E. V. Voitenkova   +6 more
doaj   +1 more source

Sustainable Water Decontamination: Advanced High‐Valent Iron Active Species‐Driven Peroxymonosulfate Activation for Global Challenges

CleanMat, EarlyView.
Iron‐based catalysts activate peroxymonosulfate (PMS) to generate high‐valent iron‐oxo species for water decontamination and clean water production. The activation efficiency of PMS varies significantly depending on iron catalyst properties, while the generation of reactive high‐valent iron intermediates is governed by catalyst characteristics ...
Junpeng Guo, Miao Lei, Ling Yan, Junhang Huang, Chang Liu, Li Ye, BoLin Li, Xingtao Xu, Ye Li   +8 more
wiley   +1 more source

Photocatalytic Degradation of Quinolones by Magnetic MOFs Materials and Mechanism Study

Molecules
With the rising incidence of various diseases in China and the constant development of the pharmaceutical industry, there is a growing demand for floxacin-type antibiotics.
Hongchao Chang, Guangyao Xu, Xiantong Huang, Wei Xu, Fujuan Luo, Jiarong Zang, Xiaowei Lin, Rong Huang, Hua Yu, Binbin Yu   +9 more
doaj   +1 more source

Identification, Genotyping and Antimicrobial Susceptibility Testing of Brucella spp. Isolated from Livestock in Egypt [PDF]

, 2019
Brucellosis is a highly contagious zoonosis worldwide with economic and public health impacts. The aim of the present study was to identify Brucella (B.) spp. isolated from animal populations located in different districts of Egypt and to determine their
El-Adawy, Hosny, Elschner, Mandy C., Khan, Aman Ullah, Melzer, Falk, Moawad, Amira A., Neubauer, Heinrich, Ramadan, Eman Shawkat, Roesler, Uwe, Sayour, Ashraf E., Shell, Waleed S.   +9 more
core   +1 more source

Pharmacokinetics and Safety Evaluation of a New Generic Sitafloxacin: A Phase I Bioequivalence Study in Healthy Chinese Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Sitafloxacin is a new antibiotic drug belonging to the fourth generation quinolone antibiotics. The aim of this study was to evaluate the pharmacokinetics (PK), safety profiles, and bioequivalence of test and reference 50‐mg sitafloxacin tablets under fasting and fed conditions.
Yongfang Lei, Pan Luo, Yuzhu Chen, Liuliang Xue, Donglin Zhang, Xingxing Qi, Yinian Fang, Hengyi Yu, Zheng He, Qin Zuo, Chang Liu, Dong Liu, Xinhua Ren, Qian Chen   +13 more
wiley   +1 more source

Safety analysis of quinolones use in minors—based on the FAERS database

Frontiers in Medicine
ObjectiveThis study utilizes the FDA Adverse Event Reporting System (FAERS) to investigate adverse drug event (ADE) signals linked to quinolones use (ciprofloxacin, moxifloxacin, levofloxacin, ofloxacin) in minors, offering insights for clinical use ...
Yanwei Li, Jing Wang, ChengLiang Wang, Li Chen, Li Chen, Li Chen   +5 more
doaj   +1 more source